924 research outputs found
Luciano Giaccari e lo Studio 970 2 di Varese (1967-1977)
No full textLa ricerca ha per oggetto l'osservazione, l'analisi e la ricostruzione della figura di Luciano Giaccari e della sua attività sviluppata con lo Studio 970 2 a Varese tra il 1967 e il 1977. L'intento è quello di mostrare come il centro fosse nato come laboratorio artistico, entro il quale Giaccari organizza cinque manifestazioni peculiari - "24 ORE di NO STOP THEATRE" (1968), "Opere di Neve" (1969), "Opere di Fumo" (1969), "Esperimento di Nuovo Teatro" (1969) e "interVENTO" (1970) - legate alla necessità di sviluppare un contesto culturale alternativo agli spazi più 'ufficiali'. E' in questa realtà che contestualmente emerge in Giaccari l'interesse germinante per la sperimentazione video, attivata concretamente solo a partire dal 1971, anno in cui è acquisita la strumentazione relativa e lo Studio 970 2 viene trasformato in centro di produzione videografica, uno dei primi in ambito italiano. La ricerca mira quindi a ricostruire l'intera attività compiuta da Giaccari e le diverse linee di lavoro: l'inserimento nel settore della controinformazione (1971-1973), la produzione di videotape di artisti italiani e stranieri (1971-1975) e la realizzazione di documentazioni in video di molteplici performance artistiche (1971-1977). Come anche il contributo critico e teorico che egli offre alla materia al principio degli anni Settanta, particolarmente grazie alla stesura della "Classificazione dei modi d'impiego del videotape in arte" (1973)
Weyl transformations and trace anomalies in N=1, D=4 supergravities
No full textWe consider the supersymmetric extension of Weyl transform
ations in various
types of supergravities, the minimal, 20+20 and 16+16 nonmi
nimal N=1 SUGRA in 4D,
formulated in terms of superfields and study their local coho mology. Based also on previous results we conclude that there are only two types of trace anomalies in 20+20 and
16+16 nonminimal supergravities, which correspond to the two nontrivial cocycles of the
minimal supergravity and, when reduced to component form, to the well-known squared
Weyl density and Euler density
Generalized States in SFT
No full textThe search for analytic solutions in open string
fields theory à la Witten often meets with singular expres-
sions, which need an adequate mathematical formalism to
be interpreted. In this paper we discuss this problem and
propose a way to resolve the related ambiguities. Our claim
is that a correct interpretation requires a formalism simi-
lar to distribution theory in functional analysis. To this end
we concretely construct a locally convex space of test string
states together with the dual space of functionals. We show
that the above suspicious expressions can be identified with
well defined elements of the dual
Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date
No full textFrancesca Cinti,* Simona Moffa,* Flavia Impronta,* Chiara MA Cefalo, Vinsin A Sun, Gian Pio Sorice, Teresa Mezza, Andrea Giaccari Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy *These authors contributed equally to this work Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an insulin-independent mechanism (glycosuria), they reduce glucose toxicity and improve insulin sensitivity and β-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP). This review focuses on ertugliflozin, a new, highly selective, and reversible SGLT2 inhibitor. Clinical trials published to date show that ertugliflozin, both as a monotherapy and as an add-on to oral antidiabetic agents, is safe and effective in reducing glycosylated hemoglobin (HbA1c), body weight, and BP in T2DM patients. Keywords: antidiabetic drugs, glycosylated hemoglobin, glycemic control, sodium-glucose cotransporter 2 inhibitors, precision medicine, type 1 diabetes mellitus, type 2 diabetes mellitus, weight reduction 
Tuning the properties of graphene oxide by chemical functionalization
No full textGraphene oxide (GO) has attracted rising interest since the discovery of the wet chemical route to graphene. GO is a non-stoichiometric, bi-dimensional carbon nanomaterial composed of a graphitic sheet decorated with various oxygen functional groups (OFGs). It is easily produced in large quantities and of good quality by wet-chemical oxidation and exfoliation of bulk graphite. Amongst the most, Hummers’ method is the most widely employed synthetic approach. The GO produced by these means is rich in OFGs such as islands of epoxides and hydroxyls in the basal plane and carbonyls, phenols, and carboxyl-groups on the edges and in the defects1. The coexistence of these groups makes GO prone to chemical functionalization through a plethora of synthetic pathways and to a wide range of electrostatic interactions. Furthermore, the presence of graphitic domains enables non-covalent functionalization through dispersive interactions such as π- π stacking. Additionally, GO and GO-based materials can be reduced by both electrochemical and chemical means to restore the π-delocalized network obtaining a reduced graphene oxide (rGO) with similar properties to pristine graphene. Therefore, due to its quivering chemistry, graphene oxide can be regarded as a perfect starting point for the design of graphene-based functional materials2.
