1,721,089 research outputs found
Natural frequencies and dampings identification using wavelet transform: application to real data
No full textThe wavelet transform is used as a time-frequency representation for system identification purposes. It is shown that wavelet analysis of the free response of a system allows the estimation of the natural frequencies and viscous damping ratios. The advantages of the wavelet transform in the analysis of the free decay of the system are underlined and a comparison with previous techniques is made. The accuracy of this method is confirmed by applying it to a numerical example and the acceleration responses from a real bridge under ambient excitations (the Queensborough Bridge in Vancouver, Canada). The results obtained agree with those previously obtained on the dynamic behaviour of the Queensborough Bridge
CVA-BR against ARMAV: Comparison over Real Data from an Ambient Noise Excited Bridge L. Garibaldi and E. Giorcelli and S. Marchesiello and M. Ruzzene Key Engineering Materials 167-168 423-431 (1999)
No full textA theoretical model of oscillations of paramagnetic or diamagnetic structures subject to passive magnetic elements
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A comparison between the theoretical model and experimental outcomes of oscillations of para- or dia-magnetic structures subject to passive magnetic elements
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Protein kinase CK2: a potential therapeutic target for diverse human diseases
Full text linkCK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates (either viral and host proteins). CK2 is also considered an emerging target for neurological diseases, inflammation and autoimmune disorders, diverse ophthalmic pathologies, diabetes, and obesity. In addition, CK2 activity has been associated with cardiovascular diseases, as cardiac ischemia–reperfusion injury, atherosclerosis, and cardiac hypertrophy. The hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many years. Moreover, psychiatric disorders and syndromes due to CK2 mutations have been recently identified. On these bases, CK2 is emerging as an increasingly attractive target in various fields of human medicine, with the advantage that several very specific and effective inhibitors are already available. Here, we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings
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