44 research outputs found
The influence of glyoxalase 1 gene polymorphism on its expression at different stages of breast cancer in Egyptian women
No full textCrystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate
No full textIn the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°. The pyridone and benzothiazyl rings are linked by the intramolecular hydrogen bond N—Hamine...Nthiazole. The DMF O atom accepts two classical hydrogen bonds. The molecules are linked by hydrogen bonds and an S...O contact to form layers parallel to the bc plane
Crystal structure of 2-(benzo[d]thia-zol-2-yl)-3,3-bis-(ethyl-sulfan-yl)acrylo-nitrile
No full textIn the title compound, C14H14N2S3, the double-bond system of the acrylo-nitrile moiety is significantly non-planar, with absolute cis torsion angles of 13.9 (2) and 15.1 (2)°. The ring system and the double bond system subtend an inter-planar angle of 11.16 (4)°. The wide angle C-C(CN)=C of 129.40 (12)° may be associated with a balance between planarity and avoidance of a very short S⋯S contact
Reliability and Performance Optimization of Multi-Subsystem Systems Using Copula-Based Repair
No full textThis paper proposes a system made up of four subsystems connected in sequence. The first and third subsystems each have one unit, the second has two, and the fourth has three. Every subsystem operates in parallel and is governed by the K-Out-of-n:G rule. Nonetheless, each subsystem needs at least one operational unit in order for the system to work. While a unit’s failure has an exponential distribution, repair is simulated using a general distribution and a distribution from the Gumbel–Hougaard family of copula. This study’s primary objective is to assess and contrast the system performance while our system is running under these two different repair policies. The problem is solved by combining the supplementary variable technique with Laplace transforms. We use reliability metrics to assess system performance. The second objective of this study is to present a reduction approach plan aimed at improving the overall reliability metrics of our system
Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management
No full textSameh Saber,1 Rasha Abdelhady,2 Mai A Elhemely,3,4 Elsayed A Elmorsy,5 Rabab S Hamad,6 Mustafa Ahmed Abdel-Reheim,4,7 Attalla F El-kott,8 Mohammed A AlShehri,8 Kareem Morsy,8 Sally Negm,9 Ahmed Y Kira10 1Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt; 2Pharmacology and Toxicology Department, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt; 3School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M20 4BX, UK; 4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62521, Egypt; 5Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah, 51452, Saudi Arabia; 6Biological Sciences Department, College of Science, King Faisal University, Al Ahsa, 31982, Saudi Arabia; 7Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia; 8Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; 9Department of Life Sciences, College of Science and Art Mahyel Aseer, King Khalid University, Abha, 62529, Saudi Arabia; 10Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, EgyptCorrespondence: Mustafa Ahmed Abdel-Reheim; Ahmed Y Kira, Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt, Tel +2 1026462867, Fax +2 502770140, Email [email protected]; [email protected]: Chronic wounds in diabetic patients experience significant clinical challenges due to compromised healing processes. Hypoxia-inducible factor-1 alpha (HIF-1α) is a critical regulator in the cellular response to hypoxia, enhancing angiogenesis and tissue restoration. Nevertheless, the cellular response to the developed chronic hypoxia within diabetes is impaired, likely due to the destabilization of HIF-1α via degradation by prolyl hydroxylase domain (PHD) enzymes. Researchers have extensively explored HIF-1α activation as a potential pathway for diabetic wound management, focusing mainly on deferoxamine (DFO) as a potent agent to stabilize HIF-1α. This review provides an update of the other recent pharmacological agents managing HIF-1α activation, including novel PHD inhibitors (roxadustat and daprodustat) and Von Hippel‐Lindau protein (VHL) antagonists, which could be potential alternatives for the local treatment of diabetic wounds. Furthermore, it highlights how localized delivery via advanced