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Simultaneous occurrence of multiple trichoblastomas and steatocystoma multiplex
No full textWe present a 55-year old man who, since age 21, progressively developed multiple papules and nodules on the face and upper trunk. Light microscopic examination of some of the neoplasms showed trichoblastomas, while others had histopathological features of trichoepithelioma and steatocystoma. Simultaneous occurrence of multiple trichoblastomas/trichoepitheliomas and steatocystomas, not reported previously, could represent multiple neoplasms involving differentiation toward different components of the folliculosebaceous unit
Metastasi cutanea di adenocarcinoma esofageo : descrizione di un caso clinico
No full textSkin metastasis of digestive tumors is rarely encountered. In this paper the Authors describe a 60 years old patient who developed a submental skin metastasis from esophageal adenocarcinoma. A short literature review this unusual pathological event is also given
Dermatite psoriasiforme indotta da atenololo
No full textWe report the case of a patient who presented a psoriasiform dermatitis after 8 months of atenolol therapy. Regression of the lesions was obtained after suspension of therapy. To our knowledge, few reports of psoriasiform dermatitis induced by atenolol are present in the literature. The Authors briefly discuss the pathogenesis of this drug induced disease
Laugier-Hunziker syndrome: a clinical, histopathologic, and ultrastructural study of four cases and review of the literature
No full textFour cases of Laugier-Hunziker syndrome are described. In all patients (two men and two women between 39 and 57 years of age) pigmentation of the lower lip and hard palate was found. In addition, two patients had involvement of the buccal mucosa; another patient also had pigmentation of the upper lip, the gums, the soft palate, and the fingers of both hands. Histopathologic examination demonstrated an accumulation of melanin in the basal layer keratinocytes and an increase in the number of melanophages in the papillary dermis. Ultrastructural study showed the presence of numerous mature melanosomes in the cytoplasm of the keratinocytes of the basal layer and of the melanophages in the papillary dermis. Alterations of the melanocytes were not observed
Normolipemic plane xanthomas and IgG-k multiple myeloma : description of a clinical case
No full textThe Authors describe the case of a woman affected by generalized plane xanthoma and IgG multiple myeloma with k type immunoglobulins. The association between the two affections is well known. The antilipoprotein activity of the paraprotein has been proved in some cases, associated or not to hyperlipemia. The pathogenetic mechanism of plane xanthoma formation is described briefly. The possible occurrence of plane xanthoma with multiple myeloma is stressed, along with the possible association with other systemic diseases
Primary cutaneous pleomorphic T-cell lymphoma expressing CD30 antigen
No full textPleomorphic peripheral T-cell lymphomas (PPTL) arising primarily in the skin are uncommon. The observation of pleomorphic T-cell lymphoma composed of 100% CD30+ cells is rare. We report the case of a woman in whom such a tumor manifested itself with a single cutaneous lesion. It was composed of medium to large cells expressing markers of helper/inducer T-lymphocytes, as well as activation (CD30) and proliferation antigens (Ki-67), but not the CD25 activation antigen. The lesion was excised and the patient is alive and disease free 2 years after the diagnosis. This case confirms previous reports about the favorable course of some cutaneous pleomorphic lymphomas, and shows that the activation antigen expression and proliferation antigen (Ki-67) expression do not seem to worsen the prognosis
Acral persistent papular mucinosis in two sisters
No full textWe describe two young sisters with an asymptomatic papular eruption on the forearms, the clinical, histopathological and ultrastructural features of which were consistent with acral persistent papular mucinosis. Familial occurrence of this uncommon disease is exceptional
Morbilliform exanthem induced by imiquimod in a patient with drug-related immunosuppression
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