1,440 research outputs found
The Long-wavelength Earth model (LOWE) at 50 s Minimum Period
No full text<p>This repository holds an updated version of the Long-wavelength Earth Model (LOWE) as presented in Thrastarson et al. (2022). Since the original publication, the model has been further developed, with several full-waveform inversion updates down to a minimum period of 50 s. This version of LOWE in this repository is a submodel within the second generation of the Collaborative Seismic Earth Model (CSEM2, Noe et al. (submitted)).</p>
<p>Methodological developments and a description of the data are explained in detail in the publication about the final version of LOWE, now called REVEAL (Thrastarson et al., 2024).</p>
S288c
No full textCell-cell and cell-surface adherence represents initial steps in forming multicellular aggregates or in establishing cell-surface interactions. The commonly used Saccharomyces cerevisiae laboratory strain S288c carries a flo8 mutation, and is only able to express the flocculin-encoding genes FLO1 and FLO11, when FLO8 is restored. We show here that the two flocculin genes exhibit differences in regulation to execute distinct functions under various environmental conditions. In contrast to the laboratory strain Sigma 1278b, haploids of the S288c genetic background require FLO1 for cell-cell and cell-substrate adhesion, whereas FLO11 is required for pseudohyphae formation of diploids. In contrast to FLO11, FLO1 repression requires the Sin4p mediator tail component, but is independent of the repressor Sfl1p. FLO1 regulation also differs from FLO11, because it requires neither the KSS1 MAP kinase cascade nor the pathways which lead to the transcription factors Gcn4p or Msn1p. The protein kinase A pathway and the transcription factors Flo8p and Mss11p are the major regulators for FLO1 expression. Therefore, S. cerevisiae is prepared to simultaneously express two genes of its otherwise silenced FLO reservoir resulting in an appropriate cellular surface for different environments
Electronic properties of Cs+CO coadsorbed on the Ru(0001) surface
No full textThe variation of the Cs 6s and the Cs 5p emission in He* and Ne* metastable deexcitation spectroscopy (MDS) as a function of the CO exposure indicates a demetallization of the Ru(0001)-(2x2)-Cs and the Ru(0001)-(root 3x root 3)R30 degrees-Cs surfaces upon CO coadsorption. This observation corroborates a (substrate-mediated) charge transfer from the Cs atom to the 2 pi* orbital of CO. With the Ru(0001)-(2x2)-Cs system even at CO saturation, MD spectra show emission associated with the Cs 6s state, indicating that the Cs atoms are not completely ionized, Exposing the (root 3x root 3)R30 degrees-Cs-pre-covered Ru(0001) to CO, surplus Cs of the first layer is displaced into a second layer In this way, CO molecules are able to be accommodated into the first layer, Desorbing this second layer Cs by heating the sample to 600 K produces a (2x2) structure with one Cs and CO in the unit cell as evidenced by MDS and low energy electron diffraction
Characterisation and macro-modeling of patterned micronic and nano-scale dummy metal-fills in integrated circuits
No full textIn this paper, a wideband characterization and macro-modeling of patterned micronic and nano-scale dummy
metal-fills is presented. Impacts of patterned dummy metal-fill topologies including square, cross, vertical and horizontal shaped arrays on electrical performances
(isolation/coupling, attenuation, guiding properties, etc…) are investigated. The validity of the proposed macro-modeling methodology is demonstrated by comparison with high frequency measurements of dedicated carrier structures including on-chip interconnects and RF inductive loops. An original extraction approach, based on local ground concept, is proposed to capture high frequency behaviour of dummy metal-fill in physics-based compact broadband SPICE model. The RLC parameters are accurately derived using fully scalable closed-form semi-analytical expressions
Semantic enrichment of a point cloud based on an octree for multi-storey pathfinding
No full textAcquiring point clouds of indoor environments became increasingly accessible in recent years. However, the resulting 3D point cloud data is unstructured, and does not contain enough information to be useful for complex tasks like pathfinding. Indoor models which are currently derived from point clouds do not include furniture and stairs. The necessary graph to enable multi-storey pathfinding is not available in the point cloud. This thesis proposes a workflow to semantically enrich indoor point clouds using an octree data structure. Meaning is added to the point cloud scene that allows to act as a basis for a graph. This graph can then follow navigation constraints of humans through an indoor environment. The approach for semantic enrichment of this study is capable of separating storeys, detecting floors, walls, stairs and obstacles like furniture. Strict preconditions are used, like walls being perpendicular to each other and using noise free point clouds. The implementation works as a proof of concept and the octree proves to be a helpful data structure. The contribution is a novel approach of using octrees for the semantic enrichment of indoor point clouds, including the detection of stairs. Combining and extending different works from various fields of research helped to develop the presented methodology. The semantic classification of floors and stairs in 3D point clouds allows to create a graph across multiple storeys. A big part of the methodology was implemented and tested on different types of buildings and scanned with dissimilar kinds of laser scanners. Mobile scanners were found to be advantageous, because they are less dependent on the line of sight. On top of that, they can provide a path of the scanner, which is precious information that can support several structuring improvements of the acquired data. The octree generalises the point cloud to leafs and adds a structure to the empty space. This does not only improve the calculation performance, but also provides more distinguishable results. Concluding, the thesis proposes to extent the framework to cover a wider range of architectural structures. Furthermore, future research should deepen the knowledge for the stair detection of the presented conceptual framework. As the representation of stairs differ for every scanner, future research should focus on point clouds acquired by one kind of scanner first.Architecture and The Built EnvironmentUrbanism3D Geo-Informatio
The proposal for optimalization of the E-commerce of ANKA M+N spol. s r.o.
