1,721,013 research outputs found
Polarité cellulaire et morphogenèse / Cell polarity and morphogenesis
No full textSéminaire FSER organisé par André Le Bivic (IBDM, Marseille, France) et Daniel St Johnston (The Gurdon Institute, University of Cambridge, UK) du 25 juin au 30 juin 2018 Participants Jean-Paul Borg, Arnaud Echard, Nathan Goehring, André Le Bivic, Pierre-François Lenne, Ian G. Macara, Jean-Léon Maître, Sophie Martin, Fernando Martín-Belmonte, Mireille Montcouquiol, Edwin Munro, Caren Norden, Ewa Paluch, Rytis Prekeris, Josana Rodriguez, Bénédicte Sanson, Daniel St Johnston, Ulrich Tepass, John..
Cytocinèse, l’étape finale de la division cellulaire / Cytokinesis, the final step of cell division
No full textSéminaire FSER organisé par Arnaud Echard (Institut Pasteur, Paris, France) du 2 au 7 avril 2018 Participants Renata Basto, William Bement, Julie C. Canman, Jeremy Carlton, Arnaud Echard, Ulrike Eggert, Christine Field, Daniel Gerlich, Mariagrazia Giansanti, Michael Glotzer, Gilles Hickson, Carsten Janke, Péter Lénárt, Juan Martin-Serrano, Juliette Mathieu, Thomas Müller-Reichert, Karen Oegema, Rytis Prekeris, Aurélien Roux, Anne Royou Et Héloïse Dufour (Cercle FSER) pour la matinée « Meeting..
Rabs, Rips, FIPs, and Endocytic Membrane Traffic
Get PDFRab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phagocytosis, and cytokinesis. Rab11 acts by forming mutually exclusive complexes with Rab11-family binding proteins, known as FIPs. Rab11-FIP complexes serve a role of �targeting complexes� by recruiting various membrane traffic factors to cellular membranes. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways
Apical protein transport and lumen morphogenesis in polarized epithelial cells
No full textSegregation of the apical and basolateral plasma membrane domains is the key distinguishing feature of epithelial cells. A series of interrelated cues and processes follow this primary polarization event, resulting in the morphogenesis of the mammalian epithelium. This review focuses on the role of the interactions between the extracellular matrix and neighbouring cells during the initiation and establishment of epithelial polarity, and the role that membrane transport and polarity complexes play in this process. An overview of the formation of the apical junctional complexes is given in relation to the generation of distinct membrane domains characterized by the asymmetric distribution of phosphoinositides and proteins. The mechanisms and machinery utilized by the trafficking pathways involved in the generation and maintenance of this apical-basolateral polarization are expounded, highlighting processes of apical-directed transport. Furthermore, the current proposed mechanisms for the organization of entire networks of cells into a structured, polarized three-dimensional structure are described, with an emphasis on the proposed mechanisms for the formation and expansion of the apical lumen.</jats:p
3D Time-Lapse Analysis of Rab11/FIP5 Complex: Spatiotemporal Dynamics During Apical Lumen Formation
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