703 research outputs found
Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever
No full textPublished source: Bremner, S. A., Carey, I. M., DeWilde, S., Richards, N., Maier, W. C., Hilton, S. R., Strachan, D. P. and Cook, D. G. (2007), Vaccinations, infections and antibacterials in the first grass pollen season of life and risk of later hayfever. Clinical & Experimental Allergy, 37: 512–517. doi: 10.1111/j.1365-2222.2007.02697.
The evolution of extracellular hemoglobins of annelids, vestimentiferans, and pogonophorans.
No full textThe evolution of extracellular hemoglobins of annelids, vestimentiferans, and pogonophorans was investigated by applying cladistic and distance-based approaches to reconstruct the phylogenetic relationships of this group of respiratory pigments. We performed this study using the aligned sequences of globin and linker chains that are the constituents of these complex molecules. Three novel globin and two novel linker chains of Sabella spallanzanii described in an accompanying paper (Pallavicini, A., Negrisolo, E., Barbato, R., Dewilde, S., Ghiretti-Magaldi, A., Moens, L., and Lanfranchi, G. (2001) J. Biol. Chem. 276, 26384--26390) were also included. Our results allowed us to test previous hypotheses on the evolutionary pathways of these proteins and to formulate a new most parsimonious model of molecular evolution. According to this novel model, the genes coding for the polypeptides forming these composite molecules were already present in the common ancestor of annelids, vestimentiferans, and pogonophorans
The Evolution of Extracellular Hemoglobins of Annelids, Vestimentiferans, and Pogonophorans.
No full textThe evolution of extracellular hemoglobins of annelids, vestimentiferans, and pogonophorans was investigated by applying cladistic and distance-based approaches to reconstruct the phylogenetic relationships of this group of respiratory pigments. We performed this study using the aligned sequences of globin and linker chains that are the constituents of these complex molecules. Three novel globin and two novel linker chains of Sabella spallanzanii described in an accompanying paper (Pallavicini, A., Negrisolo, E., Barbato, R., Dewilde, S., Ghiretti-Magaldi, A., Moens, L., and Lanfranchi, G. (2001) J. Biol. Chem. 276, 26384--26390) were also included. Our results allowed us to test previous hypotheses on the evolutionary pathways of these proteins and to formulate a new most parsimonious model of molecular evolution. According to this novel model, the genes coding for the polypeptides forming these composite molecules were already present in the common ancestor of annelids, vestimentiferans, and pogonophorans
A Review of "Housing wealth and welfare", By Caroline Dewilde and Richard Ronald
No full textBook review: Housing wealth and welfare, By Caroline Dewilde and Richard Ronald, Cheltenham, Edward Elgar Publishing, 2017, ISBN 978 78536 095 4.This is a very interesting edited volume comprising an introduction chapter reflecting on so-called housing asset-based welfare and nine chapters written by a nice selection of authors. It is a more than worthwhile joint effort of two excellent ERC laurates who have both been working on the topic for years which is demonstrated in the very comprehensive overview of the state of the art in housing wealth and welfare. They explain different models across time and across Europe: some models are more familialised, relying on family capital, while others are more financialised, relying on mortgages. The introduction is followed by a multi-angle, multi-country collection of well-written chapters. And last but not least, there is an epilogue by John Doling, ‘the father’ of housing asset-based welfare.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.OLD Housing System
Time-domain coding of (near) toll quality speech at rates below 16 KB/s
No full textElectrical Engineering, Mathematics and Computer Scienc
Emotions and stress increase respiratory resistance in asthma
No full textObjectives: Clinical reports suggest that various emotions and types of stress can precipitate asthmatic symptoms, but there is little experimental evidence to substantiate this claim. We studied the impact of different emotional states and stress on respiratory resistance in asthmatic and nonasthmatic individuals. Methods: Participants (24 asthmatic and 24 nonasthmatic patients) viewed short film sequences selected to induce anxiety, anger, depression, elation, happiness, contentment, or a neutral affective state and completed two stressful tasks, mental arithmetic to induce active coping efforts and viewing of medical slides to induce passive coping efforts. Oscillatory resistance, heart rate, blood pressure, baroreflex sensitivity, skin conductance level, respiration rate and volume, and self-reported affective state were measured