18,934 research outputs found
Getting Published A Guide for Lecturers and Researchers
No full textThis handy guide for new and practising lecturers and researchers takes a rare insider's look at the activities of writing and publishing. Turning the spotlight inwards, it examines how and why professionals communicate with each other through writing and publishing. Written with great verve and pace, the author succeeds in providing sensible advice bolstered by many illustrative examples, case studies and anecdotes. For the academic needing insight into the serious business of getting published, this book will provide answers to many of their frequent questions: * Why do they write and publish? * Who are they writing for? * What channels of communication are available for their writing? * Who 'controls' these channels? * How can they successfully submit articles and papers to journals and newspapers, contribute chapters to books, or approach publishers with book proposals? Developed from a series of seminars on the subject by the author, this book will be an enjoyable and informative guide to anyone with an interest in getting their work published.Book Cover -- Half-Title -- Title -- Copyright -- Contents -- Preface -- 1 Why publish? -- 2 What might you publish about? -- 3 Writing and the writing process -- 4 Publishing in journals -- 5 Book publishing -- 6 Practical guidance on writing -- 7 Future publishing -- Appendix 1 -- Appendix 2 -- References -- IndexThis handy guide for new and practising lecturers and researchers takes a rare insider's look at the activities of writing and publishing. Turning the spotlight inwards, it examines how and why professionals communicate with each other through writing and publishing. Written with great verve and pace, the author succeeds in providing sensible advice bolstered by many illustrative examples, case studies and anecdotes. For the academic needing insight into the serious business of getting published, this book will provide answers to many of their frequent questions: * Why do they write and publish? * Who are they writing for? * What channels of communication are available for their writing? * Who 'controls' these channels? * How can they successfully submit articles and papers to journals and newspapers, contribute chapters to books, or approach publishers with book proposals? Developed from a series of seminars on the subject by the author, this book will be an enjoyable and informative guide to anyone with an interest in getting their work published.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Anti-inflammatory and antiosteo-clastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
No full textThe development of biological therapies has improved management of rheumatoid arthritis. However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit their use, making it imperative to identify new targets for drug development programs. Here we investigated the melanocortin-receptor type 3 (MC3) pathway. Gene-deficient mice were subjected to a model of serum-transfer-induced arthritis and joints analyzed for gene expression (cytokines, MCs) and morphology. Pharmacological analyses were also conducted in this model. Osteoclastogenesis was studied from bone marrow cells. Mc3−/− mice displayed an exacerbated inflammatory arthritis, associated with prominent bone erosion and higher articular expression of Rankl. Osteoclastogenesis studied from Mc3−/− bone marrow cells revealed a higher degree of responsiveness to Rankl, linked to prolonged NF-κB activation compared to wild types. Up-regulation of a discrete set of inflammatory genes, including Il-1β, Il-6, and Nos2, was measured in Mc3−/− mice, and a marked up-regulation of joint Mc3 accompanied arthritis resolution in wild-type mice. Administration of an MC3 agonist, D[Trp8]-γ-MSH, attenuated disease incidence and severity in wild-type but not Mc3−/− mice. Overall, these findings identify MC3-mediated signaling as a beneficial pathway in experimental arthritis; hence this receptor is a novel target for the development of therapeutics for arthritis.—Patel, H. B., Bombardieri, M., Sampaio, A. L. F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S. J., Pitzalis, C., Perretti, M. Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
Melanocortin type 3 receptor null mice are refractory to the inhibitory actions of a selective receptor agonist in experimental acute inflammation
No full textAntiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via Annexin-A1 mobilization
No full textObjective—To determine whether a mechanism exists that could operate on application of cromones, antiallertic "mast cell–stabilizing" drugs that release the anti-inflammatory protein annexin-A1 (Anx-A1) from U937 cells and inhibit polymorphonuclear leukocyte (PMN) trafficking, because PMNs can synthesize and release large amounts of Anx-A1.
Methods and Results—Intravital microscopy was used to monitor the actions of cromones in the inflamed microcirculation. Reperfusion injury provoked a dramatic increase in adherent and emigrated leukocytes in the mesenteric vascular bed, associated with augmented tissue levels of myeloperoxidase. Nedocromil, 2 to 20 mg/kg, significantly (P<0.05) inhibited cell adhesion and emigration, as well as myeloperoxidase release, in wild-type but not Anx-A1-/- mice. Short pretreatment of human PMNs with nedocromil, 10 nmol/L, inhibited cell adhesion (P<0.05) in the flow chamber assay, and this effect was reversed by specific anti-AnxA1 or a combination of anti–formyl peptide receptors 1 and 2, but not irrelevant control, antibodies. Western blotting experiments revealed that cromones stimulate protein kinase C–dependent phosphorylation and release Anx-A1 in human PMNs.
Conclusion—We propose a novel mechanism to explain the anti-inflammatory actions of cromones on PMN trafficking, an effect that has long puzzled investigators
[D-Trp8]-{gamma}-MSH exhibits anti-inflammatory efficacy in mice bearing a non-functional MC1R (recessive yellow e/e mouse).
No full textHome ownership: Getting in, getting from, getting out. Part III
No full textThis book provides an overview of the effects of home ownership, a housing sector that has grown rapidly in recent years in many countries, not least because this is normally encouraged by governments. The first part of the subtitle, ‘Getting in’, refers to processes in the development of the homeownership stock including problems of access, which in turn implies issues of affordability, the viability of financial institutions and subsidies. ‘Getting from’ indicates that this form of housing tenure may provide households with advantages such as wealth accumulation and independence that may not be available to tenants. Finally, the last section ‘getting out’ refers to the risks associated with home ownership such as the fact that their tenure positions may be founded on their ability to meet loan repayments. This publication is a follow-up to Home ownership: Getting in, getting form and getting out, parts I and II, and is a result of the conference ‘Building on home ownership; housing policies and social strategies’ in Delft, organized by the ENHR working group Home ownership & Globalisation and hosted by OTB Research Institute for Housing, Urban and Mobility Studies, Delft University of Technology. Part III provides an overview of the most recent research results in this field.OTBArchitecture and The Built Environmen
John J. Buchanan to C. S. Buchanan, January 13, 1862
No full textIn this letter of January 13, 1862, John J. Buchanan writes to his brother C. S. Buchanan from Beaufort District, South Carolina. John Buchanan acknowledges that he received C. S. Buchanan's letter with heartbreaking news and feels mournful. He has the measles, but is getting better, and he urges the boys of Jackson County to not join W. H. Thomas’s new company
Reply to “Asking the Right Question Is Key to Getting a Valuable Answer” (Letter)
No full textAuthor response to the JOSPT Letter to the Editor-in-Chief "Asking the Right Question is Key to Getting a Valuable Answer" J Orthop Sports Phys Ther 2023;53(11):726-727. doi:10.2519/jospt.2023.0204-R.No Full Tex
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor null mice after ischaemia-reperfusion
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