2,928 research outputs found
Rozpor ako východisko, láska ako smer u Simone Weilovej (Contradiction as base, Love as direction in writings of Simone Weil)
No full textArticle is explaining contradiction and love, Simone Weil‘s essential terms of hermeneutics of human Being. It introduces close relation of these terms with her understanding of God as well as with her overall concept of religion. Author also mentions Simone Weil‘s inspirations with philosophical and spiritual concepts of the East
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells
No full textGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor and the current chemotherapeutic options for GBM are limited to temozolomide. Recently, inhibitors of kinesin spindle protein Eg5 have shown pronounced antitumor activity and our group has demonstrated that one of these inhibitors of kinesin Eg5, named K858, exerts important anti-proliferative and apoptotic effects on breast cancer cells. Since GBM cells usually express high levels of kinesin Eg5, we tested the effect of K858 on two human GBM cell lines (U-251 and U-87) and found that K858 could inhibit cell growth, induce apoptosis, revert epithelial-mesenchymal transition and inhibit migration in both cell lines. However, at the same time, K858 increased survivin expression, an anti-apoptotic molecule; so, down-regulating survivin with the specific inhibitor YM155, we obtained an important increase of K858-dependent apoptosis. This indicated that the anti-tumor activity of K858 on GBM was limited by the over-expression of survivin and that the negative regulation of this protein could sensitize tumor cells to K858-induced apoptosis. These data support the choice of kinesin Eg5 as target of new therapeutic approaches for GBM; in particular, K858 has been demonstrated to be a potent inhibitor of replication, inducer of apoptosis and negative regulator of the invasive phenotype for GBM cells
“I beg you to tell me what has become of Djamila”: The Political Mobilization of Simone de Beauvoir’s Readers During the Boupacha Affair
No full textBy Sophia Millman This is a condensed version of a Masters thesis dedicated to the political mobilization of Simone de Beauvoir’s readers. The citations from the letters were translated from French by the author. *** On June 2, 1960, the French government ordered all copies of the daily Algiers edition of Le Monde seized and destroyed to suppress the publication of Simone de Beauvoir’s article “Pour Djamila Boupacha.” Beauvoir, a self-professed “woman of letters”, not “of action[1]”, and one ..
A comparative study of form and theology in the works of Flannery O'Connor and Simone Weil
No full textIn this comparative study of the form and theology of Flannery O'Connor and Simone Weil I interrogate how Weil's philosophical writings and her theology illuminate O'Connor's use of both narrative and non-fictional forms, and her Catholicism. The Introduction analyses how Weil's concept of superposed reading provides a new method of approaching both O'Connor, her writings, and O'Connor
studies, and focuses on how such apparently different women interconnect. Chapter One explores how both Weil and O'Connor attempt to write their theologies on the
souls of their readers yet are each subject to constraints imposed by form. Weil's concept of locating equilibrium between incommensurates is discussed, and her
distinctively philosophical approach to fictions and fictionality is used to investigate O'Connor's notion of prophetic fictions and the writer's role. Chapter Two assesses how both writers revivify Christian paradoxes. Weil's monstrous concept of affiiction, and O'Connor's use of the grotesque genre to jolt secular man into an
awareness of the sacred are scrutinised. Chapter Three studies how both writers consider an encounter between God and man is possible through the action of grace. My Conclusion interrogates how Weil's work can deepen our understanding of O'Connor's writings, and examines how successful O'Connor is at realising a truly
Christian literature. I conclude that despite being a writer of powerful fictions, O'Connor can not be totally successful in her mission as writer-prophet because
ultimately fiction escapes orthodoxy
Tra manoscritti e libri della biblioteca di Elsa Morante: genesi e significati del Mondo salvato dai ragazzini
No full textThis thesis work stems from the intention to highlight one of Elsa Morante's least studied works: Il mondo salvato dai ragazzini (The World Saved by Kids). Published by Einaudi in 1968, it is probably the Roman writer’s most heterogeneous, multiform, and complex to interpret book. A first reason for the difficult collocation of this text lies in the impossibility of ascribing it to conventional categorisations of literary genre: it alternates between verse, prose, theatrical drama, visual poetry experiments, and non-semiotic codes of writing (staves, drawings) that make systematisation complex. A second reason can be traced back to the painful existential and writing phase Morante went through during the years of elaboration of the work, due to the problematic nature of her experiences: the death of her mother Imma Poggibonsi and lover Bill Morrow, a loss that marks the entire book, the controversial relationship with the hallucinogenic substances, alternately seen as a source of creativity and an impossible escape from a painful reality. Added to this is the traumatic clash with History and all the monstrous and sinister obscenities of the 20th century (the war, the Shoah, the consequences of autocratic capitalism) that, up to that point, seemed to be only the background of her narrative production. Moreover, it is necessary to consider the connection of The World saved by Kids, published in 1968, with the events of those years, so strong that Goffredo Fofi said that it is «the highest document of 1968 and its surroundings» (FOFI: 1969, 225) But although the references to the youth protest are quite explicit, the 1968 utopia becomes in Morante's work the embodiment of a more general revolutionary aspiration. The choral revolt of the Kids, the book’s protagonists and recipients, is indeed a meta-historical reality: a rebellion against social constraints, technocratic regimes, authoritarian thinking, ideological superstructures, and conceptual constraints that deprive young people, and poets, of their most authentic voice.
