190,129 research outputs found
John P. Rutter and others
No full textReport : Memorial of J. Rutter et al. [808] Extinguish Indian title to land along the entire Missouri River
John P. Rutter and others
No full text33-2Military AffairsReport : Memorial of J. Rutter et al. [808] Extinguish Indian title to land along the entire Missouri River.1855-1
Sigmistes caulias Rutter 1898
No full textSigmistes caulias Rutter, 1898. Kelp Sculpin. To 7.6 cm (3 in) TL. South-eastern Bering Sea at Pribilof Islands, Aleutian Islands from Attu Island to Tigalda Island, and Kodiak Island, western Gulf of Alaska. Benthic; depth: intertidal. All in Mecklenburg et al. (2002).Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 126, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/557800
How Cells Choose To Create Energy
No full textTo supply their energy needs, cells typically choose between utilizing glucose in the cytoplasm (aerobic glycolysis and lactic acid fermentation) or "burning" pyruvate in the mitochondria (mitochondrial carbohydrate oxidation). Although this is arguably the most fundamental metabolic decision that cells must make, prior to 2012 it was not clear how cells import pyruvate into mitochondria to fuel ATP production. That year, Rutter, Thummel and colleagues identified the heterodimeric MPC1/MPC2 complex as the mitochondrial pyruvate carrier. Their paper also identified and explained the severe metabolic defects found in families with mpc1 gene mutations. Rutter and collaborators have subsequently shown that the choice of whether or not to import pyruvate has far-reaching medical implications because stem cells and most cancer cells are glycolytic (the "Warburg Effect"). They showed that this is often because cells down-regulate MPC expression, and that MPC re-expression reverses the Warburg Effect, impedes tumor growth, and drives cell differentiation. These discoveries have revolutionized our understanding of the role of metabolic decisions in determining cell state and fate
Selected model from analysis of Rutter B items and cognitive measures (n = 11,241).
No full textSelected model from analysis of Rutter B items and cognitive measures (n = 11,241).</p
Mortality risk associated with each of the Rutter B items (n = 11,241).
No full textMortality risk associated with each of the Rutter B items (n = 11,241).</p
Frequency of neurodevelopmental markers reported on Rutter B scale by vital status.
No full textFrequency of neurodevelopmental markers reported on Rutter B scale by vital status.</p
From the Italian Alps to countries beyond Europe : the case of emigration from the Valtellina to Australia, seen through an analysis of local publications (1861-2000)
No full textIl saggio, pubblicato in inglese, studia l’evoluzione dell’emigrazione in Australia dalla Provincia di Sondrio, esaminando la stampa giornalistica locale che nel corso dei decenni si è occupata di tale argomento, descrivendolo e commentandolo in numerosi articoli. Per tracciare un quadro che segua gli sviluppi di questo vero e proprio esodo secondo un consequenziale sviluppo storico e in base a differenti prospettive di interpretazione, sono state vagliate le testate che si sono avvicendate in valle dopo l’unità italiana, privilegiandone alcune particolarmente significative per la complessiva durata della loro pubblicazione e per la diversa impostazione politica di fondo. Sono state inoltre organizzate le molte informazioni reperite, scandendole in quattro macro-segmenti temporali, cercando di cogliere le caratteristiche peculiari a ciascuno di essi
Lake Como and its mountains : geography of the natural and cultural landscapes of a complex anthropo-physical system
No full textSensing and Regulating Cellular Energy Production
No full textCells must decide when to expand mitochondrial capacity to accommodate increased energy demands. Rutter, Winge, and colleagues have shown that the ancient mitochondrial fatty acid synthesis system has a profound and unexpected regulatory role in driving mitochondrial biogenesis. The team showed that a potential cause originates from the scaffold protein, Acyl Carrier Protein 1 (ACP1), which functions in the building of fatty acids and also binds and activates a series of proteins required for mitochondrial biogenesis. The binding of proteins related to this biogenesis requires that ACP1 is acylated. ACP1 acylation requires and is rate-limited by the cofactor acetyl-CoA, which acts as the universal fuel for respiration as well as the substrate for fatty acid synthesis. Thus, this system provides an elegant mechanism for sensing and creating an increased respiratory capacity to meet demand. Thus, eukaryotic cells adjust the level of active electron transport chain complexes to match the level of acetyl-CoA "fuel" available
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