928 research outputs found
A Study on Swetha Kuttam
Full text linkAIM AND OBJECTIVES:
AIM :
About 20 to 30% problems in human being pertain to dermatology, lot of interest has been developed in this field. Hence this study was carried out with an intention to study the “Swethakuttam” in various aspects with modern comparison and to formulate an apt treatment that would be given to the patient through Siddha Medicine.
OBJECTIVES:
This Scientific work on Swethakuttam was carried out to assess:
1. The incidence of this disease with age, gender, occupation, social, status diet, seasonal variation.
2. To collect the review of the disease dealing with definition, etiology, classification, signs and symptoms, prognosis, treatment and diet for Swethakuttam.
3. To correlate the signs and symptoms of Swethakuttam with that of modern science.
4. To expose siddha diagnostic principles.
5. To find out the quality safety and efficacy of the trail drug by doing
- Chemical Analysis
- Acute and sub acute toxicity Studies
- Pharmacological Studies
6. To find out the side effect or adverse reactions if any,
7. To Evaluate the Clinical efficacy of trail drugs.
MATERIALS AND METHODS:
The clinical study of Swatha Kuttam was carried out in post graduate department of Maruthuvam, Govt. Siddha Medical College, attached to Arignar Anna Hospital, Arumbakkam, Chennai – 600 106.
Selection of Cases:
The population consists of all patients with Swatha Kuttam (completely depigmented or hypopigmented patches without any structural change in the skin) satisfying the inclusion and exclusion criteria mentioned below.
Sample Size:
The trial size will be 40 patients. (Both Male and Female).
Data Collections:
Literary evidence collected from various
• Siddha Literature.
• Books on Modern medicines.
• Medical Journals.
• Internet.
Inclusion Criteria:
1. Age between 10 to 55 years,
2. Willing to give specimen of blood for investigation when required,
3. Willing to attend OPD once in 15 days for 3 months,
4. Hypoopigmental patches,
5. Patient having white or pink coloured patches.
Exclusion Criteria:
1. Patients of Jaundice,
2. Hypopigmented patches of leprosy and burns,
3. Connective tissue disorders,
4. Heart ailments are not eligible for this trial,
5. Fungal infection,
6. Worm infestation.
SUMMARY:
Swetha kuttam has been chosen for the dissertation work by the author.
Various literatures dealing with swetha kuttam have been collected from siddha
and modern text books.
40 patients of both sexes, various adult age groups satisfying the inclusion and
exclusion criteria were selected. All necessary investigation was done for them and photographs of the lesions were taken.
A day before starting the trial treatment, patients are given for neutralizing the mukkutram by purgation Agasthiyar kuzhambu 100mg early morning with hot water. All the patients were treated with trial medicines which are,
1. Puvarasampattai kudineer choornam,
2. Nuna thylam.
The result obtained from the studies are summarized below Male 26 (65%), were affected more than female 14 (35%). The cases were noted in the age group ranging from 10-55 yrs.
Middle classes 52.5% and lower 37.5% were more affected than upper classes 10%.
High incidence of swetha kuttam are found in neithal thinai 72.5% and muthuvenil kaalam 47.5%.
On examination of uyir thathukkal the following were deranged in more number of cases.
In vatham : Viyanan 25%, and koorman were affected 12.5%.
In pitham : Prasagam 100%, ranjagam 100%, alosagam 12. 5% were affected.
In kapham : Avalambagam 5%, santhigam 37.5% was affected.
In udal kattugal: Saaram 100%, seneer 100%, and enbu 25% were affected.
In envagai thervu: Naa 12.5%, niram 100%, vizhi 12.5%, malam 12.5% were affected.
Among the 40 patients responding to the trial medicines, 33 patients showed improvement which has been noted as appearance of chormous repigmented spots in affected areas. The rest of 7 patients had slight repigmentation.
Among 3 patients 2 of them had improvement in the colour change of the hair from gray or white to normal colour of the hair.
The chemical studies of the trial drugs possess, Iron, Zinc, Sugar Calcium, Potassium, Chloride.
