1,277 research outputs found
The effect of pterygium surgery on contrast sensitivity and corneal topographic changes
No full textJoo Youn Oh, Won Ryang WeeDepartment of Ophthalmology, Seoul National University Hospital, Seoul, KoreaPurpose: To investigate the effect of pterygium surgery on corneal topography and contrast sensitivity.Patient and methods: The IRB approved this prospective, nonrandomized, self-controlled study. Computerized videokeratography (Orbscan II) was performed in 36 patients with primary pterygia, both before and 1 month after pterygium excision with limbal-conjunctival autografting. The topographic parameters were compared. Spatial contrast sensitivity testing was performed using VCTS 6500. Differences between preoperative and postoperative values were evaluated statistically.Results: The mean Sim K astigmatism and irregularity index, significantly decreased after pterygium surgery. The mean refractive power significantly increased after the operation. The “with-the-rule” astigmatism induced by pterygium became “against-the-rule” astigmatism after pterygium removal (P = 0.041). The contrast sensitivity of 6, 12, and 18 cycles per degree, significantly increased from 1.55 ± 0.28, 0.97 ± 0.47, and 0.29 ± 0.16 to 1.72 ± 0.18, 1.21 ± 0.44, and 0.65 ± 0.48, respectively (P = 0.007, <0.001, <0.001, respectively).Conclusions: Pterygium surgery significantly reduces corneal topographic astigmatism and improves contrast sensitivity.Keywords: corneal topography, visual acuit
Infliximab for progressive peripheral ulcerative keratitis in a patient with juvenile rheumatoid arthritis
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A case of corneal endothelial deterioration associated with retained Descemet`s membrane after penetrating keratoplasty
No full textIde T, 2008, OPHTHAL SURG LAS IM, V39, P422VENGAYIL S, 2008, CONT LENS ANTERIOR E, V31, P161Patel SV, 2005, AM J OPHTHALMOL, V139, P311, DOI 10.1016/j.ajo.2004.09.045Sinha R, 2003, BRIT J OPHTHALMOL, V87, P654Masket S, 1996, J CATARACT REFR SURG, V22, P139
Mooren Ulcer in a Child Wearing Orthokeratology Contact Lenses
No full textPurpose: To report a case of Mooren ulcer that developed in a pediatric patient wearing orthokeratology overnight contact lenses. Methods: Case report. Results: A 10-year-old boy was referred to our clinic because of progressive peripheral corneal ulcer in the right eye, despite the intensive use of fortified antibiotic eye drops. The patient had been using overnight orthokeratology lenses for 4 months before presentation of corneal ulcer. There was no other history of ocular or systemic trauma and disorders. Microbiological tests of the lesion were negative. Systemic evaluation showed no sign of rheumatologic disease. Under a diagnosis of Mooren ulcer, the patient was treated with topical and systemic corticosteroids. After four weeks of treatment, the patient's symptoms rapidly disappeared, and corneal ulcer was healed. The vision recovered to normal with the correction of with-the-rule astigmatism. Conclusions: Mooren ulcer can develop in pediatric patients wearing orthokeratology contact lenses. Given rapid progression of Mooren ulcer in a young population, early diagnosis and proper treatment are essential to prevent a devastating outcome.N
Effects of Mesenchymal Stem/Stromal Cells on Cultures of Corneal Epithelial Progenitor Cells With Ethanol Injury
No full textPURPOSE. Mesenchymal stem/stromal cells (MSCs) facilitate the regeneration of injured tissue. Our group has previously shown that human MSCs (hMSCs) or hMSC-derived factors suppress excessive inflammatory response in the cornea following chemical injury in vivo. We here investigated direct effects of hMSC-derived factors on cultures of chemically injured human corneal epithelial progenitor cells (hCEP), independent of systemic anti-inflammatory effects that hMSCs have been shown to have in vivo. METHODS. We injured hCEP by incubation in 20% ethanol for 30 seconds, and cultured the cells in fresh medium or in medium derived from cultures of human dermal fibroblasts (hFbs), hMSCs, or TNF-alpha-activated hMSCs. After 24 hours, we evaluated the survival, proliferation, and apoptosis of the cells. RESULTS. The hMSC-conditioned medium enhanced survival and proliferation and inhibited apoptosis of chemically injured hCEP. In addition, the conditioned medium accelerated the wound healing of corneal epithelium in tissue cultures of rabbit corneas following injury. The effects of the hMSC-conditioned medium were increased by preincubating hMSCs with TNF-alpha The increased effectiveness of the medium from the preactivated hMSCs was in part explained by increased concentration of the multifunctional protein stanniocalcin-1 that inhibits apoptosis and promotes survival of cells. CONCLUSIONS. Together, the data account for beneficial effects of hMSCs on tissue-endogenous stem cells involving hCEP, and provide a basis for using MSCs or MSC-derived factors to treat diseases of the cornea and other tissues.N
Subconjunctival and Intracorneal Bevacizumab Injection for Corneal Neovascularization in Lipid Keratopathy
