1,370 research outputs found
Rawlings, Gerard Cecil Inui, Singapore
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/412425Surname: RAWLINGS. Given Name(s) or Initials: GERARD CECIL INUI. Military Service Number or Last Known Location: SINGAPORE. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 20288.229135
Item: [2016.0049.44687] "Rawlings, Gerard Cecil Inui, Singapore
Scattering and blow-up for threshold even solutions to the nonlinear Schrödinger equation with repulsive delta potential at low frequencies
No full textGustafson S., Inui T. Scattering and blow-up for threshold even solutions to the nonlinear Schrödinger equation with repulsive delta potential at low frequencies. Journal of Differential Equations 412, 758 (2024); https://doi.org/10.1016/j.jde.2024.08.072.We consider the L²-supercritical nonlinear Schrödinger equation with a repulsive Dirac delta potential in one dimensional space. In a previous work, we clarified the global dynamics of even solutions with the same action as the high-frequency ground state standing wave solutions. In that case, there are obvious non-scattering global solutions, i.e., the standing waves. In this paper, we show a scattering and blow-up dichotomy for threshold even solutions in the low-frequency case. We emphasize that this dichotomy still holds at the critical frequency between high and low
Inui A. Appetite and gastrointestinal motility: role of ghrelin-family peptides. Clin Nutr 2010
No full texts u m m a r y Eating disorders, obesity and cachexia endanger the lives of millions of people worldwide. Fortunately, in last decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. In 1999, ghrelin was identified as the first orexigenic gut-derived peptide. It stimulates appetite and controls the gastric motility and the acid secretion through the activation of the growth hormone secretagogue-receptor. After the discovery of ghrelin, other forms of ghrelin-related proteins were isolated from the rat stomach. The unmodified des-noctanoyl form (des-acyl ghrelin) and the recent obestatin act through distinct receptors and contrarily to acyl ghrelin, show an anorexigenic activity. The finding that these three peptide hormones derive from the same precursor exert opposing physiological actions, highlights the importance of post-translational regulatory mechanisms. Further investigations are required to highlight the complexity of ghrelin physiology in order to better understand the mechanisms regulating the energy balance and provide a successful treatment of eating disorders, obesity and cachexia
Scattering and blow-up for threshold even solutions to the nonlinear Schrödinger equation with repulsive delta potential at low frequencies
No full textGustafson S., Inui T. Scattering and blow-up for threshold even solutions to the nonlinear Schrödinger equation with repulsive delta potential at low frequencies. Journal of Differential Equations 412, 758 (2024); https://doi.org/10.1016/j.jde.2024.08.072.We consider the L²-supercritical nonlinear Schrödinger equation with a repulsive Dirac delta potential in one dimensional space. In a previous work, we clarified the global dynamics of even solutions with the same action as the high-frequency ground state standing wave solutions. In that case, there are obvious non-scattering global solutions, i.e., the standing waves. In this paper, we show a scattering and blow-up dichotomy for threshold even solutions in the low-frequency case. We emphasize that this dichotomy still holds at the critical frequency between high and low
Signaling crosstalk between TGFβ and Dishevelled/Par1b
No full textCrosstalk of signaling pathways is critical during metazoan development and adult tissue homeostasis. Even though the transforming growth factor-beta (TGF beta) transduction cascade is rather simple, in vivo responsiveness to TGF beta ligands is tightly regulated at several steps. As such, TGF beta represents a paradigm for how the activity of one signaling system is modulated by others. Here, we report an unsuspected regulatory step involving Dishevelled (Dvl) and Par1b (also known as MARK2). Dvl and Par1b cooperate to enable TGF beta/bone morphogenetic protein (BMP) signaling in Xenopus mesoderm development and TGF beta responsiveness in mammalian cells. Mechanistically, the assembly of the Par1b/Dvl3/Smad4 complex is fostered by Wnt5a. The association of Smad4 to Dvl/Par1 prevents its inhibitory ubiquitination by ectodermin (also known as transcriptional intermediary factor 1 gamma or tripartite motif protein 33). We propose that this crosstalk is relevant to coordinate TGF beta responses with Wnt-noncanonical and polarity pathways. Cell Death and Differentiation (2012) 19, 1689-1697; doi:10.1038/cdd.2012.50; published online 11 May 201
A comprehensive assessment using COPD assessment test scoring and modified Medical Research Council dyspnea scoring is necessary for personalized therapy for COPD patients
No full textShinji Teramoto,1 Toshihide Inui,2 Nobuyuki Hizawa3 1Department of Pulmonary Medicine, Hitachinaka Medical Education and Research Center, University of Tsukuba, Ibaraki, Japan; 2Department of Pulmonary Medicine, Hitachinaka General Hospital, Hitachi Ltd, Ibaraki, Japan; 3Department of Pulmonary Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Ibaraki, JapanIn a recent issue of the International Journal of COPD, Rhee et al1 have demonstrated considerable discrepancies between modified Medical Research Council (mMRC) dyspnea scoring and COPD assessment test (CAT) scoring in patients with COPD. The current data are also supported by the findings described in another article, which indicates that more than 50% of COPD patients show discrepancies between the severity of CAT scores and that of mMRC scores in the real world.2 Read the original pape
Expanding the range of chromatic dispersion monitoring with two-photon absorption in semiconductors
No full textChromatic dispersion monitoring based on two-photon absorption (TPA) in semiconductors is very attractive because it does not need any high speed electronic devices (Inui, 2002). However, at present the dispersion monitoring range is limited to half of the Talbot dispersion which is defined as DTalbot = T2c/lambda2 (Wielandy, 2004), T is the period of the signal pulse sequence. In this work we propose a scheme to expand this monitoring range
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