nanostructures can enhance the efficacy of these novel therapies. Importantly, by addressing these points, the current review can offer a promising area for research. Given that, these novel drugs have minimal applications in diabetic wound healing, particularly in the context of local application through nanomaterials. This gap presents an exciting opportunity for further investigation, as combining these drugs with localized nanotechnology could avoid undesired systemic side effects and sustain drug release within wound site, offering a transformative platform for diabetes wound treatment. Keywords: nanomedicine, localized delivery, diabetic wound healing, novel prolyl hydroxylase inhibitor
Attractiveness of Spodoptera frugiperda and Agrotis ipsilon Moths to Different Essential Oils Using Y-tube
No full textThe present study was conducted to determine the attractiveness of female and male moths of fall armyworms (FAW), Spodoptera frugiperda(Smith), and black cutworms (BCW), Agrotis ipsilon (Hufnagel). A Y-tube olfactometer was used in laboratory studies when given a choice between control (distilled water) and essential oils. Rearing each of the fall armyworm and black cutworm for several generations in the laboratory Larvae were fed on castor bean leaves for more than 15 generations at a temperature of 26 ± 1°C and a relative humidity of 65± 5% to obtain a sensitive strain until reaching the pupae stage and the exit of the moths. Then the 15 male moths were separated from the 15 female moths. 50µ L / of each oil was placed on a filter paper, and similarly distilled water was used in the control treatment. The results showed Rosemary was highly attractive, with 66.6% for female moths, Lemongrass, Eucalyptus (Kafur), and Thyme (73.3%) for male moths, while Marjoram and a mixture of oils were more repellent for male moths of S. frugiperda. Geranium oil (60%) was recorded as attractive for female A. ipsilon moths; Chamomile oil attracted 80% of BCW male moths. On the other hand, Basil and Lemongrass (66.6%) were found to be repellent to BCW male moths. Therefore, this study can be used in the field to attract moths' females only inside the pheromone trap and also increase the rate of moths' male attraction. These results are considered effective within the framework of integrated pest management, where eco-friendly oils can be used at a simple and inexpensive rate in the field to reduce the damage caused by the targeted pests during integrated pest management
Promising photocatalytic and antimicrobial activity of novel capsaicin coated cobalt ferrite nanocatalyst
No full textAbstract In this study, CoFe2O4 nanoparticles were prepared by the co-precipitation method then surface modified with Capsaicin (Capsicum annuum ssp.). The virgin CoFe2O4 NPs and Capsaicin-coated CoFe2O4 NPs (CPCF NPs) were characterized by XRD, FTIR, SEM, and TEM. The antimicrobial potential and photocatalytic degradation efficiencies of the prepared samples via Fuchsine basic (FB) were investigated. The results revealed that CoFe2O4 NPs have spherical shapes and their diameter varied from 18.0 to 30.0 nm with an average particle size of 25.0 nm. Antimicrobial activity was tested on Gram-positive (S. aureusATCC 52923) and Gram-negative (E. coli ATCC 52922) by disk diffusion and broth dilution methods to determine the zone of inhibition (ZOI) and minimum inhibitory concentration (MIC), respectively. UV-assisted photocatalytic degradation of FB was examined. Various parameters affecting the photocatalytic efficiency such as pH, initial concentration of FB, and dose of nanocatalyst were studied. The in-vitro ZOI and MIC results verified that CPCF NPs were more active upon Gram-Positive S. aureus ATCC 52923 (23.0 mm ZOI and 0.625 μg/ml MIC) than Gram-Negative E. coli ATCC 52922 (17.0 mm ZOI and 1.250 μg/ml MIC). Results obtained from the photocatalytic activity indicated that the maximum FB removal achieving 94.6% in equilibrium was observed using 20.0 mg of CPCF NPS at pH 9.0. The synthesized CPCF NPs were effective in the removal of FB and also as potent antimicrobial agent against both Gram-positive and Gram-negative bacteria with potential medical and environmental applications
Comparison of Desired-Genetic-Gain Selection Indices in Late Generations as an Insight on Superior-Family Formation in Bread Wheat (Triticum aestivum L.)
