239 research outputs found
Maternale Risikofaktoren bei Intrauterinem Fruchttod – eine Retrospektive Single Center Analyse über 18 Jahre
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Mathematical modeling of the heat transfer during pyrolysis process used for end-of-life tires treatment
No full textJunctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain
No full textThe type 1 ryanodine receptor (RyR1) in skeletal muscle is a homotetrameric protein that releases Ca2+ from the sarcoplasmic reticulum (SR) in response to an “orthograde” signal from the dihydropyridine receptor (DHPR) in the plasma membrane (PM). Additionally, a “retrograde” signal from RyR1 increases the amplitude of the Ca2+ current produced by CaV1.1, the principle subunit of the DHPR. This bidirectional signaling is thought to depend on physical links, of unknown identity, between the DHPR and RyR1. Here, we investigate whether the isolated cytoplasmic domain of RyR1 can interact structurally or functionally with CaV1.1 by producing an N-terminal construct (RyR11:4300) that lacks the C-terminal membrane domain. In CaV1.1-null (dysgenic) myotubes, RyR11:4300 is diffusely distributed, but in RyR1-null (dyspedic) myotubes it localizes in puncta at SR–PM junctions containing endogenous CaV1.1. Fluorescence recovery after photobleaching indicates that diffuse RyR11:4300 is mobile, whereas resistance to being washed out with a large-bore micropipette indicates that the punctate RyR11:4300 stably associates with PM–SR junctions. Strikingly, expression of RyR11:4300 in dyspedic myotubes causes an increased amplitude, and slowed activation, of Ca2+ current through CaV1.1, which is almost identical to the effects of full-length RyR1. Fast protein liquid chromatography indicates that ∼25% of RyR11:4300 in diluted cytosolic lysate of transfected tsA201 cells is present in complexes larger in size than the monomer, and intermolecular fluorescence resonance energy transfer implies that RyR11:4300 is significantly oligomerized within intact tsA201 cells and dyspedic myotubes. A large fraction of these oligomers may be homotetramers because freeze-fracture electron micrographs reveal that the frequency of particles arranged like DHPR tetrads is substantially increased by transfecting RyR-null myotubes with RyR11:4300. In summary, the RyR1 cytoplasmic domain, separated from its SR membrane anchor, retains a tendency toward oligomerization/tetramerization, binds to SR–PM junctions in myotubes only if CaV1.1 is also present and is fully functional in retrograde signaling to CaV1.1.</jats:p
Endogenous Information and Privacy in Automobile Insurance Markets
No full textThis paper examines the implications of insurers’ offering a voluntary monitoring technology to insureds in automobile insurance markets with adverse selection and without commitment. Under the consideration of the inherent costs related to the loss of privacy, the paper analyzes the incentives of insureds to reveal information, whereby they can decide how much or what quality of information to reveal. It is also allowed for the possibility that high risk individuals might mimic low risk individuals. The resulting market equilibrium is characterized and it is shown, that it will never be optimal for insureds to reject the monitoring technology and that under certain conditions, which are specified in the paper, it will be optimal for them to reveal complete information. Concerning the welfare effects both low risk and high risk individuals will always be better off. Unless it is optimal for individuals to reveal complete information, an all-or-nothing nature of the monitoring technology will not be efficient.adverse selection, privacy, insurance, risk classification, endogenous information acquisition
Endogenous Information and Privacy in Automobile Insurance Markets
No full textThis paper examines the implications of insurers’ offering a voluntary monitoring technology to insureds in automobile insurance markets with adverse selection and without commitment. Under the consideration of the inherent costs related to the loss of privacy, the paper analyzes the incentives of insureds to reveal information, whereby they can decide how much or what quality of information to reveal. It is also allowed for the possibility that high risk individuals might mimic low risk individuals. The resulting market equilibria are characterized and it is shown, that it might be optimal for insureds to reject the monitoring technology, but also that under certain conditions, which are specified in the paper, it might be optimal for insureds to reveal complete information. Concerning the welfare effects of introducing voluntary monitoring of insureds, if low risk individuals reject it, there will be no change to either risk type. If they accept it, this will make them better off and high risks may either be made better off or worse off depending on the initial equilibrium before a monitoring technology is offered. Unless it is optimal for individuals to reveal either zero or complete information, an all-or-nothing nature of the monitoring technology will not be efficient.adverse selection, privacy, insurance, risk classification, endogenous information acquisition
