54 research outputs found
Activating Effect of 3‐Benzylidene Oxindoles on AMPK: From Computer Simulation to High‐Content Screening
No full textAMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing processes, and at the whole body level, particularly, regulating certain aspects of higher nervous activity and behavior. Control of such a 'main switch' compensates dysfunctions and associated diseases. In the present paper, we studied the binding of 3-benzylidene oxindoles to the kinase domain of the AMPK alpha-subunit, which is thought to prevent its interaction with the autoinhibitory domain and thus result in the AMPK activation. For this purpose, we developed the cellular test system based on the AMPKAR plasmid, which implements the FRET effect, synthesized a number of 3-benzylidene oxindole compounds and simulated their binding to various sites of the kinase domain. The most probable binding site for the studied compounds was established by the correlation of calculated and experimental data. The obtained results allow to analyze various classes of AMPK activators using virtual and high-content screening
Proapoptotic modification of substituted isoindolinones as MDM2-p53 inhibitors
No full textA series of novel amino acid ester derivatives of 2,3-substituted isoindolinones was synthesized and evaluated for p53-mediated apoptotic activity. The rationale for augmentation of the target activity of 2,3-substituted isoindolinones was based on the introduction of new fragments in the structure of the inhibitor that would provide additional binding sites in the hydrophobic cavity of MDM2. To select for the anticipated modifications we employed molecular docking. Synthesized molecules were evaluated for their ability to induce apoptosis in two cancer cell lines and their derivatives with different status of p53 (colorectal HCT116 and osteosarcoma U2OS cells) by Annexin V staining. The target activity was estimated using high-content imaging system Operetta. Valine and phenylglycine ester derivatives were identified as potentially active MDM2-p53 inhibitors. (C) 2017 Elsevier Ltd. All rights reserved
Comprehensive assessment of the reliability of the bank with the application of statistical methods
No full textRussian banks are forced to work in conditions of high risks and often find themselves in crisis situations. This is due to inadequate assessment of their own financial situation, attracted and placed funds, the reliability and stability of clients. The indicators used for the characteristic of activity of banks, should assess the reliability and efficiency of work. The article gives the reliability prediction of commercial Bank by using statistical analysis methods. Reliability analysis of a commercial Bank is to calculate various indicators of banks ' financial condition based on data from its financial statements, which allow to receive representation about the basic performance of the Bank using regression, correlation, cluster, factor analysis. Different methods and approaches that have been proposed by Russian authors for the analysis and assessment of reliability of commercial banks, testify to the importance of this problem. The authors in the work of the Bank's reliability is meant the probability that the Bank's operations for some period of time to meet certain criteria, i.e. the probability that the Bank will manifest itself as a reliable. The author used General scientific methods: analysis and synthesis, comparisons, generalizations, system approach. In the process of the actual study material used methods of economic and statistical analysis. As a result the main tendencies, problems of reliability of the banking sector
Comprehensive assessment of the reliability of the bank with the application of statistical methods
Get PDFRussian banks are forced to work in conditions of high risks and often find themselves in crisis situations. This is due to inadequate assessment of their own financial situation, attracted and placed funds, the reliability and stability of clients. The indicators used for the characteristic of activity of banks, should assess the reliability and efficiency of work. The article gives the reliability prediction of commercial Bank by using statistical analysis methods. Reliability analysis of a commercial Bank is to calculate various indicators of banks ' financial condition based on data from its financial statements, which allow to receive representation about the basic performance of the Bank using regression, correlation, cluster, factor analysis. Different methods and approaches that have been proposed by Russian authors for the analysis and assessment of reliability of commercial banks, testify to the importance of this problem. The authors in the work of the Bank's reliability is meant the probability that the Bank's operations for some period of time to meet certain criteria, i.e. the probability that the Bank will manifest itself as a reliable. The author used General scientific methods: analysis and synthesis, comparisons, generalizations, system approach. In the process of the actual study material used methods of economic and statistical analysis. As a result the main tendencies, problems of reliability of the banking sector
Use of steiner problem in solving practical problems of road construction
No full text© by the author(s). Currently, the development of road networks is growing rapidly. There is a need in the accession of new sections to the existing roads. The present work sets the task of finding Steiner points for three points. While carrying out this work, there was learnt the basics of graph theory, the methods of finding shortest networks and defined the Steiner problem. There was also implemented an application in Delphi 2010 determining the Steiner point, the minimum path (section) length, and calculating travel time and approximate cost of construction for the resulting road section
Use of steiner problem in solving practical problems of road construction
Get PDF© by the author(s). Currently, the development of road networks is growing rapidly. There is a need in the accession of new sections to the existing roads. The present work sets the task of finding Steiner points for three points. While carrying out this work, there was learnt the basics of graph theory, the methods of finding shortest networks and defined the Steiner problem. There was also implemented an application in Delphi 2010 determining the Steiner point, the minimum path (section) length, and calculating travel time and approximate cost of construction for the resulting road section
The Temple and the Rite: Social Functions of the Sacred by Davydov I.P.
