7,368 research outputs found
The cardiology community begins to embrace obesity as an important target for cardiovascular health
Full text linkNaveed Sattar and Martin K Rutter discuss the contributory role of obesity in the development and progression of cardiovascular disease, and prospects for tackling the obesity epidemic
sj-docx-1-jbr-10.1177_07487304231179595 – Supplemental material for The Associations of Chronotype and Shift Work With Rheumatoid Arthritis
No full textSupplemental material, sj-docx-1-jbr-10.1177_07487304231179595 for The Associations of Chronotype and Shift Work With Rheumatoid Arthritis by Thomas Butler, J Robert Maidstone, K Martin Rutter, T John McLaughlin, W David Ray and E Julie Gibbs in Journal of Biological Rhythms</p
Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis
No full textObjective: to compare the efficacy of different statin treatments by intensity on levels of non-high density lipoprotein cholesterol (non-HDL-C) for the prevention of cardiovascular disease in people with diabetes.Design: systematic review and network meta-analysis.Data sources: Medline, Cochrane Central Register of Controlled Trials, and Embase from inception to 1 December 2021.Review methods: randomised controlled trials comparing different types and intensities of statins, including placebo, in adults with type 1 or type 2 diabetes mellitus were included. The primary outcome was changes in levels of non-HDL-C, calculated from measures of total cholesterol and HDL-C. Secondary outcomes were changes in levels of low density lipoprotein cholesterol (LDL-C) and total cholesterol, three point major cardiovascular events (non-fatal stroke, non-fatal myocardial infarction, and death related to cardiovascular disease), and discontinuations because of adverse events. A bayesian network meta-analysis of statin intensity (low, moderate, or high) with random effects evaluated the treatment effect on non-HDL-C by mean differences and 95% credible intervals. Subgroup analysis of patients at greater risk of major cardiovascular events was compared with patients at low or moderate risk. The confidence in network meta-analysis (CINeMA) framework was applied to determine the certainty of evidence.Results: in 42 randomised controlled trials involving 20 193 adults, 11 698 were included in the meta-analysis. Compared with placebo, the greatest reductions in levels of non-HDL-C were seen with rosuvastatin at high (−2.31 mmol/L, 95% credible interval −3.39 to −1.21) and moderate (−2.27, −3.00 to −1.49) intensities, and simvastatin (−2.26, −2.99 to −1.51) and atorvastatin (−2.20, −2.69 to −1.70) at high intensity. Atorvastatin and simvastatin at any intensity and pravastatin at low intensity were also effective in reducing levels of non-HDL-C. In 4670 patients at greater risk of a major cardiovascular events, atorvastatin at high intensity showed the largest reduction in levels of non-HDL-C (−1.98, −4.16 to 0.26, surface under the cumulative ranking curve 64%). Simvastatin (−1.93, −2.63 to −1.21) and rosuvastatin (−1.76, −2.37 to −1.15) at high intensity were the most effective treatment options for reducing LDL-C. Significant reductions in non-fatal myocardial infarction were found for atorvastatin at moderate intensity compared with placebo (relative risk=0.57, confidence interval 0.43 to 0.76, n=4 studies). No significant differences were found for discontinuations, non-fatal stroke, and cardiovascular deaths.Conclusions: this network meta-analysis indicated that rosuvastatin, at moderate and high intensity doses, and simvastatin and atorvastatin, at high intensity doses, were most effective at moderately reducing levels of non-HDL-C in patients with diabetes. Given the potential improvement in accuracy in predicting cardiovascular disease when reduction in levels of non-HDL-C is used as the primary target, these findings provide guidance on which statin types and intensities are most effective by reducing non-HDL-C in patients with diabetes.Systematic review registration: PROSPERO CRD42021258819
WHY IS AMAZONITIC K-FELDSPAR AN EARMARK OF NYF-TYPE GRANITIC PEGMATITES?
