134 research outputs found
Efficacia ipotensiva oculare della brimonidina in pazienti con IOP non controllata con beta-bloccanti
No full textGli Autori valutano gli effetti della sostituzione dei beta-bloccanti con la Brimonidina nella terapia locale di pazienti glaucomatosi con pressione oculare sotto trattamento> 20 mmHg. Lo studio è a due bracci: un gruppo trattato con Brimonidina b.i.d. (23 pazienti) ed un gruppo trattato con Brimonidina e Dorzolamide b.i.d. (17 pazienti). Gli effetti della sostituzione dei beta-bloccanti con la Brimonidina ha dimostrato, dopo 90 giorni di trattamento, una riduzione di 8,59 +/- 1,2 mmHg (P < 0.001) nel secondo. Nel primo gruppo, e 6,1 +/- 1,7 mmHg (P < 0.001) nel secondo. Nel primo gruppo 3 pazienti, nel secondo 4, hanno presentato lievi reazioni avverse, che non hanno richiesto l'interruzione del trattamento.The authors evaluate the effects of the substitution of beta-blockers with brimonidine in the local treatment of glaucomatous patients affected with ocular pressure equal to < 20 mmHg undergoing treatment. The study included a group treated with brimonidine b.i.d. (23 patients) and one treated by brimonidine and dorzolamide b.i.d. (17 patients). The effects of the substitution of beta-blockers with brimonidine showed that after 90 days of treatment there was a reduction by 8.59 +/-1.2 mmHg (p < 0.001) in the first group, while in the second group, 4 presented with mild adverse reactions that did not, however, require interruption ot treatment
The evolution of the Western Adriatic margin and contiguous oceanic area: new problems and working hypotheses
No full textVALUTAZIONE DELLE VARIAZIONI DELLA PRESSIONE ARTERIOSA DI PAZIENTI GLAUCOMATOSI IN TRATTAMENTO CON BETA-BLOCCANTI
No full textNOUVELLE DATATION ET INTERPRÉTATION DE LA SUCCESSION SÉDIMENTAIRE DE FIUMARA SANT'ANGELO (MONTS PÉLORITAINS; ITALIE MÉRID.LE):CONSÉQUENCES POUR LA PALÉOGÉOGRAPHIE MÉSOZOÏQUE DE LA MEDITERRANÉE CEN.LE
No full textDiagnostic capability of optic nerve head rim width and retinal nerve fiber thickness in open-angle glaucoma
No full textPURPOSE:
This study was performed to test the diagnostic capability of the minimum rim width compared to peripapillary retinal nerve fiber layer thickness in patients with glaucoma.
METHODS:
A case control, observer masked study, was conducted. Minimum rim width and retinal nerve fiber layer thickness were assessed using the patient-specific axis traced between fovea-to-Bruch's membrane opening center axis. For both minimum rim width and retinal nerve fiber layer thickness, the regionalization in six sectors (nasal, superior-nasal, superior-temporal, temporal, inferior-temporal, and inferior-nasal) was analyzed. Eyes with at least one sector with value below the 5% or 1% normative limit of the optical coherence tomography normative database were classified as glaucomatous. The area under the receiver operator characteristic curve, the accuracy, sensitivity, specificity, and predictive positive and negative values were calculated for both minimum rim width and retinal nerve fiber layer thickness.
RESULTS:
A total of 118 eyes of 118 Caucasian subjects (80 eyes with open-angle glaucoma and 38 control eyes) were enrolled in the study. Accuracy, sensitivity, and specificity were 79.7%, 77.5%, and 84.2%, respectively, for minimum rim width and 84.7%, 82.5%, and 89.5% for retinal nerve fiber layer thickness. The positive predictive values were 0.91% and 0.94% for minimum rim width and retinal nerve fiber layer thickness, respectively, whereas the negative predictive values were 0.64% and 0.70%. The area under the receiver operator characteristic curve was 0.892 for minimum rim width and 0.938 for retinal nerve fiber layer thickness.
CONCLUSION:
Our results indicated that the sector analysis based on Bruch's membrane opening and fovea to disk alignment is able to detect glaucomatous defects, and that Bruch's membrane opening minimum rim width and retinal nerve fiber layer thickness showed equivalent diagnostic ability
The effects of 2% ipobamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma
No full textPURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders.
METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops.
RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes.
CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders
"Effects of a Fixed combination of Timolol and Dorsolamide on ocular hypertension"
No full textRelazione al 3rd International Symposium on Ocular Pharmacology and Pharmaceutics (ISOPP). Lisbon,Portugal,10-13 .2 .2000
New biostratigraphic evidences in the central-eastern belt of the Vardar Zone (Internal Dinarides). In: Tra Alpi, Dinaridi e Adriatico; Atti dell’ 80a Riunione Estiva S.G.I. Carulli & Ponton (Eds).
No full text
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