166,277 research outputs found
Testimony of William Rutter
No full textRutter, a UCSF scientist, discussed insulin-producing experiments, relevant NIH guidelines, and patenting procedures. He testified on August 21st and 22nd
Rutter, J H, QX12681
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/414862Surname: RUTTER. Given Name(s) or Initials: J H. Military Service Number or Last Known Location: QX12681. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 44118.234933
Item: [2016.0049.47123] "Rutter, J H, QX12681
Rutter, J E H, VX3947
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/414865Surname: RUTTER. Given Name(s) or Initials: J E H. Military Service Number or Last Known Location: VX3947. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 2204.234942
Item: [2016.0049.47126] "Rutter, J E H, VX3947
How Cells Choose To Create Energy
No full textTo supply their energy needs, cells typically choose between utilizing glucose in the cytoplasm (aerobic glycolysis and lactic acid fermentation) or "burning" pyruvate in the mitochondria (mitochondrial carbohydrate oxidation). Although this is arguably the most fundamental metabolic decision that cells must make, prior to 2012 it was not clear how cells import pyruvate into mitochondria to fuel ATP production. That year, Rutter, Thummel and colleagues identified the heterodimeric MPC1/MPC2 complex as the mitochondrial pyruvate carrier. Their paper also identified and explained the severe metabolic defects found in families with mpc1 gene mutations. Rutter and collaborators have subsequently shown that the choice of whether or not to import pyruvate has far-reaching medical implications because stem cells and most cancer cells are glycolytic (the "Warburg Effect"). They showed that this is often because cells down-regulate MPC expression, and that MPC re-expression reverses the Warburg Effect, impedes tumor growth, and drives cell differentiation. These discoveries have revolutionized our understanding of the role of metabolic decisions in determining cell state and fate
Sensing and Regulating Cellular Energy Production
No full textCells must decide when to expand mitochondrial capacity to accommodate increased energy demands. Rutter, Winge, and colleagues have shown that the ancient mitochondrial fatty acid synthesis system has a profound and unexpected regulatory role in driving mitochondrial biogenesis. The team showed that a potential cause originates from the scaffold protein, Acyl Carrier Protein 1 (ACP1), which functions in the building of fatty acids and also binds and activates a series of proteins required for mitochondrial biogenesis. The binding of proteins related to this biogenesis requires that ACP1 is acylated. ACP1 acylation requires and is rate-limited by the cofactor acetyl-CoA, which acts as the universal fuel for respiration as well as the substrate for fatty acid synthesis. Thus, this system provides an elegant mechanism for sensing and creating an increased respiratory capacity to meet demand. Thus, eukaryotic cells adjust the level of active electron transport chain complexes to match the level of acetyl-CoA "fuel" available
Michael Rutter
No full textExcerpt
Michael Rutter was born August 15th, 1933 to Winifred and Llewellyn Rutter in Lebanon, where his father was working as a doctor. He returned with his parents to England when he was 3-years-old. In 1940, at the age of 6-years-old, Rutter and his younger sister were evacuated to North America due to fear of German invasion of the British Isles. He and his sister were taken in by different families in the United States and only living together a few months near the end of their four year stay abroad. Rutter denied feeling separated from his parents during his stay abroad, indicating that his parents wrote letters regularly
John P. Rutter and others
No full textReport : Memorial of J. Rutter et al. [808] Extinguish Indian title to land along the entire Missouri River
Can inattention/overactivity be an institutional deprivation syndrome?
No full textElevated rates of attention deficit and overactivity have been noted previously in samples of institution-reared children. This study examined the hypothesis that inattention/overactivity(I/O) might constitute a specific deprivation syndrome. One hundred and sixty five children adopted at varying ages (e.g., 0–42 months of age) into the UK following severe early deprivation were compared with 52 within-UK adoptees who did not suffer deprivation. The children were rated by teachers and parents on levels of I/O, conduct difficulties, and emotional difficulties using the Revised Rutter Scales. Data were collected at age 6 for the entire sample and at age 4 for the UK adoptees and for the subsample of Romanian children who entered the UK before the age of 2 years. Mean level analyses suggested a significant effect of duration of deprivation on I/O, but not on conduct or emotional difficulties. The effects of duration of deprivation were specific to I/O and were not accounted for by low birth weight, malnutrition, or cognitive impairment. Levels of I/O correlated with attachment disturbances. Furthermore, the effects of duration of deprivation on I/O did not attenuate over time. We conclude that I/O may well constitute an institutional deprivation syndrome, but that the type of attention deficit and overactivity exhibited by these children may present a different clinical picture from that of ordinary varieties of attention deficit disorder or hyperkinetic syndrome
John P. Rutter and others
No full text33-2Military AffairsReport : Memorial of J. Rutter et al. [808] Extinguish Indian title to land along the entire Missouri River.1855-1
N. J. Sewell-Rutter, Guilt by Descent. Moral Inheritance and Decision Making in Greek Tragedy, 2007
No full textByl Simon. N. J. Sewell-Rutter, Guilt by Descent. Moral Inheritance and Decision Making in Greek Tragedy, 2007. In: L'antiquité classique, Tome 78, 2009. pp. 269-270
- …