Get PDFThe book under review was published in 2021 and its title can be translated as The Temple and the Rite: Social Functions of the Sacred. It became a result of fifteen years of work conducted by Doctor of Philosophy Ivan Pavlovich Davydov. Epistemology and methodology of religious science, problems of myth and rite, as well as the issues of religious art, are central to his research. The basic method used by I. P. Davydov is structural functionalism and the theoretical base he applies is the philosophy of Postmodernism represented by the names of G. Bataille, R. Caillois, J. Kristeva, M. Foucault, M. Blanchot. The book is divided into two main parts. In the first part I. P. Davydov focuses on theoretical issues: the concept of transgression in the philosophy of Postmodernism, definition of the term religion, description of the functions of religion, and specification of the myth-ritual concept. The author introduces his original method of functional analysis of archetypal images of the collective unconscious. In the second part of the book, the author deals with the study of Christian hymnography, iconography, and architecture through the prism of the method mentioned above. It can be regarded as an attempt to substantiate and verify the theoretical constructions of the first part by analyzing the empirical material of religious art. This part of the research serves to illustrate the practical application of the author’s method. Here the author defines major religious concepts, such as semiotics of sacred spaces, iconography, iconology, and icon, from the position of religious studies and philosophy and substantiates their scientific importance. We may conclude that this work in light of the latitude of the problems raised in it can be useful for the wide range of researchers working not only in the field of religious studies but also in the other fields of knowledge: anthropology, cultural studies, art history, psychoanalysis, etc. The readers can acquaint themselves with the method of functional analysis in the first part of the book and adapt it to their research, using the examples from the second part of the book as the patterns
Study of hardiness of adolescents with severe speech disorders
No full textПо мере развития идей инклюзивного образования остро встает вопрос изучения и сопровождения детей с ограниченными возможностями здоровья. Особое место здесь занимают дети с менее выраженными и более перспективными в части коррекции имеющихся нарушений, в первую очередь, дети и подростки с тяжелыми нарушениями речи.
В статье описываются психологические особенности жизнестойкости подростков с тяжелыми нарушениями речи (ТНР).
С опорой на исследования Т.Н. Волковской, В.А. Калягина, С.В. Лауткиной, Р.Е. Левиной, Т.С. Овчинниковой, Г.Х. Юсуповой и др., в статье анализируются психологические особенности детей и подростков с ТНР, которые в дальнейшем подтверждаются эмпирическими данными, собранными авторами.
Исследование проводилось с применением модифицированного теста жизнестойкости С. Мадди, опросника «Способы совладающего поведения» Р. Лазаруса и С. Фолкман, личностного опросника Г. Айзенка, методики диагностики самооценки личности Дембо-Рубинштейн.
Для выявления расширенного психологического содержания жизнестойкости подростков с ТНР изучались дополнительные психологические характеристики, такие как уровни самооценки и притязаний, экстраверсии-нейротизма, а также способов совладающего поведения. Анализ данных проводился с применением корреляционного и факторного анализа.