Variation in annual pollen accumulation rates of Fagus along a N–S transect in Europe based on pollen traps
No full textAnnual pollen-accumulation rates (PAR) of Fagus (beech) obtained within the framework of the Pollen Monitoring Programme (PMP) were analyzed in pollen traps along a N-S transect from the Baltic Sea to the Black Sea in different European vegetation units. The study regions are situated in the lowlands of northern Poland, the uplands of SE Poland, the Czech Krkonoe Mts, the Czech umava Mts, the Swiss Jura Mts, the Swiss Alps, the Bulgarian Rila Mts and the Bulgarian Strandzha Mts. Most time series are 10 or 11 years long, some are 5-16 years long. Inter-annual fluctuations in Fagus PAR were analyzed and compared with seed mast years. Years with high Fagus PAR and others with low Fagus PAR occurred most frequently in parallel within each region and often in two neighbouring regions. 2006 was exceptional as it had a very high Fagus sylvatica pollen deposition in all study regions and it was also a mast year. In Bulgaria, the trend in the 5 years of Fagus orientalis PAR in the Strandzha Mts differed from that of F. sylvatica PAR in the Rila Mts. Aiming at establishing the relationship between average Fagus PAR and tree cover, differences in Fagus PAR (averaged per pollen trap) were related in each region to the proportion of beech trees in the vegetation within 2 km of the pollen traps, the distance to the nearest pollinating Fagus tree, regional or local presence of beech forests, the degree of landscape openness, and the size of forest opening in which a trap is situated. Average Fagus PAR was found to track the regional abundance of beech trees in the vegetation, not the distance of the nearest Fagus tree. Regional occurrence of beech-dominated forests was reflected by a Fagus PAR of ca. 1,400 grains cm(-2) year(-1), local abundance very close to pollen traps by ca. 2,400 grains, small patches of forest with admixture of Fagus by ca. 170-220 grains, and scarcity or absence of Fagus by ca. 40 grains or less.PMP Sheila Hick
THE ROLE OF INTERPERSONAL, MASS MEDIA, AND INTERNET COMMUNICATION ON CHANGES IN SELF-REPORTED HEALTH BEHAVIOR AND SKILLS
No full textA Field Project submitted in partial fulfillment of the requirements for the degree of Master of Public Administration Health CareCommunication plays an integral role in changing health behaviors. Seeking
health related information from interpersonal, mass media, and Internet communication is
a common trend. Research on the use of the various communication channels for health
purposes reveals the mode of communication can influence an individual?s perception of
their health condition and ultimately their behavior.
This study focuses on whether personal health information found through the use
of interpersonal, mass media, or Internet communication changes one?s self-reported
health behavior and skills. A statistical analysis was completed using the 2007 Health
Tracking Household Survey conducted by the Center for Studying Health System Change
(HSC) between April 2007 and January 2008. The original sample includes 17,797
respondents from 9,407 U.S. families. The national sample was collected using computerassisted
random telephone interviews.
The literature suggests the channel used to obtain personal health information may
have an impact on self-reported health behaviors and health skills. Results of the
statistical analysis indicated the channels of communication used to obtain health
information did have an impact on self-reported health behavior and health skills. The
strongest predictors of health behavior change were obtaining personal health information
from books, the Internet and sharing personal health information with the healthcare
provider. Future research for policy makers should be directed toward integrating
traditional methods of obtaining personal health information and non-traditional methods
of obtaining health information with regard to changes in health behavior and health
skills
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