This work aims to obtain graphene-based materials e.g. carboxyl-rich GO (GO-COOH) and reduced graphene oxide through different reaction approaches on previously synthesized GO. Respectively, these functionalized materials are obtained by exploiting O-acylation with succinic anhydride and reduction reaction with ascorbic acid and sodium ascorbate3. Furthermore, it will be explored the electrochemical reduction and concurrent deposition of GO and GO-based nanomaterials on different substrates. The materials obtained are characterized, step-by-step, by spectroscopy means e.g. XPS, Raman, and UV-Vis spectroscopies.
References
(1) Halbig C. A., Mukherjee B., Eigler S., Garaj S. J. Am. Chem. Soc., 2024, 146, 7431-7437.
(2) Guo S., Garaj S., Bianco A., Ménard-Moyon C. Nat. Rev. Phys., 2022, 4, 247-262.
(3) Amato F., Motta A., Giaccari L., Di Pasquale R., Scaramuzzo F. A., Zanoni R., Marrani A. G. Nanoscale Adv., 2023, 5, 893-906
Analytic solutions for Dp branes in SFT
No full textThis is the follow-up of a previous paper [JHEP 08 (2011) 158] of ours, where we calculated the energy of a proposed analytic lump solution in SFT representing a D24-brane. Here we propose a similar analytic solution for a Dp-brane, for any p, and compute its energy
The energy of the analytic lump solution in SFT
No full textAbstract: In a previous paper a method was proposed to find exact analytic solutions
of open string field theory describing lower dimensional lumps, by incorporating in string
field theory an exact renormalization group flow generated by a relevant operator in a
worldsheet CFT. In this paper we compute the energy of one such solution, which is
expected to represent a D24 brane. We show, both numerically and analytically, that its value corresponds to the theoretically expected on
Metformin benefits: Another example for alternative energy substrate mechanism?
No full textSince the UK Prospective Diabetes Study (UKPDS), metformin has been considered the first-line medication for patients with newly diagnosed type 2 diabetes. Though direct evidence from specific trials is still lacking, several studies have suggested that metformin may protect from diabetes-and nondiabetes-related comorbidities, including cardiovascular, renal, neurological, and neoplastic diseases. In the past few decades, several mechanisms of action have been proposed to explain metformin’s protective effects, none being final. It is certain, however, that metformin increases lactate production, concentration, and, possibly, oxidation. Once considered a mere waste product of exercising skeletal muscle or anaerobiosis, lactate is now known to act as a major energy shuttle, redistributed from production sites to where it is needed. Through the direct uptake and oxidation of lactate produced elsewhere, all end organs can be rapidly supplied with fundamental energy, skipping glycolysis and its possible byproducts. Increased lactate production (and consequent oxidation) could therefore be considered a positive mechanism of action of metformin, except when, under specific circumstances, metformin and lactate become excessive, increasing the risk of lactic acidosis. We are proposing that, rather than considering metformin-induced lactate production as dangerous, it could be considered a mechanism through which metformin exerts its possible protective effect on the heart, kidneys, and brain and, to some extent, its antineoplastic action
Le liquidazioni societarie tra norme giuridiche e principi contabili: lo scenario internazionale
No full textIl presente lavoro si sofferma sui comportamenti contabili delle imprese in liquidazione proponendo uno studio comparato tra Paesi civil law e Paesi common law. In particolare, l’articolo rappresenta una rassegna delle pratiche contabili applicate a livello internazionale (Europa continentale e contesto Anglo-sassone), in materia di liquidazione. Specifica attenzione è rivolta alle basi valutative adottabili nella redazione dell’informazione contabile nelle liquidazioni aziendali, considerando anche i possibili trattamenti contabili di riferimento per l’informazione di bilancio delle società IAS-compliant
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