На основе теоретических и эмпирических данных появляется возможность внести в содержание работы с данной категорией детей и подростков направления деятельности, позволяющие научить их преодолевать трудности, правильно относиться к получаемому опыту, накапливать уверенность в своих силах и осваивать адаптивные способы совладающего поведения. На основе материалов исследования могут быть разработаны рекомендации для педагогов и родителей.With the development of the ideas of inclusive education is very important for study and supporting children with disabilities. A special place is occupied by children with less severe and more promising in terms of correcting existing violations, primarily children and adolescents with severe speech disorders. The article describes the psychological characteristics of resilience in adolescents with severe speech disorders (SSD). Based on the research of T. N. The Volkov, V. A. Kalyagin, S. V. Laudino, R. E. Levina, T. S. Ovchinnikova, Gulnara Yusupova, and others, the article analyzes the psychological characteristics of children and adolescents with TNR, which further confirmed the empirical data collected by the authors. The study was conducted with the use of a modified test of resilience S. muddy, questionnaire "Ways of coping" by R. Lazarus and S. Folkman, personal questionnaire G. Eysenck, methods of diagnostics of self-identity Dembo-Rubinstein. For identifying enhanced the content of the psychological resilience of adolescents with SSD studied additional psychological characteristics, such as levels of self-esteem and claims of extroversion-neuroticism, as well as ways of coping behavior. The data were analyzed using correlation and factor analysis. Based on theoretical and empirical data an opportunity to amend the content of the work with this category of children and adolescents the interventions that teach them to overcome difficulties, the right attitude to experience, to gain confidence and learn adaptive ways of coping behavior. Based on the research materials can be developed recommendations for teachers and parents
The study of molecular histograms of interatomic distances in organic homologs on the basis of R/S analysis
No full textСамоопределение коренных малочисленных народов Крайнего Севера: на примере саамов
Get PDFРабота основана на анализе феномена идентичности чрез призму коренного малочисленного народа Крайнего Севера - саами. Политика Крайнего Севера ставит серьезные задачи перед коренными народами, национальными властями и их промышленными интересами на землях и территориях коренных народов. Это может повлечь за собой последствия, которые пагубно сказываются на уровне жизни коренных малочисленных народов. В то же время такая ситуация открывает возможности для повышения благосостояния за счет устойчивого и справедливого управления природными ресурсами.
Живое саамское общество представляет собой плацдарм для развития, а территория, на которой они проживают, - уникальные ресурсы. Поэтому политика Крайнего Севера должна разрабатываться и осуществляться в рамках диалога и сотрудничества между саамскими парламентами, саамскими правообладателями, саамскими заинтересованными организациями, властями и представителями промышленности на территории Российской Федерации, Республики Финляндия, Королевства Швеция и Королевства Норвегия.
Актуальность темы данного исследования определяется следующим:
Во-первых, трудно переоценить вклад XX века в развитие, разработку совершенно иного, нового отношения к коренным малочисленным народам с точки зрения социального статуса. Однако правовое оформление такого статуса все еще не находится на уровне слаженного функционирующего аппарата международного формата.
Во-вторых, на сегодняшний день внутри национальных законодательств описываемых стран достаточно остро стоит вопрос о соответствии формируемого законодательства для коренных малочисленных народов Крайнего севера вызовам и угрозам современных рыночных отношений, от которых зависит вопрос традиционного землепользования коренных народов.
В-третьих, Арктический регион на сегодняшний день становится приоритетным объектом изучения с точки зрения новой международной арены взаимодействия. Растущее количество игроков международной арены Арктического региона все чаще претендует на возможность владения и использования природных ресурсов северных территорий, являющихся традиционными территориями проживания коренных малочисленных народов.
В-четвертых, проблематика права на самоопределение коренных малочисленных народов представленная как право пользования, владения и эксплуатации земельных и природных ресурсов с целью реализации самобытного вида хозяйствования зачастую не находит реального отражения в современных условиях жизни в описываемых странах.
Целью данной работы является выявление характерных особенностей выстраиваемой национальной идентичности транснационального коренного малочисленного народа Крайнего Севера – саами.