throughout the session. Results: Uniform increases in oscillatory resistance were found in all emotional states compared with the neutral state and during mental arithmetic in both groups. Asthmatic patients showed stronger reactions to the medical slides than healthy control subjects, with significant increases in oscillatory resistance, blood pressure, skin conductance level, and minute volume, as well as higher levels of self-reported depression, arousal, and shortness of breath. Changes in oscillatory resistance were inconsistently correlated with other physiological indices. Conclusions: Various emotional states and stress increase oscillatory resistance largely independently of concurrent increases in autonomic or ventilatory activity. The particular sensitivity of asthmatics to passive coping demand requires additional research
Protoglobins : novel features from an ancient globin
No full textVery recently a new subfamily of globins, called protoglobins, have been identified in the genome sequences of the Actinobacterium Thermobifida fusca, the green non-sulfur bacterium Chloroflexus aurantiacus, and the two Archaea Aeropyrum pernix (ApPgb) and Methanosarcina acetivorans (MaPgb). Both ApPgb and MaPgb have been partly characterized and demonstrated to conform to the globin sequence motifs, to contain heme, and to bind CO, NO, and O2 in the ferrous form, being very oxygen-sensitive [1]. Their broad ligand range and their sensitivity to oxygen predisposes protoglobins to functioning in low oxygen environments. Thus they appear to be the molecular fossil that thus far, most closely resembles the haemoglobin that was present in organisms possibly as far back as the Last Universal Common Ancestor, or LUCA.
A phylogenetic analysis has suggested that protoglobins are the ancestral protein of the globin-coupled sensors (GCSs) [2]. GCSs were first described as regulators of the aerotactic responses in Bacillus subtilis and Halobacterium salinarum (heme-based aerotaxis transducers: HemATs), but also identified in diverse microorganisms that appear to have roles in regulating gene expression. MaPgb and ApPgb are both exactly 195 amino acids long, the same length of the globin domain in archaeal GCS aerotaxis transducer HemATs. The HemATs globin domain, however, retains bound oxygen for much longer periods of time than the protoglobins [3]. This evidence indicates that the protoglobins are not simple equivalents of the liberated GCS globin domains and that there is a fundamental structural and/or functional difference between the two.
Here, we report here the first crystal structure of a protoglobin, from Methanosarcina acetivorans, and we analyse how it correlates to the classical globin fold and to its functionally-related globin-coupled sensors. The protein structure MaPgb was solved by means of multiple wavelength anomalous diffraction (MAD), based on the anomalous scattering of the iron atom. The protein model was refined at 1.3 Å resolution using data collected at the remote wavelength during the MAD experiment performed at the ESRF ID23-1 beamline
Cognition in Clients With Acute High-Level Spinal Cord Injury: Why Assessment Matters
No full textAbstract
Date Presented 3/30/2017
A literature review found the incidence of cognitive impairment in those with high-level SCI to be 70%–77% from brain injury and other comorbidities. These impairments are often overlooked. Cognitive screening is essential for appropriate care, but there is a shortage of appropriate assessments.
Primary Author and Speaker: Susan Doyle
Additional Authors and Speakers: Tatiana Kaminsky
Contributing Authors: Michael DeWilde, Jon-Erik Golob, Olivia Allen</jats:p
A Hybrid Element Method For Calculation Of Capacitances From The Layout Of Integrated Circuits
No full textWe describe a hybrid method which combines the boundary element method (BEM) and the finite element method (FEM) to compute circuit models for layout dependent capacitances. The method can handle irregularities in the stratification of the layout of the integrated circuits (IC's). New in the method are the models for the interface between the regions where the BEM and the FEM are applied. We show fast convergence of the method and give 2D and 3D simulation results which confirm its validity. 1 Introduction Parasitic interconnect capacitances in integrated circuits have significant influence on circuit performance. To verify correct behavior of IC's before costly fabrication, these capacitances must be calculated (extracted) from the layout design (geometry) of the circuit. The most popular techniques used for capacitance extraction are the BEM (Brebbia[2], Ruehli[5], Dewilde[3]) and the bulk FEM (Silvester[7]). For regular media as depicted in Fig.(1a), the BEM is computationally more..
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