1,721,172 research outputs found
Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives
No full textFaraone, Immacolata, Russo, Daniela, Genovese, Salvatore, Milella, Luigi, Monn, Magnus, e, Epifano, Francesco, Fiorito, Serena (2021): Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives. Phytochemistry (112781) 187: 1-10, DOI: 10.1016/j.phytochem.2021.112781, URL: http://dx.doi.org/10.1016/j.phytochem.2021.11278
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Efectos del Vinorelbine in vitro e in vivo sobre un carcinoma de células transicionales de vejiga
No full textLos tratamientos disponibles para los pacientes con carcinoma superfich de vejiga no ofrecen resultados totalmente satisfactorios en cuanto a la profilaxis de la recurrencia tumoral o de la progresión a cáncer invasor. Por este motivo, se buscan drogas alternativas eficaces en la prevención. En este caso, se ensayó con un alcaloide de la Vrnm de segunda generación, de conocida actividad antineoplásica sobre diferentes tipos de tumores. En nuestros estudios, el Vinorelbine (VNR) demostró poseer actividad antiproliferativa (IC 50: 21,6 nM) sobre MB-49, una línea celular derivada de un carcinoma de células transicionales de vejiga murino. Se estudió el comportamiento in vitro de la línea MB-49en presencia de VNR, en relación a los eventos esenciales para el proceso invasivo. El VNRinterfirió significativamente con la capacidad invasiva de MB-49 (42,6% y 62,5% de inhibición para 1 y 10 nM de VNR respectivamente) y con la respuesta migratoria de dichas células frente al medio quimioatractante (43,2%y 75,62%de inhibición para 1 y 10 nM de VNR respectivamente). En base a los resultados, se eligió un modelo animal adecuado para el estudio del VNR como posible tratamiento profiláctico de la recurrencia y/o progresión tumoral del cáncer de vejiga. Los ratones C57BI/6], luego de ser implantados inuavesicalmente con células singeneicas fueron inoculados por la misma vía con VNR (0,2mg). Se observó menor incidencia tumoral en aquellos animales tratados con VNRluego de 30 minutos o 24 hs respecto de los controles (66%,36% y 86% respectivamente). Además, según el análisis histopatológico de las vejigas, existe mayor volumen tumoral y grado de invasividad de la pared vesical en aquellos no tratados, respecto a los expuestos a la droga. Estas características permiten postular al VNR como un potencial candidato a la quimioterapia intravesical contra el cáncer superficial de vejiga.Fil: Russo, Daniela Marta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Les marchés de produits dérivés de gré à gré et la question de l’accès aux banques centrales des contreparties centrales
No full textThe financial market turmoil has demonstrated the importance of OTC derivatives markets for financial stability. In particular, the crisis has exposed weaknesses in OTC markets that had contributed to the build-up of systemic risk. Therefore, the G20 has called for reforms, promoting especially the establishment of central counterparties (CCPs). This article documents the importance of CCPs for systemic stability and highlights the need for strengthening its resilience. In this regard, we review various options for CCPs to access central bank facilities. We conclude that when designing the framework of services and instruments that a central bank may choose to offer to CCPs, it will have to consider a wide range of aspects, including financial stability considerations and its implications for monetary policy.
Classification JEL : G18, G23, G28.L’agitation du marché financier a souligné le rôle joué par les marchés dérivés de gré à gré dans la stabilité financière. La crise a notamment mis en lumière les faiblesses des marchés de gré à gré qui ont contribué à l’augmentation du risque systémique. Le G20 a donc demandé des réformes, appelant notamment à l’établissement de contreparties centrales (CCP). Cet article étudie l’importance des contreparties centrales dans la stabilité systémique, dont il est indispensable de renforcer la résilience. À cet égard, les auteurs étudient plusieurs options possibles pour permettre aux contreparties centrales d’accéder aux services des banques centrales. On peut conclure qu’à l’heure de concevoir les services et instruments qu’une banque centrale pourrait offrir aux contreparties centrales, elle devra tenir compte de nombreux aspects, dont la stabilité financière et ses conséquences sur la politique monétaire.
Classification JEL : G18, G23, G28.Russo Daniela, Tumpel-Gugerell Gertrude. Les marchés de produits dérivés de gré à gré et la question de l’accès aux banques centrales des contreparties centrales. In: Revue d'économie financière, n°101, 2011. Le risque systémique 2. Repenser la supervision. pp. 37-52
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