Для достижения цели перед автором были поставлены следующие исследовательские задачи:
Во-первых, проанализировать социально-правовое реальное положение представленности саами на территории Королевства Норвегия, Королевства Швеция, Республики Финляндия, Российской Федерации;
Во-вторых, исследовать национальное законодательство по отношению саами в вышеупомянутых странах;
В-третьих, изучить феномен национальной идентичности посредством сопоставления современных теорий международных отношений;
В-четвертых, выявить уровень международной представленности саами в рамках реализации конструирования транснациональной идентичности коренного народа;
В-пятых, определить характер процесса выстраивания идентичности посредством смешанного количественного и качественного контент-анализов уставных документов неправительственных общественных организаций саами.
Объектом исследования является национальная политика Российской Федерации, Королевства Норвегия, Королевства Швеция, Республики Финляндия по отношению к коренному малочисленному народу Крайнего Севера – саами.
Предметом исследования является особенность формирования аспектов транснационального инструмента внешней политики – национальной идентичности коренного малочисленного народа саами.
Научная новизна данного исследования определяется такими факторами, как:
Во-первых, автор работы комплексно изучил национальное законодательство четырех арктических государств по отношению к коренному народу;
Во-вторых, автор работы посредством данного исследования предлагает использование процесса идентичности в качестве ведущего инструмента внешней политики в Арктическом регионе;
В-третьих, впервые в научный оборот вводятся документы на диалектах саамского языка. Также в работе использованы источники на норвежском, финском и шведском языках.
Методологическую основу исследования составили общенаучные и специальные методы. Автор исследования использовал количественный контент-анализ и качественный контент-анализ для достижения поставленных задач.
Также, из общенаучных методов в данном труде используются такие методы, как: анализ, обобщение, индукция, наблюдение.
Автор использовал сравнительно-правовой метод для сопоставления нормативно-правовых баз современного законодательства Российской Федерации, Королевства Норвегия, Королевства Швеция, Республики Финляндия по отношению к коренному малочисленному народу Крайнего Севера саами.
Характеристика источниковой базы.
Первую группу источников составляют официальные законодательные акты, регулирующие и обеспечивающие реализацию прав коренного малочисленного народа саами на территории Российской Федерации , Королевства Норвегия , Республики Финляндия , Королевства Швеция .
Вторая группа представлена официальными международными актами , регулирующими представительство коренного малочисленного народа.
Третья группа источников объединяет основные официальные уставы и документы , принятые и провозглашённые неправительственными организациями саами.
Четвертая группа источников представлена статьями научных периодических изданий, электронными журналами, описывающими современное положение народа Крайнего Севера.
Пятая группа источников содержит монографии, посвященные теоретическому обоснованию феномена идентичности и шестая группа источников представлена интернет-ресурсами освещаемой темы.
Степень изученности темы.
На сегодняшний день тема самоопределения коренного малочисленного народа Крайнего Севера саами определяется использованной автором данной работы литературы, статьей отечественных и зарубежных исследователей, которые освещали тему самоопределения коренного малочисленного народа в ретроспективе.
Наибольшую ценность для исследования самоопределения коренного малочисленного народа Крайнего Севера Саами предоставили работы таких исследователей, как Акуца Ф. Р., Вукопов Н. В, Денисова В.В, Сильникова А.А, Харлампьева Н. К, а также работы зарубежных авторов, как Wendt A., Anaya J., Lasswel H., Mitrany D. и т.д.The thesis is based on the analysis of the phenomenon of identity through the prism of the indigenous people of the Far North - the Sami. The policy of the Far North sets serious tasks for indigenous peoples, national authorities and their industrial interests in the lands and territories of indigenous peoples. This may entail consequences that adversely affect the standard of living of small indigenous peoples. At the same time, this situation opens up opportunities for improving well-being through sustainable and equitable management of natural resources.
Living Sami society is a springboard for development, and the territory in which they live is unique resources. Therefore, the policy of the Far North should be developed and implemented within the framework of dialogue and cooperation between Sami parliaments, Sami rightholders, Sami interested organizations, authorities and industry in the Russian Federation, the Republic of Finland, the Kingdom of Sweden and the Kingdom of Norway.
