30 research outputs found
Social practice in the legal secretariat of the municipality of Bucaramanga to monitor and control court rulings on class actions duly enforced in the second instance, for which the infrastructure secretariat has been designated for compliance from September 19, 2004, to July 31, 2025.
No full textTítulo: Practica social en la secretaría jurídica del municipio de Bucaramanga para realizar el
seguimiento y control de los fallos judiciales de acciones populares debidamente ejecutoriados en
segunda instancia que para su cumplimiento se haya designado a la secretaría de infraestructura
desde el 19 de septiembre de 2004 hasta el 31 de julio de 2025.
Autor: Gamaliel Eliu Garcia Rojas
Palabras Clave: Sistema Jurídico Integral, SAMAI, Consulta de Procesos Nacional Unificada
Descripción: El Municipio de Bucaramanga es un ente territorial encargado del desarrollo y el
mejoramiento de la calidad de vida de sus habitantes, basado en la efectividad, transparencia y
legalidad, prestando oportuna y eficientemente servicios a los diferentes sectores de la comunidad,
acorde a las necesidades de la ciudadanía, las exigencias del medio y el cumplimiento de la
Constitución y las Leyes, fomentando el autocontrol y la autogestión, para alcanzar la satisfacción
de los usuarios. Centrada en un sistema de gerencia participativa, garantizando la identificación y
la prevención de las condiciones y factores que afectan la salud y seguridad de los servidores
públicos, para garantizar un ambiente de trabajo adecuado, el uso eficiente de los recursos y el
compromiso para estar a la vanguardia en conocimientos, técnicas y metodologías que contribuyan
al desarrollo de la competitividad y continua del Sistema Integrado de Gestión de Calidad.
En el marco de sus competencias el municipio de Bucaramanga debe propender por la defensa
judicial en todas sus dependencias y la prevención del daño antijurídico, en ese sentido, esta
práctica en la secretaría jurídica busca identificar falencias y corregirlas en el cumplimiento de los
fallos judiciales producto de acciones populares ejecutoriadas en segunda instanciaPregradoAbogadoTitle: Social practice in the legal secretariat of the municipality of Bucaramanga to monitor and
control court rulings on class actions duly enforced in the second instance, for which the
infrastructure secretariat has been designated for compliance from September 19, 2004, to July 31,
2025.
Author: Gamaliel Eliu Garcia Rojas
Key Words: Comprehensive Legal System, SAMAI, Unified National Process Inquiry
Description: The Municipality of Bucaramanga is a territorial entity responsible for the
development and improvement of the quality of life of its inhabitants, based on effectiveness,
transparency, and legality, providing timely and efficient services to different sectors of the
community, in accordance with the needs of citizens, the demands of the environment, and
compliance with the Constitution and laws, promoting self-control and self-management to
achieve user satisfaction. Focused on a participatory management system, it guarantees the
identification and prevention of conditions and factors that affect the health and safety of public
servants, to ensure an adequate work environment, the efficient use of resources, and a
commitment to being at the forefront of knowledge, techniques, and methodologies that contribute
to the development of competitiveness and the continuity of the Integrated Quality Management
System.
Within the scope of its powers, the municipality of Bucaramanga must strive for legal defense in
all its departments and the prevention of unlawful damage. In this regard, this practice in the legal
secretariat seeks to identify shortcomings and correct them in compliance with court rulings
resulting from popular actions enforced in the second instance
La postura de garante de los altos funcionarios como criterio configurador del delito de homicidio doloso en las manifestaciones sociales
No full textEl presente trabajo de investigación tiene como fin determinar criterios jurídicos en la postura de garante de los altos funcionarios, a partir del análisis y verificación del estatus que poseen, en razón del cargo, como criterio configurador del delito de homicidio doloso en las manifestaciones sociales. La tesis explora-como referencia-la denuncia constitucional N°1502020, en contra del ex Presidente Merino
de Lama,
como
presunto
autor
del
delito
en
cuestión.
De
ahí
que, se estudió el delito de omisión impropia, en tanto que, el sujeto activo/autor tiene incito el nexo
de evitación, por lo que, está obligado a evitar que se produzca el resultado lesivo, y permite que se
afecte al bien jurídico.
Frente a ello, el estudio desarrollado tiene sustento en la tesis de infracción de deber, en la cual el estatus
del alto funcionario por su condición especial y personal, no tiene relación directa con el resultado lesivo en el delito de homicidio.