Chapter One describes the writer's personal and cultural journey in the years between 1964 and 1967, period of writing The World Saved by Kids, as reflected in various notations in the autograph papers that appear to be fundamental for the identification of a terminus post quem and ante quem within which to place the writing of the work. Through the analysis of the book’s main structural and formal features (internal subdivisions and overall architecture), the fundamental role that verse production plays in the literary and existential horizon of an author mostly known for her novels emerges. The second part of this chapter acts as a bridge to the next one: here, in fact, the discussion on the manuscripts and typescripts of The Word Saved by Kids is introduced through an analysis of Morante's writing practice: from the incessant labor limae that touches single words as well as entire sections of text to the structured planning of the arrangement of the archive material that appears almost already designed, in the author's intention, for readers' consultation.
In Chapter Two, an attempt is made to reconstruct the genetic-evolutionary path of the work through the consultation of autograph material conserved at the Biblioteca Nazionale Centrale di Roma in the Vittorio Emanuele 1622 and Archivi Raccolte e Carteggi 52 I 4.3 funds. Following the examination of the papers and the subsequent full transcription of the text contained therein, the main macroscopic changes to the entire work were identified (titles; subdivision into sections and subsections; deletion of entire parts). However, due to the dense layering of corrections in the papers, it was decided in the course of the work to include in the thesis all macro-textual considerations related to the book as a whole, but to restrict the philological analysis to a single section, The Chemical Comedy, which in turn comprises two lyric poems, a play and a long verse story divided into eleven compositions. This choice was motivated both by the central structural position of The Chemical Comedy, the junction point between the opening poem Farewell and the Folk Songs that close the volume, and by the complexity of its genesis. Indeed, it is the part of the book that has undergone, in the transition from the first draft to the final one, passing through numerous intermediate drafts, the greatest number of remakes, revisions and even aesthetic and substantial distortions. To follow the diachronic evolution of the text and to functionalise the philological discourse to a critical investigation of the book, it was therefore preferred to give a transcription of the verses, as transmitted by the papers in the most relevant editorial phases, and not to include a philological apparatus that would have hindered the readability of the study. However, to account for the frenetic movement of variants and to avoid transcribing uninteresting lessons because they are adiaphora or synonymous, the most notable microscopic variants have been selected in terms of stylistic or content changes and in relation to the communicative strategies adopted.
A second line of research has made it possible to combine the study of the antecedent with a timely survey of literary, philosophical and artistic suggestions inspired by ancient or contemporary works. Important, in this sense, are the paratextual sections that sometimes contain quotations, translations and references to the texts of other authors; however, the consultation of the volumes of the writer's personal library, today kept in the Fondo Morante of the Biblioteca Nazionale Centrale in Rome, has been fundamental. The numerous books are underlined, annotated, and often consumed by passionate and voracious reading; Morante's annotations therefore allow us to reflect on the intertextuality of a work that arises from a «dense weaving of references, borrowings, echoes and literary quotations». When identifying Morante's main cultural coordinates, however, the dynamic and multifaceted link that the author establishes with tradition has not been overlooked. Chapter Three traces, from the books in the library, an itinerary among the main models of the work, either textually displayed or only alluded to. The first authors referred to are the poets of the American beat counterculture, first and foremost Allen Ginsberg, who in those years inspired Morante in terms of experience, thematic choices, and language. There follows a section devoted to Greek tragedies and to some of the numerous readaptations and reinterpretations of classical myth in contemporary theatre, from Brecht to the Living Theatre: Morante recovers, combines, and rewrites them in the play at the centre of the book, The Evening at Colonus.