No full textPurpose: The purpose of this study was to evaluate the efficacy and safety of subconjunctival and corneal intrastromal bevacizumab injections on corneal neovascularization in patients with lipid keratopathy. Methods: Three eyes of 3 patients with lipid keratopathy accompanied by corneal neovascularization received at least 2 subconjunctival and corneal intrastromal injections of bevacizumab (1.25 mg/0.05 mL, respectively) at 1-month intervals. Ophthalmic examinations, including visual acuity, tonometry; slit lamp biomicroscopy, and corneal topography, were performed before injection and every month thereafter. Results: All patients had marked regression of corneal neovascularization. Reduction in lipid deposition was noted in one patient. There were no adverse ocular or systemic events, except for a small intracorneal hemorrhage noted in one patient, which quickly and spontaneously cleared. Conclusion: Subconjunctival and intracorneal bevacizumab is a well-tolerated and effective method for obliterating corneal neovascularization in lipid keratopathy.Yu CQ, 2008, INVEST OPHTH VIS SCI, V49, P3870, DOI 10.1167/iovs.07-1418Carrasco MA, 2008, CORNEA, V27, P743Hurmeric V, 2008, CORNEA, V27, P357Papathanassiou M, 2008, AM J OPHTHALMOL, V145, P424, DOI 10.1016/j.ajo.2007.11.003Bahar I, 2008, CORNEA, V27, P142KIM SW, 2008, OPHTHALMOLOGY, V115, pE33Uy HS, 2008, CORNEA, V27, P70BAHAR I, 2008, CURR EYE RES, V33, P22Hosseini H, 2007, CLIN EXP OPHTHALMOL, V35, P745, DOI 10.1111/j.1442-9071.2007.01572.xBarros LFM, 2007, AN ACAD BRAS CIENC, V79, P389Manzano RPA, 2007, BRIT J OPHTHALMOL, V91, P804, DOI 10.1136/bjo.2006.107912Bock F, 2007, INVEST OPHTH VIS SCI, V48, P2545, DOI 10.1167/iovs.06-0570Wertheim MS, 2007, CORNEA, V26, P230Avery RL, 2006, OPHTHALMOLOGY, V113, P1695, DOI 10.1016/j.ophtha.2006.05.064AZAR DT, 2006, T AM OPHTHAL SOC, V104, P264MOSHFEGHI AA, 2006, OPHTHALMOLOGY, V113, pE1, DOI DOI 10.1016/J.OPHTHA.2006.05.070Loeffler KU, 2005, ARCH OPHTHALMOL-CHIC, V123, P1435Philipp W, 2000, INVEST OPHTH VIS SCI, V41, P2514Pillai CT, 2000, INVEST OPHTH VIS SCI, V41, P2148DAMATO RJ, 1994, P NATL ACAD SCI USA, V91, P4082MARSH RJ, 1988, BRIT J OPHTHALMOL, V72, P900LINDSTROM RL, 1986, NEW ENGL J MED, V315, P1MAYER W, 1967, ARCH OPHTHALMOL-CHIC, V77, P637LAVERAGE G, 1964, BR J OPHTHALMOL, V48, P416AINSLIE D, 1962, CLIN RADIOL, V13, P29
Interplay of imune cells in mooren ulcer
No full textPurpose:To report the histopathological findings of the cornea with fulminant Mooren ulcer, an idiopathic autoimmune keratitis.Methods:A 54-year-old woman was diagnosed with Mooren ulcer. Despite intensive immunosuppression, corneal perforation developed, and penetrating keratoplasty with a limbal tectonic graft was performed. The removed cornea was histopathologically evaluated for the phenotype of the cells infiltrating the lesion.Results:Hematoxylin-eosin staining showed massive infiltration of inflammatory cells in the anterior corneal stroma and epithelial hyperplasia in the adjacent conjunctiva. Further analysis with immunohistochemistry indicated that the cells infiltrating the lesion included a number of CD4(+) and CD8(+) T lymphocytes, CD19(+)CD45(+) B lymphocytes, and CD14(+)CD68(+) macrophages. There were a few neutrophils and no CD56(+) NK cells.Conclusions:Our findings suggest that multiple types of immune cells including T cells, B cells, and macrophages are involved in the pathogenesis of Mooren ulcer.N
Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome
No full textPurposeTo investigate tear film stability and secretion according to serum 25-hydroxyvitamin D3 [25(OH)D] levels in dry eye patients. MethodsIn this retrospective observational study, the medical charts of 92 patients who visited the Department of Ophthalmology at Hallym University Kangnam Sacred Heart Hospital from April to August 2015 were reviewed. Serum 25(OH)D levels were measured. Subjects were divided into three groups according to serum 25(OH)D levels: sufficient, inadequate or deficient group. Eye discomfort was measured by ocular surface disease index (OSDI). Tear break-up time (TBUT), fluorescein staining score and Schirmer's tear secretion test were measured. ResultsThe mean age was 53.3813.69years. Mean serum 25(OH)D level was 14.41 +/- 5.98ng/ml. Tear break-up time (TBUT) and tear secretion were positively correlated with serum 25(OH)D levels (r=0.389, p=0.001; and r=0.428, p<0.001, Pearson correlation test). Tear break-up time (TBUT) and tear secretion were shorter in the vitamin D-deficient group compared to the sufficient group (p=0.022 and p=0.004). Fluorescein staining scores and OSDI scores were not different between the three groups. ConclusionTear break-up time (TBUT) and secretion were correlated with serum vitamin D levels. Vitamin D status may be an important factor for dry eye syndrome.OAIID:RECH_ACHV_DSTSH_NO:T201701028RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A002852CITE_RATE:3.157FILENAME:Jin_et_al-2016-Acta_Ophthalmologica.pdfDEPT_NM:의학과EMAIL:[email protected]_YN:YFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/158f6b5a-1733-4571-b5ab-7e4de5e6b3c3/linkN
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