The relevance of the topic of this study is determined by the following:
First, it is difficult to overestimate the contribution of the twentieth century to development, the development of a completely different, new attitude towards small indigenous peoples in terms of social status. However, the legal registration of such a status is still not at the level of a well-coordinated functioning apparatus of international format.
Secondly, today, within the national legislations of the countries described, the issue of the conformity of the forming legislation for indigenous peoples of the Far North to the challenges and threats of modern market relations, on which the issue of traditional land use of indigenous peoples depends, is quite acute.
Thirdly, the Arctic region today is becoming a priority object of study from the point of view of a new international arena of interaction. A growing number of players in the international arena of the Arctic region are increasingly claiming the possibility of owning and using the natural resources of the northern territories, which are traditional territories of indigenous peoples.
Fourthly, the problems of the right to self-determination of indigenous small peoples represented as the right to use, own and exploit land and natural resources in order to realize a distinctive type of economy often do not find a real reflection in modern living conditions in the countries described.
The purpose of this work is to identify the characteristic features of the national identity of the transnational indigenous minority people of the Far North - the Sámi who are being built.
To achieve the goal, the author was assigned the following research tasks:
First, analyze the social and legal reality of the Saami representation in the territory of the Kingdom of Norway, the Kingdom of Sweden, the Republic of Finland, the Russian Federation;
Secondly, investigate the national legislation regarding the Sámi in the aforementioned countries;
Thirdly, to study the phenomenon of national identity by comparing modern theories of international relations;
Fourthly, to reveal the level of international representation of the Sami in the framework of the implementation of the construction of the transnational identity of the indigenous people;
Fifth, to determine the nature of the process of building identity through mixed quantitative and qualitative content analyzes of statutory documents of non-governmental Sami public organizations.
The object of the research is the national policy of the Russian Federation, the Kingdom of Norway, the Kingdom of Sweden, the Republic of Finland in relation to the indigenous people of the Far North - the Sámi. The subject of the research is the peculiarity of the formation of aspects of a transnational foreign policy tool - the national identity of the indigenous Sami minority people.
The scientific novelty of this study is determined by such factors as:
First, the author of the work comprehensively studied the national legislation of the four Arctic states in relation to the indigenous people;
Secondly, the author of the work through this study proposes the use of the identity process as a leading tool of foreign policy in the Arctic region;
Thirdly, for the first time, documents in dialects of the Sami language are introduced into scientific circulation. Also, sources in Norwegian, Finnish and Swedish were used.
The methodological basis of the study was general scientific and special methods. The author of the study used quantitative content analysis and qualitative content analysis to achieve the objectives.
Also, from the general scientific methods in this work are used such methods as: analysis, synthesis, induction, observation.
The author used the comparative legal method for comparing the legal framework of the modern legislation of the Russian Federation, the Kingdom of Norway, the Kingdom of Sweden, the Republic of Finland in relation to the indigenous people of the Far North Saami.
Characteristics of the source base.
The first group of sources consists of official legislative acts regulating and ensuring the realization of the rights of the indigenous Sami people in the territory of the Russian Federation, the Kingdom of Norway, the Republic of Finland, the Kingdom of Sweden.
The second group is represented by official international acts regulating the representation of the indigenous people.
The third group of sources combines the main official statutes and documents adopted and proclaimed by Sami non-governmental organizations.
The fourth group of sources is represented by articles of scientific periodicals, electronic journals describing the current situation of the people of the Far North.
The fifth group of sources contains monographs devoted to the theoretical substantiation of the phenomenon of identity and the sixth group of sources is represented by Internet resources on the topic covered.
The degree of knowledge of the topic.
Today, the topic of self-determination of the indigenous people of the Far North is determined by the literature used by the author of this work, the articles of domestic and foreign researchers who covered the topic of self-determination of the indigenous people in retrospect.
The greatest value for the study of self-determination of the indigenous people of the Far North of the Sami was provided by the works of such researchers as F. Akuts, N. Vukopov, V. Denisova, A. Silnikova, N. K, Kharlampyeva, and also the works of foreign authors, Wendt A., Anaya J., Lasswel H., Mitrany D., etc
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