The essential core of this chapter is then the discussion of Morante's connection with Simone Weil's philosophy on the dual level of religious mysticism and ideological commitment. Beginning with the dense annotations found in the philosopher's books kept in Morante's library, Weil's thought is tackled from the perspective of an organic relationship with The World Saved by Kids, a work that turns out to be entirely built on the oscillation between the two Weilian poles of grâce and pesanteur. While the influence exerted by the French philosopher's meditations on Morante is undoubted, it is more interesting to highlight the profound convergences on the issues addressed by Weil. The last part of the chapter deals with the essay The End of the World: Cultural Apocalypse and Transcendence by the anthropologist Ernesto de Martino, a text that Morante possesses and comments on as evidenced by the reading marks in her edition. De Martino's considerations make it possible to identify a distinction between the representation of the cultural apocalypse in The World Saved by Kids and the psychopathological apocalypse in the latest novel Aracoeli; at the same time, they offer an interpretative key to discover new and dialoguing meanings in the interaction between the two works.
The Fourth Chapter takes up the results that emerged from the previous chapters and finalises them into an analysis of the book from the perspective of trauma studies. The aim is to propose a re-reading of the work as a narration in verse of individual and collective traumatic experiences, investigating the narrative devices and expressive choices made by the author to verbalise them. In this sense, the parts of the text that were not included in the final draft, the books read by the author, and the link with her models also help to shed light on the ellipses of a past and present that are traumatic on both a personal and historical level.
A two-part Appendix concludes the thesis. The first, which responds to the aim of reorganising and arranging the autograph papers in sequential order, contains an accurate description of the manuscript and typescript corpus: factual characteristics of the folios, collation, binding, presence of notes in the notebook plates, attachments. The second is intended to provide a schematic review of some of the books Morante frequented during the years of writing The Word Saved by Kids with a precise indication of the presence of any apostilles, reading marks and dedications. This work of cataloguing, of certain help to the critical discourse developed in the thesis, could also be preliminary to future studies that, based on the author's personal library, would contribute to a deeper knowledge of her human and cultural journey
Microlinices benthovus Simone 2014
No full textbenthovus, Microlinices Simone, 2014 Microlinices benthovus Simone, 2014: 575–578 (figs 6A–J, 7A–H, 11A–C). Gastropoda, Naticidae Paratypes (22 spc): MZSP 105269. Paratypes 1 (15 spc): MZSP 105270. Paratypes 2 (16 spc): MZSP 105271. Paratypes 3 (7 spc): MZSP 105272. Localities: Brazil, Espírito Santo, off Itaúnas, Abrolhos Slope, 18°59' S, 37°50' W, MD55 sta. DC 73, 637 m depth, 27 May 1987; 1) 19°00' S, 37°48' W, MD55 sta. DC72, 950– 1050 m, 27 May 1987; 2) off Regência, 19°40' S, 37°48' W, MD55 sta. CB77, 790– 940 m depth, 27 May 1987; 3) off Itaúnas, Abrolhos Slope, 19°01' S, 37°47' W, MD55 sta. CB79, 1500–1575 m depth, 28 May 1987. Collectors: P. Bouchet, J.H. Leal and B. Métivier. Preservation: Dry. Remarks: Former MNHN, Paris. The catalogue number MZSP 105250 is mentioned twice in Simone’s (2014) paper, among the paratypes of M. ibitingus Simone, 2014 and M. benthovus. This duplicity was a mistake by the author: the latter is an erroneous designation and should be disregarded. The only valid paratype lots for M. benthovus are the ones shown above.Published as part of Cavallari, Daniel C., Dornellas, Ana Paula S. & Simone, Luiz Ricardo L., 2016, Second annotated list of type specimens of molluscs deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil, pp. 1-59 in European Journal of Taxonomy 213 on page 10, DOI: 10.5852/ejt.2016.213, http://zenodo.org/record/384012
Was bringt die Föderalismusreform? Wahrscheinliche Effekte der geänderten Zustimmungspflicht