The drug is also subjected to pharmacological and toxicological tests in rats as models. The results revealed that the drug had very effective results. There were no signs of toxicities that could be judged by the absence of undesirable clinical manifestations.
The bio-statistical report of the clinical trial shows significant result.
CONCLUSION:
Swetha kuttam may occur due to various causes and it leads to mental stress and strain.hence,it is one of the cause of psychosomatic disorder. when the trial drug Puvarasampattai kudineer choornam (int), with Nuna thylum (ext) were administered to the swetha kuttam patients, it showed improvement in varying degrees in all the cases.
• In Swetha Kuttam Pitha Kutram is affected. The affected kuttram is neutralized by thuvarppu suvai. Thereby the trial medicine puvarasampattai kudinner choornam having the thuvarppu suvai acts on Ethirurai to cure the discease.
• In Chemical Analysis the trial medicine contain Iron, it is very essential to induce erythropoiesis.
• From the pharmacological study puvarasampattai kudineer choornam increase the haemoglobin level.
• The puvarasampattai kudineer choornam does not produce any toxicity in preclinically. so it is non-toxic and safe drug for swetha kuttam.
• No adverse effects were noticed during treatment period. The ingredient of puvarasampattai kudineer choornam of plant easily available and harmless
to human being.
From this clinical studies, I conclude that the trial medicines which gives a 60% of improvement within minimum of 45 days to maximum of 90 days of treatment. further continuation of this medications for prolonged period of time may give complete cure in swetha kuttam
Cyber Security Intelligence
No full textGovernments, military, organizations, financial institutions, universities and other businesses collected, process and store a large amount of confidential information and data on computers and transmit that data over networks to other computers. With the continuous rapid growth of volume and sophistication of cyberattacks, quick attempts are required to secure sensitive business and personal information, as well as to protect national security. The paper details about the nature of cyberspace and shows how the internet is unsecure to transmit the confidential and financial information. We demonstrate that hacking is now common and harmful for global economy and security and presented the various methods of cyber attacks in India and worldwide. M. Swetha | L. Prabha | S. Rajadharani "Cyber Security Intelligence" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29261.pd
Shelf Life Of Probiotic Fermented Milk In Different Packaging Materials
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady-state free precession in spontaneous human osteoarthritis
No full textThis dataset contains key analysis and plotting scripts, data, and sample images. Measurement of T1ρ dispersion with compressed sensing and magnetization prepared radial balanced steady-state free precession in spontaneous human osteoarthritis Magnetic Resonance in Medicine Journal | DOI: 10.1002/mrm.30206 § Swetha Pala(1), § Antti Paajanen(1), Aapo Ristaniemi(1), Ervin Nippolainen(1), Isaac O. Afara(1), Olli Nykänen (1), Mikko J. Nissi (1*) 1Department of Technical Physics, University of Eastern Finland §Shared authorship *Corresponding author Mikko J. Nissi Department of Technical Physics University of Eastern Finland, Kuopio Finland POB 1627 70211 Kuopio [email protected] +358-50-5955517 Keywords: Quantitative MRI, T1ρ relaxation, T1ρ dispersion, Compressed-sensing, radial acquisition. Included folders and files are: - Article_figures: all figures published in the manuscript (.eps format) - Data: MRI data files from 27 human cadaver samples with subfolders and files: - Human samples data: raw data files, along with generic analysis ROIs, zone divison inside specific samples folder, and within the parameter related data folder there are smaple specific analysis ROIs, computed profiles per spin lock amplitude. - CS reconstructed data files: - DataTables_used_for_analysis: Contains data tables per AF and reference data used for data analysis - Scripts: Matlab functions used for data processing and T1ρ computation, aedes plugins, and data analysis with subfolders and files: - Aedes_plugins: Plugins for aedes (http://aedes.uef.fi) for calculation of profiles from ROI. - Data analysis: Key scripts used for analysis and plotting. - Common functions: Some common functions that are required by the scripts/plugins. - README.txt: this file describing the contents of the dataset. See more info in separate readme files included in sub-folders. (Swetha Pala, 02 July 2024
Transforming Euclidean Object files to Hyperbolic Data files
