1,721,044 research outputs found
Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition
No full textCannabis is still the most widely used illicit drug around the world. While its use has always been prevalent among adolescents, recent evidence suggests that its consumption is also increasing among other population groups, such as pregnant women and aged people. Given the known impact of cannabis on brain development and behavior, it is important to dissect the possible long-term impact of its use across different age groups, especially on measures of cognitive performance. Animal models of cannabinoid exposure have represented a fundamental tool to characterize the long-lasting consequences of cannabinoids on cognitive performance and helped to identify possible factors that could modulate cannabinoids effects in the long term, such as the age of exposure and doses administered. This scoping review was systematically conducted using PubMed and includes papers published from 2015 to December 2021 that examined the effects of cannabinoids, either natural or synthetic, on cognitive performance in animal models where exposure occurred in the prenatal period, during adolescence, or in older animals. Overall, available data clearly point to a crucial role of age in determining the long-term effect of cannabinoid on cognition, highlighting possible detrimental consequences during brain development (prenatal and adolescent exposure) and beneficial outcomes in old age. In contrast, despite the recent advances in the field, it appears difficult to clearly establish a possible role of dosage in the effects of cannabinoids on cognition, especially when the adolescent period is taken into account
Impact of Endocannabinoid System Manipulation on Neurodevelopmental Processes Relevant to Schizophrenia
No full textThe neurodevelopmental hypothesis of schizophrenia has received much support from epidemiological and neuropathological studies and provides a framework to explain how early developmental abnormalities might manifest as psychosis in early adulthood. According to this theory, the onset of schizophrenia is likely the result of a complex interplay between a genetic predisposition and environmental factors whose respective influence might contribute to the etiology and progression of the disorder. The two most sensitive windows for neurodevelopment are the prenatal/perinatal and the adolescent windows, both of which are characterized by specific processes impinging upon brain structure and functionality, whose alterations may contribute to the onset of schizophrenia. An increasing number of articles suggest the involvement of the endocannabinoid system in the modulation of at least some of these processes, especially in the prenatal/perinatal window. Thus, it is not surprising that disturbing the physiological role of endocannabinoid signaling in these sensitive windows might alter the correct formation of neuronal networks, eventually predisposing to neuropsychiatric diseases later in life. We review the most recent preclinical studies that evaluated the impact of endocannabinoid system modulation in the two sensitive developmental windows on neurodevelopmental processes that possess a specific relevance to schizophrenia
Susceptibility to Psychiatric Diseases After Cannabis Abuse in Adolescence: Animal Models
No full textA. Cicu et F. Messineo, Trattato di diritto civile e commerciale, t. XIX, LHpoteca immobiliare e mobiliare, par D. Rubino, t. XXII, La donazione, par A. Toerente
No full textA. Cicu et F. Messineo, Trattato di diritto civile e commerciale, t. XIX, LHpoteca immobiliare e mobiliare, par D. Rubino, t. XXII, La donazione, par A. Toerente. In: Revue internationale de droit comparé. Vol. 12 N°3, Juillet-septembre 1960. pp. 635-636
A. Cicu et F. Messineo, Trattato di diritto civile e commerciale, t. XIX, LHpoteca immobiliare e mobiliare, par D. Rubino, t. XXII, La donazione, par A. Toerente
No full textA. Cicu et F. Messineo, Trattato di diritto civile e commerciale, t. XIX, LHpoteca immobiliare e mobiliare, par D. Rubino, t. XXII, La donazione, par A. Toerente. In: Revue internationale de droit comparé. Vol. 12 N°3, Juillet-septembre 1960. pp. 635-636
Meccanismi adattativi da esposizione cronica ai cannabinoidi: aspetti comportamentali e cellulari
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Sensitizzazione al D9-tetraidrocannabinolo: analisi comportamentali e correlati cellulari
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