17 research outputs found
VACCINE-INDUCED DEVELOPMENTAL DELAY: A CASE REPORT
Full text linkVaccines are weakened or dead microbes injected for the development of an acquired immunity as a preventive measure, also including the use of microbial proteins. The spectrum of adverse events following vaccination has been increasing as well with increasing number of reports detailing the events following immunization. The rate of morbidity and mortality of many communicable diseases has significantly decreased with time with relieve to the quality of life as well as the overall pharma economic cost. In this case report vaccine-induced developmental delay was observed in a child of 16 months of age. The child was born with low birth weight despite which the child was administered with hepatitis B vaccine, poliomyelitis vaccine, and bacillus Calmette-Guerin within 24 h of birth. Consecutive clinical outcomes followed throughout the years, which induced a developmental delay in this child. This case clearly signifies the need for more evidence-based implementation for the management of various diseases at secondary care hospitals
Saussurea lappa (Kuth root): review of its traditional uses, phytochemistry and pharmacology
No full textAssessment of adverse drug reactions based on spontaneous signals at secondary care public hospital
No full textA Phenytoin Induced Toxic Epidermal Necrolysis (TEN) -A Case Report
No full textA B S T R A C T Toxic Epidermal Necrolysis (TEN) is a rare, potentially life threatening dermatological condition that is usually induced by medications. The usage of anticonvulsants like carbamazepine, phenytoin, lamotrigine, phenobarbital, fosphenytoin are associated with high risk for occurrence of TEN. A 36 year old female patient was brought with the history of Phenytoin induced Toxic Epidermal Necrolysis. This patient was prescribed tablet phenytoin 300mg/day, 100mg in the morning and 200mg at night for her generalized tonic-clonic seizure disorder and patient had history of using the drug for a period of 28 days. Patient developed macular rashes on the skin and consulted a general physician who prescribed her with cetirizine 5mg, bid. The drug phenytoin was continued till she visited Government District Head Quarters Hospital,Udhagamandalam in spite of treatment with cetirizine the rashes spread all over the body with an additional ocular redness with discharge. This case report describes the management of this patient
Essential Medication Prescription and Associated Maternal Characteristic among Hospitalized Pregnant Women: A Retrospective Population Based Study
No full textEthnopharmacology and integrative medicine - Let the history tell the future
No full textTraditional systems of medicines need more evidence-based studies on both crude drugs and purified phytomolecules. Utilization of natural products as pharmacological tools could lead to a number of new major therapeutically active metabolites. Lead molecules are further screened for their potential in terms of quality control, safety assessments, and studies about molecular pharmacology and their related properties. Identification, and quality and safety evaluation of natural products, is a fundamental requirement of industry and other organizations dealing with natural health products (NHPs). Marker analysis, based on chemo-profiling and development of characteristic fingerprints for individual plants, could help to develop uniform standardization tools. Beside such evaluations of clinical parameters, safety profiles as well as drug-herb and herb-herb interactions are the most important parameters for assessment and promotion. With the steady growth of the NHPs, advanced analytical- and mechanism-based screening should be considered for their promotion and value addition in every way for the betterment of healthcare. Thus, there is an urgent need for the development of international co-ordination to promote and develop NHPs, including their assessment, perspectives, pharmacovigilance, and potential harmonization of regulation, quality control and clinical uses
Knowledge, Attitude and Practice of Community Pharmacists towards Cognitive Pharmaceutical Care Services in Tamil Nadu, India
No full text
Effect of Nadi Shuddhi Pranayama, Kati Chakrasana and Vakrasana on Depression and Glycemic Control in Type 2 Diabetes Mellitus
No full textShort COMMUNICATION Cytochrome P450 Inhibition Assay for Standardized Extract of Terminalia chebula Retz.ptr_2993 151..154
No full textThe hydroalcoholic extract of fruit pulp of Terminalia chebula Retz. was standardized and evaluated for its
safety through cytochrome P450 (CYP 450) inhibition assay. Standardization was performed through high
performance thin layer chromatography (HPTLC) using gallic acid (GA) standard. Cytochrome P450-CO
complex microplate assay was performed using rat liver microsomes. The effect of standardized extract, its
fraction and bioactive marker compound were comparatively evaluated for its effect on CYP P450 enzymes.The
extract of fruit pulp was used for HPTLC,where the Rf value of the marker was found to be 0.43.The calibration
plot was linear in the range of 2–14 mg of GA and correlation co-efficient of 0.99965. The mean quantity of GA
was found to be 2.5% w/w.The CYP P450 concentration of the rat liver microsome sample used in the study was
found to be 0.417 nmol/mg protein.The in vitro effect of various concentrations of extracts and fractions showed
a linear concentration-dependent inhibition of cytochrome P450 up to 60 mL. The study showed more inhibition
of fraction when compared to the extract and GA. Still, the inhibition showed by fraction is less when compared
with standard Ketoconazole. Thus, this study indicated the in vitro cytochrome P450 inhibition potential of T.
Chebula. Copyright © 2010 John Wiley & Sons, Ltd
