1,721,173 research outputs found

    Age-related changes in the response of intestinal cells to parathyroid hormone

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    The concept of the role(s) of parathyroid hormone (PTH), has expanded from that on acting on the classical target tissues, bone and kidney, to the intestine where its actions are of regulatory and developmental importance: regulation of intracellular calcium through modulation of second messengers and, activation of mitogenic cascades leading to cell proliferation. Several causes have been postulated to modify the hormone response in intestinal cells with ageing, among them, alterations of PTH receptor (PTHR1) binding sites, reduced expression of G proteins and hormone signal transduction changes. The current review summarizes the actual knowledge regarding the molecular and biochemical basis of age-impaired PTH receptor-mediated signaling in intestinal cells. A fundamental understanding of why PTH functions are impaired with age will enhance our understanding of its importance in intestinal cell physiology.Fil: Russo, Ana Josefa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentin

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    La enseñanza de Psicología en la Facultad de Ciencias Sociales de la Universidad de la República. El caso de los Planes de estudio 1992 y 2009

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    La presente investigación se propuso indagar respecto a la enseñanza de contenidos psicológicos en la formación de grado de las licenciaturas que ofrece la Facultad de Ciencias Sociales (FCS) de la Universidad de la República. El estudio de la didáctica específica de Psicología en la currícula de diferentes servicios universitarios constituye un tópico no indagado aún en el ámbito académico, por lo que este estudio pretende contribuir al análisis de los factores que determinan esa selección y cómo se produce la transposición didáctica de los saberes psicológicos, para ser enseñados en la formación de profesionales de otra área de conocimiento. Se utilizó una metodología cualitativa basada en el estudio de caso, realizándose el análisis de los documentos curriculares que incluyen: los Planes de Estudio 1992 y 2009 de la FCS, el análisis de contenido de los programas de curso de las asignaturas de Psicología y las entrevistas en profundidad realizadas a directores, coordinadores y docentes de la institución. Los resultados obtenidos muestran un cambio en la selección de los contenidos psicológicos con respecto al Plan de Estudios de 1992 y una nueva disposición de los mismos a partir de las modificaciones e innovaciones de las asignaturas que se imparten. La promoción de la formación interdisciplinar y diversificación de contenidos, muestra la superación de contenidos psicológicos compartimentados y apunta a un abordaje interdisciplinar de temas, habilitando una oferta de cursada optativa para todas las licenciaturas. Este estudio de caso puede ser considerado un aporte para repensar los contenidos básicos en la enseñanza de Psicología para la formación de los cientistas sociales y para construir nuevas configuraciones didácticas pertinentes a las necesidades que se requieran en esta área de conocimiento.This research aimed to investigate the teaching of psychological content within the degrees offered by the Faculty of Social Sciences (FCS) of the University of the Republic. The study of specific teaching of psychology within the university´s centres´ curricula is a topic not yet investigated in the academia. Therefore this study aims to contribute to the analysis of the factors that determine the content selection and how didactic transposition occurs for psychological knowledge to be taught in the training of professionals in other areas of knowledge. A qualitative methodology based on case study was used. Curriculum documents were analized, including: Curriculum in 1992 and in 2009 at FCS, content analysis of course syllabi for the subjects of Psychology and interviews made to directors, coordinators and profesors from the institution. The results show a change in the content selection regarding Curriculum 1992 and a new order related to the changes and innovations made to the subjects taught. Promoting interdisciplinary training and diversification of contents, sample overcoming psychological contents compartmentalized and points to an interdisciplinary approach to issues, enabling the offer of optional subjects for all degrees. This case study can be considered as a contribution to reconsider the basic contents in Psychology teaching for social scientists and to build new social and educational settings according to the needs and requirements in this area of knowledge.Introducción -- Capítulo 1. La construcción del problema de investigación -- 1.1. El tema de investigación -- 1.2. Justificación y pertinencia de la investigación -- 1.3. La determinación del caso -- Capítulo 2. El marco teórico -- 2.1. Didáctica: Las perspectivas conceptuales -- 2.2. El Currículo: dimensiones para su estudio -- 2.3. La enseñanza específica de la Psicología en las Ciencias Sociales -- Capítulo 3. Metodología -- 3.1. Fundamentación del estudio cualitativo -- 3.2. El diseño de investigación -- Capítulo 4. Resultados -- 4.1. El Plan de Estudio 2009 -- 4.2. Los documentos curriculares que explicitan contenidos psicológicos -- 4.3. Las entrevistas realizadas -- Capítulo 5. Discusión y análisis de los resultados -- 5.1. El Plan de Estudios 2009 -- 5.2. Las dimensiones didáctico curriculares -- Capítulo 6. Conclusiones y Tareas Emergentes – Bibliografía -- Anexo

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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