No full textWheat is one of the most important sources of food worldwide. A selection index helps in making selection decisions and permits the exploitation of information on correlated traits to improve yields. Two cycles of pedigree selection based on the desired-genetic-gain selection index were imposed to identify the best index to isolate promising lines. The base population was composed of 120 families of bread wheat in the F6 generation. Eight combinations were constructed from six traits, i.e., days to heading (DH), number of spikes/plant (NS/P), grain yield/plant (GY/P), number of grains/spike (NG/S), mean spike weight (MSW) and mean grain weight (GW). The narrow-sense heritability of NS/P, NG/S, MSW and GW increased from cycle 1 to cycle 2, revealing an increase in the observed gain and homogeneity of the selected families for these traits from cycle to cycle. After the second cycle, the observed gain in GY/P ranged from 9.5 to 23.75% of the mid-parent. The best index for improving GY/P was index 2 (composed of GY/P, NS/P, NG/S, MSW and GW). The indices involving DH were inferior for improving GY/P. The desired-genetic-gain index was efficient in simultaneously improving several involved traits and was a good method to preserve genetic variability. Furthermore, six superior promising families were identified
Antimicrobial resistance profiles and virulence genotyping of Salmonella enterica serovars recovered from broiler chickens and chicken carcasses in Egypt
No full textAbstract Background This study aimed to survey the prevalence, antimicrobial resistance, and virulence-associated genes of Salmonella enterica recovered from broiler chickens and retail shops at El-Sharkia Province in Egypt. Salmonella virulence factors were determined using the polymerase chain reaction assays targeting the invA, csgD, hilC, bcfC, stn, avrA, mgtC, ompF, sopE1 and pefA genes. Results One hundred tweenty out of 420- samples from broiler chickens’ cloacal swabs, farm environmental samples, and freshly dressed whole chicken carcasses were positive Salmonella species. The isolates were serotyped as S. Enteritidis as the most dominant serotypes. Interestingly, none of the isolates were resistant to imipenem. The multidrug resistance was determined in 76.7% of the isolates with multidrug antibiotic resistance index of 0.2–0.6. Eight virulence genes (invA, csgD, hilC, stn, bcfC, mgtC, avrA, and ompf) were characterized among 120 S. enterica isolates with variable frequencies, while sopE1and pefA genes that were completely absent in all isolates. Based on the combination of presence and absence of virulence genes, the most common genetic profile (P7, 30%) was invA and csgD genes. Conclusion S. Enteritidis and S. Typhimurium were the most common identified serotypes in the examined sources. Circulation of such strains in broiler farms required introducing special biosecurity and biocontrol measures for control of Salmonella. Such measures might limit the adverse effects of antibiotics and ensure the safety of the environment and animal-derived food
Biliary fistula and late recurrence of liver hydatid cyst: Role of cysto-biliary communication: A prospective multicenter study
No full textBackground: Hydatid cyst disease (HCD) is common in certain locations. Surgery is associated with postoperative biliary fistula (POBF) and recurrence. The primary aim of this study was to identify whether occult cysto-biliary communication (CBC) can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase (ALP) levels in predicting POBF and recurrent HCD. Aim: To identify whether occult CBC can predict recurrent HCD. The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD. Methods: From September 2010 to September 2016, a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty. Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence. Results: There was a highly statistically significant association (P ≤ 0.001) between cystic fluid biochemical indices and the development of biliary complications (of 16 patients with POBF, 15 patients had high cyst fluid bilirubin and ALP levels), where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications. There was a highly statistically significant association (P ≤ 0.001) between biliary complications, biochemical indices, and the occurrence of recurrent HCD (of 30 patients with recurrent HCD, 15 patients had high cyst fluid bilirubin and ALP; all 16 patients who had POBF later developed recurrent HCD), where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts, respectively. Conclusion: Occult CBC can predict recurrent HCD. Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD
