1,101 research outputs found
P35 Spatial proteomics and metabolomics investigations in head & neck cancers
No full textGendreizig S, Neumann JM, Loganathan L, et al. P35 Spatial proteomics and metabolomics investigations in head & neck cancers. Oral Oncology. 2022;134: 106164
Weak convergence of fixed point iterations in -metric spaces
Full text linkThis paper extends the notion of weak convergence in metric spaces to the case of S-metric spaces. Moreover, some results on the weak convergence of fixed point iterations of Banach's, Kannan's, Chatterjee's, Reich's, Hardy and Roger's types of contractions on S-metric spaces are obtained. In addition, an example is presented to demonstrate our primary result
Evaluating off-peak pricing strategies in public transportation with an activity-based approach
No full textExpression pattern of VEGFR-2 (Quek1) during quail development
No full textThe growth and maintenance of the blood and lymphatic vascular systems is to a large extent controlled by members of the vascular endothelial growth factor (VEGF) family via the tyrosine kinase receptors (VEGFRs) expressed in angioblastic cells. Here, we analyzed the Quek1 (VEGFR-2) expression pattern by whole mount in situ hybridization during quail development. During early embryogenesis, Quek1 expression was detected at the caudal end of the blastoderm and primitive streak and in the head paraxial mesoderm. In somites, expression was observed from HH-stage 9 onwards in the dorsolateral region of both the forming and recently formed somites. During somite maturation, expression persists in the lateral portion of the somitic compartments, the dermomyotome and the sclerotome. Additionally, a second expression domain in the maturing somite was observed in the medial part of the sclerotome adjacent to the neural tube. This expression domain extended medially and dorsally and surrounded the neural tube during later stages. In the notochord, expression was observed from HH-stage 23 onwards. In the limb bud, expression was initiated in the mesenchyme at HH-stage 17. During organogenesis, expression was detected in the pharyngeal arches and in the anlagen of the esophagus, trachea, stomach, lungs, liver, heart and gut. Expression was also seen in feather buds from day 7 onwards. Our results confirm the angiogenic potential of the mesoderm and suggest that VEGFR-2 expressing cells represent multiple pools of mesodermal precursors of the hematopoietic and angiopoietic lineages
Evaluating off-peak pricing strategies in public transportation using an activity-based approach
No full textPublic transportation authorities across the world are implementing various peak and off-peak pricing strategies to manage travel demand and improve the overall system performance. In this study, an activity-based demand framework is used to evaluate two off-peak pricing policies currently in use in Singapore. These policies consist of a free pre-peak travel on MRT and an off-peak discount for an integrated transit (public buses and MRT). Smart card data collected before and after the implementation of the first policy was used to calibrate the behavioral models involved, in order to properly capture travelers' preferences and choices. To evaluate both pricing strategies, a comprehensive set of key performance indicators was considered, including the changes in peak ridership, average trip fare, operator's revenue, the number of public transportation trips and mode share. The results indicate that off-peak discount pricing strategies are a viable policy option for spreading demand peaks, and that they are more effective in the afternoon peak. This study also demonstrates the capabilities and the advantages of an agent-based modeling platform SimMobility as a tool for policy analysis
sj-docx-3-dhj-10.1177_20552076231205733 - Supplemental material for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial
No full textSupplemental material, sj-docx-3-dhj-10.1177_20552076231205733 for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial by Antonia Thodis, Thu-Ha Dang, Josefine Antoniades and
Andrew S. Gilbert, Tuan Nguyen, Danijela Hlis, Mary Gurgone, Briony Dow, Claudia Cooper, Lily-Dongxia Xiao, Nilmini Wickramasinghe, Nalika Ulapane, Mathew Varghese, Santosh Loganathan, Joanne Enticott, Duncan Mortimer, Bianca Brijnath in DIGITAL HEALTH</p
Contamination Profile and Temporal Trend of POPs in Antarctic Biota
No full textThe continent of Antarctica is a cold desert surrounded by the Southern Ocean; its northern boundary is the Antarctic circumpolar current (ACC), commonly referred to as the polar front. The ACC is formed where cold seawaters sink beneath the northerly warmer waters. It acts as a biological barrier: organisms are not able to cross it because of the deeply different physicochemical properties of seawaters. Thus, only large animals can cross it (cetaceans, seabirds). The atmosphere over the southern hemisphere shows also a polar front where the Ferrell Cell (mid-latitude air circulation) meets the polar cell: in the former, the air flows toward the poles and eastward near the surface and equatorially and westerly at higher altitudes. At the front, air rises and travels towards the pole, where it sinks forming the polar highs. The Antarctic continent and the Southern Ocean are almost isolated from the other oceans and air masses and thus the turnover is very low. These geographical and air/ocean circulation features make this region of the planet difficult to be reached by persistent organic pollutants (POPs). At the same time, other characteristics of the continent and of the Southern Ocean affect the sinking and bioaccumulation of POPs in abiotic and biotic compartments of Antarctic ecosystems. © 2012 by Taylor & Francis Group, LLC
sj-doc-2-dhj-10.1177_20552076231205733 - Supplemental material for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial
No full textSupplemental material, sj-doc-2-dhj-10.1177_20552076231205733 for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial by Antonia Thodis, Thu-Ha Dang, Josefine Antoniades and
Andrew S. Gilbert, Tuan Nguyen, Danijela Hlis, Mary Gurgone, Briony Dow, Claudia Cooper, Lily-Dongxia Xiao, Nilmini Wickramasinghe, Nalika Ulapane, Mathew Varghese, Santosh Loganathan, Joanne Enticott, Duncan Mortimer, Bianca Brijnath in DIGITAL HEALTH</p
sj-doc-1-dhj-10.1177_20552076231205733 - Supplemental material for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial
No full textSupplemental material, sj-doc-1-dhj-10.1177_20552076231205733 for Improving the lives of ethnically diverse family carers and people living with dementia using digital media resources – Protocol for the Draw-Care randomised controlled trial by Antonia Thodis, Thu-Ha Dang, Josefine Antoniades and
Andrew S. Gilbert, Tuan Nguyen, Danijela Hlis, Mary Gurgone, Briony Dow, Claudia Cooper, Lily-Dongxia Xiao, Nilmini Wickramasinghe, Nalika Ulapane, Mathew Varghese, Santosh Loganathan, Joanne Enticott, Duncan Mortimer, Bianca Brijnath in DIGITAL HEALTH</p
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model
Full text linkOvarian cancer is the leading cause of cancer related deaths in women. Genetic alterations including overexpression of EGFR play a crucial role in ovarian carcinogenesis. Here we evaluated the effect of phenethyl isothiocyanate (PEITC) in ovarian tumor cells in vitro and in vivo. Oral administration of 12 μmol PEITC resulted in drastically suppressing ovarian tumor growth in a preclinical mouse model. Our in vitro studies demonstrated that PEITC suppress the growth of SKOV-3, OVCAR-3 and TOV-21G human ovarian cancer cells by inducing apoptosis in a concentration-dependent manner. Growth inhibitory effects of PEITC were mediated by inhibition of EGFR and AKT, which are known to be overexpressed in ovarian tumors. PEITC treatment caused significant down regulation of constitutive protein levels as well as phosphorylation of EGFR at Tyr1068 in various ovarian cancer cells. In addition, PEITC treatment drastically reduced the phosphorylation of AKT which is downstream to EGFR and disrupted mTOR signaling. PEITC treatment also inhibited the kinase activity of AKT as observed by the down regulation of p-GSK in OVCAR-3 and TOV-21G cells. AKT overexpression or TGF treatment blocked PEITC induced apoptosis in ovarian cancer cells. These results suggest that PEITC targets EGFR/AKT pathway in our model. In conclusion, our study suggests that PEITC could be used alone or in combination with other therapeutic agents to treat ovarian cancer. © 2012 Loganathan et al
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