No full textOral presentation- Communicating author: Martin R
Economic evaluation of a stratified transport method for Atlantic halibut (Hippoglossus hippoglossus) juveniles
No full textThe objective of this study was to evaluate a convenient, low-cost modification to conventional transfer methods for Atlantic halibut juveniles. A series of wire mesh cages were stacked within transport tanks creating a stratified transport system (STS), increasing the surface area for settlement and facilitating a more homogeneous distribution of halibut throughout the tank compared with the conventional insulated box (Unstructured, UTS). A stochastic cost-benefit analysis determined investment into a STS to be cost-effective, generating a mean benefit-cost ratio of 1.31 (95% CI, 0.68–2.00) after 2 years and a mean 5-year net present value of 85,176(9546,906–$125,630). The implementation of a STS was found to be technically feasible and economically efficient method to improve Atlantic halibut transport.Peter J. Sykes, Carol A. McClure, Debbie J. Martin-Robichaud, Charles G. Caraguel, K. Larry Hammel
Untangling Circular Drawings: Algorithms and Complexity
Full text linkWe consider the problem of untangling a given (non-planar) straight-line circular drawing δ_G of an outerplanar graph G = (V,E) into a planar straight-line circular drawing by shifting a minimum number of vertices to a new position on the circle. For an outerplanar graph G, it is clear that such a crossing-free circular drawing always exists and we define the circular shifting number shift°(δ_G) as the minimum number of vertices that need to be shifted to resolve all crossings of δ_G. We show that the problem Circular Untangling, asking whether shift°(δ_G) ≤ K for a given integer K, is NP-complete. Based on this result we study Circular Untangling for almost-planar circular drawings, in which a single edge is involved in all the crossings. In this case we provide a tight upper bound shift°(δ_G) ≤ ⌊n/2⌋-1, where n is the number of vertices in G, and present a polynomial-time algorithm to compute the circular shifting number of almost-planar drawings
The concept of the contemporary author in case of J. K. Rowling
Full text linkThe concept of the contemporary author in case of J. K. Rowling The diploma thesis deals with the contemporary concept of the author which is examined on the specific case of Joanne Kathleen Rowling. The theoretical part of the thesis focuses on the biography of the author and the previous philosophical theories concerning the concept of the author and his/her role in the identity of the literary work. The main authors of the theories are Roland Barthes, Michel Foucault, and Umberto Eco, whose concept is crucial for this thesis. The research part presents specific styles of writing which are characteristic for authors and applies this theory to the analysis of two literary works of J. K. Rowling. The conclusion of the thesis is the summary of the research and an attempt to define the concept of the contemporary author. Key words The author, authorship, literary work, pseudonym, the concept of the author, style of writing, J. K. Rowling, Robert Galbraith, Roland Barthes, Michel Foucault, Umberto Ec
Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States
Full text linkBackgroundIn the past few decades, diabetes‐related cardiovascular mortality has been steadily declining. However, the impact of the COVID19 pandemic on this trend has not been previously defined.Methods and ResultsDiabetes‐related cardiovascular mortality data were extracted for each year between 1999 and 2020 from the Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research (WONDER) database. Regression analysis was used to calculate the trend in the 2 decades before the pandemic (1999–2019) and thereby estimate the excess cardiovascular mortality in 2020. There was a 29.2% fall in the diabetes‐related cardiovascular age‐adjusted mortality rate between 1999 to 2019, largely driven by a 41% decrease in ischemic heart disease deaths. In comparison to 2019, there was an overall 15.5% increase in the diabetes‐related cardiovascular age‐adjusted mortality rate in the first year of the pandemic, mainly due to a 14.1% rise in ischemic heart disease deaths. Younger patients (under 55 years) and the Black population experienced the greatest increase in diabetes‐related cardiovascular age‐adjusted mortality rate (24.0% and 25.3%, respectively). Trend analysis estimated 16 009 excess diabetes‐related cardiovascular deaths in 2020, with the majority due to ischemic heart disease (8504). Black and Hispanic or Latino populations had at least one‐fifth of their 2020 diabetes‐related cardiovascular age‐adjusted mortality rate as excess deaths (22.3% and 20.2%, respectively).ConclusionsThere was a sharp rise in diabetes‐related cardiovascular mortality during the first pandemic year. Black, Hispanic or Latino, and young people showed the largest increases in diabetes‐related cardiovascular mortality. Targeted health policies could help address the disparities observed in this analysis
Martin Buber Collection 1897-1980 Bulk dates: 1921-1929
No full textThe Martin Buber Collection holds various papers of this philosopher, with a focus on his work. More than half the collection consists of his letters to Franz Rosenzweig, including a number of them devoted to their collaborative translation of the Bible; lectures he gave at the Freies Jüdisches Lehrhaus in Frankfurt am Main; and a discussion of Buber’s book Ich und Du (I and Thou). In addition the collection holds texts of some of Martin Buber's lectures, photographs, a few letters to others, invitations and an article.The following individuals are mentioned in this collection:Ahren, Yitzhak; Balthasar, H. von; Billigheimer, Samuel; Diamond, Malcolm; Fackenheim, Emil; Farber, Leslie; Fox, Marvin; Friedman, Maurice; Galliner, Arthur; Galliner, Helmut; Gandhi, Mohandas K.; Glatzer, Nahum; Goes, Albrecht; Guggenheim, Siegfried; Heinemann, F.; Hesse, Ninon; Hocking, William Ernst; Hohoff, Curt; Kaplan, Mordechai; Kaufmann, Fritz; Kerenyi, Karl; Klotz, Elena; Kohn, Hans; Kreutzberger, Max; Kuhn, Helmuth; Landauer, Gustav; Levin, Meyer; Levinas, Emmanuel; Loewenberg, Frank; Mailenburg, James; Marcel, Gabriel; Michael, Max; Newman, Louis; Niebuhr, Reinhold; Pfuetze, Paul; Porter, Jack Nusan; Ross, Irvin; Rotenstreich, Nathan; Schneider, Herbert; Scholem, Gershom; Schorsch, Ismar; Sholem, Gershom; Simon, Ernst; Simon, Isidor; Stahr, Adolf; Tagore, Rabindranath; Taubes, Jacob; Weltmann, Lutz; Weltsch, Robert; Wheelwright, Philip; Wilkers, KarldigitizedDigital ImageBorn in Vienna on February 2, 1878, Martin Buber studied philosophy and art history at various European universities, became active in the Zionist movement, and worked as an author, editor, and publisher. Moving to Berlin in 1906, and to Heppenheim near Frankfurt am Main in 1916, he published highly regarded philosophical and theological works. Buber emigrated to Palestine in 1938, where he taught at the Hebrew University in Jerusalem until his death on June 13, 1965.Articles on Martin Buber may be found in ‘Manuscripts about Martin Buber’, MF 189 (available online), and in the Martin Buber Clippings Collection.Photographs removed to Photograph CollectionProcesse
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