Full text linkUniversity of Minnesota M.S. thesis. June 2016. Major: Computer Science. Advisor: douglas dunham. 1 computer file (PDF); vii, 49 pages.The creation of repeating hyperbolic patterns has been of interest for more than 100 years. However, manual creation of these patterns was very tedious and time-consuming. Escher created such patterns manually in 1950's. At that time, he had no access to computers. Later on, several researchers, tried to create these patterns automatically. For this purpose, they had written code in C. Programs for automatic creation of these patterns now exist in C++ and JAVA. These programs take parameters p and q to generate a regular tesselation p,q of hyperbolic plane. Here p represents a regular p-sided polygon and q specifies the number of them that meet at each vertex. These program generates repeating hyperbolic patterns from hyperbolic data files. However, there is no means to generate hyperbolic data files from Euclidean object files.Naidu, Swetha. (2016). Transforming Euclidean Object files to Hyperbolic Data files. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/191250
Impact of cell cycle dependent endocytosis of DNA-wrapped single-walled carbon nanotubes (DNA-SWCNTs) on the fate of neural progenitors
No full textNanomaterials have been employed as imaging agents and drug delivery vehicles for disease therapy across the medical field. Carbon nanotubes in particular are of the appropriate size and can be modified with functional groups to allow transport through the blood brain barrier (BBB) and aid in delivery of therapeutics to the central nervous system (CNS). In this study, the entry and lasting effects of nano-molar concentrations of (GT)20 DNA-wrapped single walled carbon nanotubes (SWCNT, roughly 1 nm dia, 100+ nm length) on C17.2 neural progenitor cells (NPCs) was examined. Though commonly used concentrations, often in the micro-molar range, have yielded evidence of cytotoxicity and reorganization of cellular sub structure, the use of nanomaterials have been shown to have promise in therapeutics in vitro and in vivo when size, concentration and functionalization are considered and optimized. Low picomolar concentrations of DNA-SWCNTs exposure have shown to augment cell division and differentiation of NPCs. While this discovery opens a gateway for nanomaterials-based therapies for neurogenesis, the mechanisms of cellular entry, long-term residence, and their effect on cell structure and fate are not well understood.Given that cellular fate process such as cell division and differentiation were affected by the presence of the nanomaterials, an investigation into the role of the cell cycle was initiated to understand the implications of these materials. Common drugs (lovastatin, thymidine and nocodazole) were used as cell cycle arrest agents to synchronize neural stem cells (NSCs) in phases (early G1, late G1/S and G2/M respectively) as discerned by flow cytometry, at rates (80%, 85% and 89% respectively) that rival previously documented levels of synchrony for stem cells. This ultimately induced phase-dependent normalized cellular organization on which further correlations could be assessed. The internalized SWCNTs were then visualized for localization and correlation with intracellular components using hyperspectral imaging via confocal micro-Raman spectroscopy. Imaging SWCNT uptake post-synchrony showed that cultures of majority late G1/S cells led to a 40% decrease in uptake, while cultures consisting primarily of early G1 and G2/M cells led to 40% and 390% increases in uptake, respectively. This suggests that the late G1 and early S phases are selective to uptake of materials, and G2/M phase is an avid acceptor of materials as it has a four-fold higher yield of internalized nanotubes per cell on average, when compared to control cells. This proves the dependency of uptake on the mitotic phase of the cell cycle.Subsequently, three main endocytic mechanisms were surveyed for their contributions to NT uptake and the dependency of endocytosis on the cell cycle: receptor mediated endocytosis (RME), macropinocytosis (MP), clathrin-independent endocytosis (CIE). Known inhibitors of endocytosis (hypertonic sucrose, amiloride and filipin) were used to gain individual control over established endocytic delivery machineries (of receptor mediated endocytosis, macro-pinocytosis and clathrin-independent endocytosis respectively) which resulted in an 87%, 61% and 67% decrease in uptake of SWNTs respectively, in comparison to the control. With reductions across the board in all mechanisms post-inhibition, the results showed that all three mechanisms contribute in some capacity to the uptake of DNA-wrapped SWCNT in C17.2 NPCs, with strong suggestions towards the substitution of one or more endocytic mechanisms in the absence of others.Finally, the connection between the endocytosis of SWCNTs and the induction of early differentiation in NPCs was examined. Pathway bioinformatics was performed using databases along with literature study to determine a functional gene set of key markers and pathways involved in the instigation of differentiation. Protein expression studies revealed that Notch1 and numb proteins are key players in C17.2 NSC differentiation. Similarly, doublecortin (DCX), NeuroD1 were determined to play varying roles in differentiation. MAP2 and GFAP expression gave insight into post treatment neuron and astrocyte development. These studies will lead to further insights into chronology of altered cellular dynamics and molecular-level investigation of the effect of SWCNTs on NPCs