No full textThe recently enacted reform of German federalism is supposed to make legislation faster, more efficient and better. To what extent are these expectations justified? In order to assess the likely effects of the reform, this study uses a research design that was recently applied by the Research and Reference Services of the German Bundestag (parliament): we estimate the future effects of the reform by analyzing the impact it would have had on the legislation in the 14th and 15th term of the Bundestag if it had already been been in force at that time. In particular we ask: To what extent would the number of laws requiring the consent of the states' chamber, the Bundesrat, have been reduced? Which type of laws would have been affected by this reduction - the more controversial ones, or the less controversial ones? Which policy sectors would have seen the greatest reduction? How much would the reduction have increased the government's capacity to act effectively? Would the legislative process have been accelerated? -- Die verabschiedete Föderalismusreform soll die Gesetzgebung in Deutschland schneller, effizienter und besser machen. Inwiefern sind diese Erwartungen berechtigt? Zur Abschätzung der Reformfolgen auf die Bundesgesetzgebung folgen wir in dem vorliegenden Working Paper einer Vorgehensweise, die der Wissenschaftliche Dienst des Bundestages kürzlich in einer Studie angewandt hat: Die Auswirkungen der Föderalismusreform insbesondere auf die Zustimmungspflicht werden anhand der Gesetzgebung der 14. und 15. Legislaturperiode untersucht. Wir fragen insbesondere: Wie stark hätte sich der Anteil der Zustimmungsgesetze verringert, wenn die neuen Zustimmungsregeln schon in diesen beiden Legislaturperioden gegolten hätten? Wären eher zwischen Regierung strittige oder unstrittige Gesetze von der Zustimmungspflicht befreit worden? Welche Politikbereiche wären betroffen? Wie sehr hätte sich die politische Handlungsfreiheit der Bundesregierung erhöht? Wäre die Gesetzgebung durch die veränderten Zustimmungsregeln beschleunigt worden?
Numerical Behavior of Models of Composite Materials in E'NDT at 'Low' Frequencies
No full textIn this paperthe numerical modeling of composite materials in view of Nondestructive Testing is considered. The composite material is assumed to be modeled at the macroscopic scale by a possibly complex dielectric permittivity tensor. The material is probed by means of an electromagnetic field having wavelength much larger than the relevant geometrical dimensions. As well known, the numerical modeling is critical especially in this “low-frequency” regime where a strong ill-conditioning of the relevant stiffness matrix typically occur (the so-called low-frequency breakdown problem). The proposednumerical model is robust w.r.t. this underlying ill-conditioning
Idea ofiary u Simone Weil
No full textAutorka omawia ofiarę, jaką z samej siebie złożyła Simone Weil. Głównym celem autorki artykułu jest wykazanie, iż idea ofiary była najważniejszą myślą w życiu francuskiej filozof. W artykule ukazano myśl o ofierze w życiu i pismach intelektualistki, jak również analogie, które rzucają nowe światło na ofiarę Weil. Jako klucz do interpretacji i zrozumienia ofiary Weil, autorka analizuje myśl Emmanuela Levinasa oraz Józefa Tischnera.The author interprets the sacrifice that Simone Weil filed with itself. The main point of the present article is the assumption that the sacrifice Simone Weil was the most important idea of her life. A thought about the victim is portraying the article in the life and letters of the intellectual, as well as is portraying analogies which are shedding new light on the Weil victim. As the key to interpretation and understanding the her victim, the author is analysing the thought of Emmanuel Levinas and Jozef Tischner.Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00
My life on the road: the exhilarating experience of travel
No full textVERSION FRANÇAISE ICI By Tiphaine Martin Researcher at Babel, University of Toulon, Member of the editorial board of Simone de Beauvoir Studies and author of a doctoral dissertation about Simone de Beauvoir's travels Translated from French by Marine Rouch (under the kind supervision of her dear friend Daniel Sawyer) I will begin with a brief criticism of the French edition. While the translation is very pleasant and captures Gloria Steinem's fluidity, humor and appetite for life, there is no..
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