No full textBakalářská práce je zaměřena na komplexní analýzu firmy Anka M + N spol. s r.o. a jejího internetového obchodu, ze které vychází návrh na optimalizaci elektronického obchodu zajišťující firmě větší konkurenceschopnost a z ní vyplývající prosperitu.Bachelor’s thesis is focus on complex analysis of Anka M+N spol. s r.o. and it’s electronic shop, from which appears proposal for optimalization of the e-commerce ensuring major competitive strength and resultant prosperity for the company.
Experimental investigation of self-heating effects in semiconductor resistors during TLP pulses
No full textThe purpose of this work is the experimental extraction of the local maximum temperature occurring in
silicon resistors when a transmission line pulse is applied. The local temperature is extracted by combining transmission line pulses of
different amplitude and at different ambient temperatures with two-dimensional electrothermal simulation. This investigation has
relevant practical applications. The obtained calibration curves enable to convert the phase shift information as obtained by
interferometric techniques (e.g. in Transient Interferometric Mapping) into absolute temperature readings. Moreover, relevant physical
parameters (e.g. resistivity) can be extracted as a function of the temperature by transient heating, i.e. by avoiding the detrimental
artifacts involved with the static heating of semiconductor samples at high temperatures. This enables to calibrate device simulators at
those high temperatures, which are required for the simulation of ESD events
Vescicole extracellulari nel contesto dell'aterosclerosi = Extracellular vesicles in atherothrombosis
No full textLe vescicole extracellulari (VEs) sono una popolazione eterogenea di nano-particelle rilasciate nella maggior part
dei fluidi biologici da quasi tutti i tipi cellulari, sia in condizioni fisiologiche che di malattia. Essendo in grado di
trasportare un contenuto molecolare (tra cui proteine, acidi nucleici, e persino organuli interi e/o frammentati) da
una cellula donatrice a una ricevente, le VEs non solo svolgono un ruolo fondamentale nella comunicazione paracrina
ed endocrina tra cellule, ma rappresentano una fonte importante di informazioni di tipo molecolare. Queste caratteristiche
rendono le VEs particolarmente interessanti nell’ambito dei processi fisiopatologici in ambito cardiovascolare.
Difatti, alterazioni significative nella quantità, nella dimensione e nel contenuto proteico potrebbero associarsi
con specifiche caratteristiche fisiopatologiche, tra cui, ad esempio, la severità del grado di danno endoteliale.
Di conseguenza, le VEs godono di un potenziale clinico di notevole importanza e rappresentano un’impronta
molecolare specifica utile sia in termini diagnostici che prognostici. Monitorando le caratteristiche delle VEs è
possibile valutare l’insorgenza e l’andamento di determinate patologie ‘silenti’, come ad esempio l’aterosclerosi. In
determinati contesti cardiovascolari, le VEs svolgono anche ruoli rigenerativi e riparatori. Ovviamente saranno
necessari ulteriori studi e l’applicazione di nuove tecnologie per far sì che le VEs possano essere considerate veri e
propri strumenti sia di diagnosi che di prognosi nell’ambito delle patologie a eziologia aterosclerotica.Extracellular vesicles (EVs) are a heterogeneous group of nanoparticles released by almost all cell types into most
biological fluids, under both physiological and pathological conditions. Given their ability of transporting molecular
content (including proteins, nucleic acids, lipids, and even whole and/or fragmented organelles) from a donor cell
to a recipient cell, EVs not only play a key role in paracrine and endocrine intercellular communication, but also
represent an important source of molecular information that would otherwise be difficult to obtain. These charac-
teristics render EVs particularly interesting in the context of the pathophysiological processes of cardiovascular
diseases. Indeed, numerous studies demonstrate how significant alterations of certain EV aspects, such as circulat-
ing concentration, size, and protein content, associate with specific features of disease, including, for example, se-
verity. Consequently, EVs yield significant clinical potential as tools that may assist on a molecular level in the diag-
nosis and monitoring of various diseases. In addition to their potential diagnostic role, EVs also represent promis-
ing fingerprints in the clinical setting from a prognostic point of view. By monitoring the phenotypic characteristics
of EVs, it is possible to assess the onset and progression of certain ‘silent’ diseases, such as for instance atheroscle-
rosis. In certain cardiovascular settings, EVs also play regenerative and reparative roles. Extensive further studies
and development of new technologies will be essential to establish EVs as practical tools for a routinely diagnostic
clinical use
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