581 research outputs found

    Corrigendum to ‘Eribulin in combination with bevacizumab as second-line treatment for HER2-negative metastatic breast cancer progressing after first-line therapy with paclitaxel and bevacizumab: a multicenter, phase II, single arm trial (GIM11-BERGI)’: (ESMO Open (2021) 6(2), (S2059702921000089), (10.1016/j.esmoop.2021.100054))

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    The authors regret that at the time the article was published the following two authors were missing from the author list: R. Caputo and D. Cianniello. Both authors affiliation is the Breast Oncology Department, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy. The updated author list is as follows: C. De Angelis, D. Bruzzese, A. Bernardo, E. Baldini, L. Leo, A. Fabi, T. Gamucci, P. De Placido, F. Poggio, S. Russo, V. Forestieri, R. Lauria, I. De Santo, R. Caputo, D. Cianniello, A. Michelotti, L. Del Mastro, M. De Laurentiis, M. Giuliano, S. De Placido, G. Arpino. The authors would like to apologise for any inconvenience caused

    The Effect of Tillage on Faba Bean (Vicia faba L.) Nitrogen Fixation in Durum Wheat ((Triticum turgidum L. subsp. Durum (Desf))-Based Rotation under a Mediterranean Climate

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    Biological nitrogen fixation (BNF) is a sustainable approach to improving soil fertility that not only provides nitrogen to subsequent crops but also reduces the impacts of synthetic fertilizers. Here, a field experiment was established within the faba bean (Vicia faba L.), cv Prothabat 69-durum wheat (Triticum turgidum L. subsp. Durum (Desf)), cv Iride rotation framework of a long-term experiment in southern Italy to quantify BNF over two consecutive years (2012/13–2013/14). The effect of tillage systems (reduced, conventional, and no tillage) on faba bean N2 fixation was estimated at the flowering and maturity stages via the natural abundance technique, using wheat as a reference crop. The effect of tillage on the percentage of nitrogen fixation from the atmosphere (Ndfa) and the amount of N2 fixed (kg ha−1) were higher under a no-tillage system in both years and at both growth stages, with values of 66.5% at flowering and 81.7% at maturity. The same trend was reported for the amount of N2 fixed (kg N ha−1) at both faba bean growth stages. The N balance was positive in both years, with a mean value of 40.4 kg N ha−1, across all tillage systems; this value was greater in the no-tillage systems (45.7 kg N ha−1) with respect to the others. The values for the organic matter content and stability index were higher under the no-tillage system, which provided favourable conditions that improved N2 fixation by faba beans. The overall results indicate that no-tillage soil management represents a sustainable strategy for improving soil quality and fertility, therefore reducing the dependency of agriculture on synthetic fertilizers

    Implications of no-tillage system in faba bean production: Energy analysis and potential agronomic benefits

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    Background: Given the nutritional value of faba bean, however its susceptibility to water deficit, especially in Mediterranean environment, tillage practices need to be modified in order to adapt the crop to dry and low rainfall conditions and promote the interest in its cultivation. Objective: To identify whether no-tillage system can be considered as a sustainable means in faba bean cultivation under Mediterranean condition. Method: The study was conducted during a 6-year period (2010/11 to 2015/16) in southern Italy within wheat-faba bean rotation framework of a long-term experiment. The effect of No-Tillage (NT) on agronomic and energy parameters of faba bean (Vicia faba L.) cultivation was evaluated and compared to those of Conventional (CT) and Reduced (RT) Tillage. Results: The agronomic results indicate that NT performed better and/or is comparable to CT, while its application was 28% and 30% more energy efficient compared to CT and RT respectively. For agronomic parameters, tillage had a significant effect on number of plant m -2 , grain yield, grain protein content and 100-seed weight whereas year effect was significant for yield components and quality parameters. Energy indexes, instead, were significantly affected by both factors. NT gave the best results in terms of energy efficiency, energy intensity and net energy, and consumed 39% and 36% less non-renewable energy than CT and RT, respectively. Conclusion: Our findings revealed that the key benefit of NT in rainfed faba bean is its ability to produce sufficient yield of high quality with a significant reduction in energy inputs entailed the fewest field operations and therefore lowest energy requirements

    Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases

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    Tamoxifen is frequently used as adjuvant treatment in premenopausal patients with hormone receptor-positive early breast cancer. According to guidelines, the use of nonhormonal barrier contraception is recommended during tamoxifen treatment and up to 3 months after its interruption prior to attempting conception. Nevertheless, when conception occurs inadvertently during tamoxifen treatment, the effects on the fetus and on the course of pregnancy are still not completely known. Here, we report 3 cases of young women who accidentally became pregnant while taking tamoxifen and perform a systematic review of the literature to provide more elements for better and clear multidisciplinary counselling of women facing this challenging situation
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