En tal sentido,no es posible pretender encajar la tesis del dominio del hecho, por cuanto, no domina
ni el riesgo típico que exige un deber específico-deber que el Presidente no defrauda-previsto en una
norma extra-penal.
De ahí que, se propone la implementación de los criterios jurídicos de: el nexo de evitación, la previsibilidad y el hombre promedio en sociedad; en la postura de garante.
Y a fin de operativizar los conceptos propuestos, se concluye que, no es posible atribuir responsabilidad
penal al Presidente de la República.The purpose of this research work is to determine legal criteria regarding the position of guarantor held by high-ranking officials, based on the analysis and verification of the status they possess by virtue of their office, as a determining factor in the crime of intentional homicide during social demonstrations. The thesis explores, as a reference, the constitutional complaint No. 150-2020 against former President Merino de Lama as the alleged author of the aforementioned crime. From there, improper omission offenses were studied, considering that the active/author subject has a duty to prevent the harmful outcome and allows the infringement of the legal interest. In light of this, the study is grounded in the theory of breach of duty, in which the status of a high-ranking official, due to their special and personal condition, does not have a direct relationship with the harmful outcome in the crime of homicide. Thus, it's not possible to fit the theory of control of the act, as there is no control over the typical risk that
requires a specific duty - a duty that the president does not breach - provided by an extrapenal norm. Therefore, the implementation of the following legal criteria in the position of guarantor is proposed: the duty to prevent, foreseeability, and the average person in society. In order to operationalize the proposed concepts, it is concluded that it is not possible to attribute criminal responsibility to the President of the Republic
Direct visualization of the reaction transformation and signal amplification in a DNA molecular machine with total internal reflection fluorescence microscopy
No full textIn this study, as a proof of concept, the signal amplification in an artificial DNA molecular machine was directly visualized via total internal reflection fluorescence microscopy (TIRFM). The molecular machine brought about obvious morphology change in DNA nanostructures as well as signal amplifications. On one hand, through a triggered and autonomically repeated RCA, a DNA nano-complex featuring a locked circular DNA template (serving as raw feed) was converted into a long periodically repeated strand, i.e. the RCA products. Furthermore, this RCA was repeated in three controllable reaction phases, bring about progressive signal amplification. It was testified that the RCA products (presented as long thread-like fluorescent objects) can be easily distinguished from the inputted DNA probes (presented as fluorescent dots), thus the transformation in reaction can be visualized. Also, by quantitive counting of the aforementioned fluorescence objects, the progress of the reaction through the phases, along with time, and over the lysozyme concentration can be demonstrated through TIRFM visualization. Overall, it was demonstrated that TIRFM is an efficient approach to quantitively visualize the biochemical processes at single-molecule level
Physiological and metabolic changes of purslane (Portulaca oleracea L.) in response to drought, heat and combined stresses
No full textPurslane (Portulaca oleracea L.) is a fleshy herbaceous plant. So far, little information is available on the response of this plant to combined drought and heat stress. In this study, changes in physiological and metabolic levels were characterized after treatments with drought, heat and combined stresses. Both individual and combined stress treatments increased malondialdehyde (MDA), electrolyte leakage (EL), O2•− and activities of superoxide dismutase (SOD), peroxidase (POD), while declined chlorophyll content. No significant differences were found between control and treatments in leaf water content (LWC) and catalase (CAT) activity. Additionally, 37 metabolic compounds were detected in purslane. Through pathway analysis, 17 metabolites were directly involved in the glycolysis metabolic pathway. The present study indicated that combined drought and heat stress caused more serious damage in purslane than individual stress. To survive, purslane has a high capability to cope with environmental stress conditions through activation of physiological and metabolic pathways
Identifying critical differentiation state of MCF-7 cells for breast cancer by dynamical network biomarkers
No full textIdentifying the pre-transition state just before a critical transition during a complex biological process is a challenging task, because the state of the system may show neither apparent change nor clear phenomenon before this critical transition during the biological process. By exploring rich correlation information provided by high-throughput data, the dynamical network biomarker (DNB) can identify the pre-transition state. In this work, we apply DNB to detect an early-warning signals of breast cancer on the basis of gene expression data of MCF-7 cell differentiation. We find a number of the related modules and pathways in the samples, which can be used not only as the biomarkers of cancer cells but also as the drug targets. Both functional and pathway enrichment analyses validate the results
Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism
No full textThe recent discovery of DNA methylation in the nematode T. spiralis may raise the possibility of using it as a potential model organism for epigenetic studies instead of C. elegans, which is deficient in this important epigenetic modification. In contrast to the free-living nematode C. elegans, T. spiralis is a parasitic worm that possesses a complicated life cycle and undergoes a complex developmental regulation of genes. We emphasise that the differential methylomes in the different life-history stages of T. spiralis can provide insight on how DNA methylation is triggered and regulated. In particular, we have demonstrated that DNA methylation is involved in the regulation of its parasitism-related genes. Further computational analyses indicated that the regulatory machinery for DNA methylation can also be found in the T. spiralis genome. By a logical extension of this point, we speculate that comprehensively addressing the epigenetic machinery of T. spiralis may help to understand epigenetics in invertebrates. Furthermore, considering the implication of epigenetics in metazoan parasitism, using T. spiralis as an epigenetic model organism may further contribute to drug development against metazoan parasites
Citrus PH5-like H+-ATPase genes: identification and transcript analysis to investigate their possible relationship with citrate accumulation in fruits
No full textPH5 is a petunia gene that encodes a plasma membrane H+-ATPase and determines the vacuolar pH. The citrate content of fruit cell vacuoles influences citrus organoleptic qualities. Although citrus could have PH5-like homologs that are involved in citrate accumulation, the details are still unknown. In this study, extensive data-mining with the PH5 sequence and PCR amplification confirmed that there are at least eight PH5-like genes (CsPH1-8) in the citrus genome. CsPHs have a molecular mass of approximately 100 kDa, and they have high similarity to PhPH5, AtAHA10 or AtAHA2 (from 64.6% to 80.9%). They contain 13-21 exons and 12-20 introns and were evenly distributed into four subgroups of the P3A-subfamily (CsPH1, CsPH2, and CsPH3 in Group I, CsPH4 and CsPH5 in Group II, CsPH6 in Group IV, and CsPH7 and CsPH8 in Group III together with PhPH5). A transcript analysis showed that CsPH1, 3, and 4 were predominantly expressed in mature leaves, whereas CsPH2 and 7 were predominantly expressed in roots, CsPH5 and 6 were predominantly expressed in flowers, and CsPH8 was predominantly expressed in fruit juice sacs. Moreover, the CsPH transcript profiles differed between orange and pummelo, as well as between high-acid and low-acid cultivars. The low-acid orange ‘Honganliu’ exhibits low transcript levels of CsPH3, CsPH4, CsPH5, and CsPH8, whereas the acid-free pummelo has only a low transcript level of CsPH8. In addition, ABA injection increased the citrate content significantly, which was accompanied by the obvious induction of CsPH2, 6, 7, and 8 transcript levels. Taken together, we suggest that CsPH8 seems likely to regulate citrate accumulation in the citrus fruit vacuole
Deep learning methods for enabling real-time gravitational wave and multimessenger astrophysics
No full textA new era of gravitational wave (GW) astronomy has begun with the recent detections by LIGO. However, we need real-time observations of GW signals and their electromagnetic (EM) and astro-particle counterparts to unlock its full potential for scientific discoveries. Extracting and classifying the wide range of modeled and unmodeled GWs, whose amplitudes are often much weaker than the background noise, and rapidly inferring accurate parameters of their source is crucial in enabling this scenario of real-time multimessenger astrophysics. Identifying and automatically clustering anomalous non-Gaussian transient noises (glitches) that frequently contaminate the data and separating them from true GW signals is yet another difficult challenge.
Currently, the most sensitive data analysis pipelines are limited by the extreme computational costs of template-matching methods and thus are unable to scale to all types of GW sources and their full parameter space. Accurate numerical models of GW signals covering the entire range of parameters including eccentric and spin-precessing compact binaries, which are essential to infer the astrophysical parameters of an event, are not available. Searches for unmodeled and anomalous signals do not have sufficient sensitivity compared to the targeted searches. Furthermore, existing search pipelines are not optimal for dealing with the non-stationary, non-Gaussian noise in the detectors. This indicates that many critical events will go unnoticed. The primary objective of this thesis is to resolve these issues via deep learning, a state-of-the-art machine learning method based on artificial neural networks.