Greedy routing and virtual coordinates for future networks
Full text linkAt the core of the Internet, routers are continuously struggling with
ever-growing routing and forwarding tables. Although hardware advances
do accommodate such a growth, we anticipate new requirements e.g. in
data-oriented networking where each content piece has to be referenced
instead of hosts, such that current approaches relying on global
information will not be viable anymore, no matter the hardware
progress. In this thesis, we investigate greedy routing methods that
can achieve similar routing performance as today but use much less
resources and which rely on local information only. To this end, we
add specially crafted name spaces to the network in which virtual
coordinates represent the addressable entities. Our scheme enables participating
routers to make forwarding decisions using only neighbourhood information,
as the overarching pseudo-geometric name space structure already
organizes and incorporates "vicinity" at a global level.
A first challenge to the application of greedy routing on virtual
coordinates to future networks is that of "routing dead-ends"
that are local minima due to the difficulty of consistent coordinates
attribution. In this context, we propose a routing recovery scheme
based on a multi-resolution embedding of the network in low-dimensional Euclidean spaces.
The recovery is performed by routing greedily on a blurrier view of the network. The
different network detail-levels are obtained though the embedding of
clustering-levels of the graph. When compared with
higher-dimensional embeddings of a given network, our method shows a
significant diminution of routing failures for similar header and
control-state sizes.
A second challenge to the application of virtual coordinates and
greedy routing to future networks is the support of
"customer-provider" as well as "peering" relationships between
participants, resulting in a differentiated services
environment. Although an application of greedy routing within such a
setting would combine two very common fields of today's networking
literature, such a scenario has, surprisingly, not been studied so
far. In this context we propose two approaches to address this scenario.
In a first approach we implement a path-vector protocol similar to
that of BGP on top of a greedy embedding of the network. This allows
each node to build a spatial map associated with each of its
neighbours indicating the accessible regions. Routing is then
performed through the use of a decision-tree classifier taking the
destination coordinates as input. When applied on a real-world dataset
(the CAIDA 2004 AS graph) we demonstrate an up to 40% compression ratio of
the routing control information at the network's core as well as a computationally efficient
decision process comparable to methods such as binary trees and tries.
In a second approach, we take inspiration from consensus-finding in social
sciences and transform the three-dimensional distance data structure
(where the third dimension encodes the service differentiation) into a
two-dimensional matrix on which classical embedding tools can be used.
This transformation is achieved by agreeing on a set of
constraints on the inter-node distances guaranteeing an
administratively-correct greedy routing. The computed distances are
also enhanced to encode multipath support. We demonstrate a good
greedy routing performance as well as an above 90% satisfaction of multipath constraints
when relying on the non-embedded obtained distances on synthetic datasets.
As various embeddings of the consensus distances do not fully exploit their multipath potential, the use of compression techniques such as transform coding to
approximate the obtained distance allows for better routing performances
Studies on Correlation between Protein Solubility and Extraction of Saponins from Karanja Seed
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Galactooligosaccharides: By transgalactosylation of lactose using intracellular β-galactosidase from potent probiotic
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
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