392 research outputs found
Scenic Roots:Curator
No full textScenic Roots is a group exhibition, at Townhall Cavan, exploring rural life, queer identity, folklore, biodiversity, sustainability, the Anthropocene, and social and cultural influence through drawing and sculpture.With artists Kian Benson Bailes, Laura Fitzgerald, Lisa Fingleton, Siobhán McGibbon, and Maria McKinney, curated by Laura O’Connor
Scenic Roots:Curator
No full textScenic Roots is a group exhibition, at Townhall Cavan, exploring rural life, queer identity, folklore, biodiversity, sustainability, the Anthropocene, and social and cultural influence through drawing and sculpture.With artists Kian Benson Bailes, Laura Fitzgerald, Lisa Fingleton, Siobhán McGibbon, and Maria McKinney, curated by Laura O’Connor
Evaluation of Diabetes Advisory System (DIAS) by a double blind controlled clinical trial:a necessary step?
No full textThe Australia-US alliance: a cost/benefit analysis
No full textKey Points
It is time for a hard-headed cost/benefit analysis of the US Alliance. Any such analysis should include the following questions:
Does the Alliance create more problems than it solves?
In the Indo-Pacific Region, do we want a balance between the US and China, or US dominance?
What intelligence do we get from the US that would still be needed without the Alliance?
Summary
The American alliance is an article of faith in Australia because it is said to underpin our security. There have been many reviews and White Papers but perhaps it is time for a hard-headed cost/benefit analysis. Here I consider some of the questions that must be asked.
About the Author
Cavan Hogue was Ambassador and Deputy Permanent Representative when Australia was last on the United Nations Security Council. He has also served as head of mission in Mexico, Kuala Lumpur, Moscow and Bangkok, as well as holding senior positions in other posts and in Canberra. He is now an Adjunct Professor in International Communication at Macquarie University, Sydney
A positive correlation between the total daily dosage of intermediate acting insulin and the magnitude of hypoglycaemic counter-regulations in insulin dependent diabetes indicated by a model based statistical analysis
No full textUsing the Diabetes Advisory System (DIAS) to provide patient specific advice on insulin dose to prevent hypoglycaemia
No full text
Generation of iPSC line from a Joubert syndrome patient with compound heterozygous mutations in CPLANE1 gene
No full textWe generated iPSC line using skin fibroblasts obtained from a female patient affected by Joubert syndrome, caused by two compound heterozygous variants (c.143G > A; p.Gly48Glu and c.1784 T > G; p.Leu595Ter) in CPLANE1. We used Sendai -virus -based technique for reprogramming and then we applied karyotype analysis, to exclude possible acquired big rearrangements. We verified the presence of the same STR profile as fibroblasts, the stem cell state (by immunofluorescence and qPCR) and, finally, the pluripotency state (by in vitro trilineage differentiation)
The Sensitivity of Subsurface Microbes to Ocean Warming Accentuates Future Declines in Particulate Carbon Export
No full textUnder future warming Earth System Models (ESMs) project a decrease in the magnitude of downward particulate organic carbon (POC) export, suggesting the potential for carbon storage in the deep ocean will be reduced. Projections of POC export can also be quantified using an alternative physiologically-based approach, the Metabolic Theory of Ecology (MTE). MTE employs an activation energy (Ea) describing organismal metabolic sensitivity to temperature change, but does not consider changes in ocean chemistry or physics. Many ESMs incorporate temperature dependent functions, where rates (e.g., respiration) scale with temperature. Temperature sensitivity describes how temperature dependence varies across metabolic rates or species. ESMs acknowledge temperature sensitivity between rates (e.g., between heterotrophic and autotropic processes), but due to a lack of empirical data cannot parameterize for variation within rates, such as differences within species or biogeochemical provinces. Here we investigate how varying temperature sensitivity affects heterotrophic microbial respiration and hence future POC export. Using satellite-derived data and ESM temperature projections we applied microbial MTE, with varying temperature sensitivity, to estimates of global POC export. In line with observations from polar regions and the deep ocean we imposed an elevated temperature sensitivity (Ea = 1.0 eV) to cooler regions; firstly to the Southern Ocean (south of 40°S) and secondly where temperature at 100 m depth <13°C. Elsewhere in both these scenarios Ea was set to 0.7 eV (moderate sensitivity/classic MTE). Imposing high temperature sensitivity in cool regions resulted in projected declines in export of 17 ± 1% (< 40°S) and 23 ± 1% (< 13°C) by 2100 relative to the present day. Hence varying microbial temperature sensitivity resulted in at least 2-fold greater declines in POC export than suggested by classic MTE derived in this study (12 ± 1%, Ea = 0.7 eV globally) or ESMs (1–12%). The sparse observational data currently available suggests metabolic temperature sensitivity of organisms likely differs depending on the oceanic province they reside in. We advocate temperature sensitivity to be incorporated in biogeochemical models to improve projections of future carbon export, which could be currently underestimating the change in future POC export
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