In this thesis we develop robust GW analysis algorithms for analyzing real LIGO/Virgo data based on deep learning with neural networks, that overcomes many limitations of existing techniques, allowing real-time detection and parameter estimation modeled GW sources and unmodeled GW bursts as well as classification and unsupervised clustering of anomalies and glitches in the detectors. This pipeline is designed to be highly scalable, therefore it can be trained with template banks of any size to cover the entire parameter-space of eccentric and spin-precessing black hole binaries as well as other sources and also optimized based on the real-time characteristics of the complex noise in the GW detectors.
This deep learning framework may also be extended for low-latency analysis of the raw big data collected across multiple observational instruments to further facilitate real-time multimessenger astrophysics, which promises groundbreaking scientific insights about the origin, evolution, and destiny of the universe. In addition, this work introduces a new paradigm to accelerate scientific discovery by using data derived from high-performance physics simulations on supercomputers to train artificial intelligence algorithms that exploit emerging hardware architectures.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01The student, Daniel George, accepted the attached license on 2018-12-06 at 00:49.The student, Daniel George, submitted this Dissertation for approval on 2018-12-06 at 01:03.This Dissertation was approved for publication on 2018-12-07 at 07:40.DSpace SAF Submission Ingestion Package generated from Vireo submission #13229 on 2019-02-08 at 11:41:24Made available in DSpace on 2019-02-08T18:44:40Z (GMT). No. of bitstreams: 2
GEORGE-DISSERTATION-2018.pdf: 17941667 bytes, checksum: e0e0c87bdfc2d80f0f05249fe6629633 (MD5)
LICENSE.txt: 4210 bytes, checksum: e8bea6db131931d703d8fb97bb52f411 (MD5)
Previous issue date: 2018-12-07Embargo set by: Seth Robbins for item 109973
Lift date: 2021-02-08T18:44:50Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 109973 on 2021-02-09T10:15:30Z
The effects of Fe2O3 nanoparticles on physiology and insecticide activity in non-transgenic and Bt-transgenic cotton
No full textAs the demands for nanotechnology and nanoparticle (NP) applications in agriculture increase, the ecological risk has drawn more attention because of the unpredictable results of interactions between NPs and transgenic crops. In this study, we investigated the effects of various concentrations of Fe2O3 NPs on Bt-transgenic cotton in comparison with conventional cotton for 10 days. Each treatment was conducted in triplicate, and each experiment was repeated three times. Results demonstrated that Fe2O3 nanoparticles (NPs) inhibited the plant height and root length of Bt-transgenic cotton and promoted root hairs and biomass of non-transgenic cotton. Nutrients such as Na and K in Bt-transgenic cotton roots increased, while Zn contents decreased with Fe2O3 NPs. Most hormones in the roots of Bt-transgenic cotton increased at low Fe2O3 NP exposure (100 mg·L−1) but decreased at high concentrations of Fe2O3 NPs (1000 mg·L−1). Fe2O3 NPs increased the Bt-toxin in leaves and roots of Bt-transgenic cotton. Fe2O3 NPs were absorbed into roots, then transported to the shoots of both Bt-transgenic and non-transgenic cottons. The bioaccumulation of Fe2O3 NPs in plants might be a potential risk for agricultural crops and affect the environment and human health
GidA, a tRNA modification enzyme, contributes to the growth and virulence of Streptococcus suis serotype 2
No full textGlucose-inhibited division protein (GidA), is a tRNA modification enzyme functioning together with MnmE in the addition of a carboxymethylaminomethyl group to position 5 of the anticodon wobble uridine of tRNA. Here, we report a GidA homologue from a Chinese isolate SC-19 of the zoonotic Streptococcus suis serotype 2 (SS2). gidA disruption led to a defective growth, increased capsule thickness, and reduced hemolytic activity. Moreover, the gidA deletion mutant (ΔgidA) displayed reduced mortality and bacterial loads in mice, reduced ability of adhesion to and invasion in epithelial cells, and increased sensitivity to phagocytosis. The iTRAQ analysis identified 372 differentially expressed (182 up- and 190 down-regulated) proteins in ΔgidA and SC-19. Numerous DNA replication, cell division and virulence associated proteins were downregulated, whereas many capsule synthesis enzymes were upregulated by gidA disruption. This is consistent with the phenotypes of the mutant. Thus, GidA is a translational regulator that plays an important role in the growth, cell division, capsule biosynthesis, and virulence of SS2. Our findings provide new insight into the regulatory function of GidA in bacterial pathogens
