697 research outputs found
Cutting edge: a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs
No full textThe CD154/CD40 interaction is an important pathway of CD4 T cell help for CD8 T cell responses. In this study, we address the role of CD70, a member of the TNF superfamily and the ligand for the T cell costimulatory receptor CD27, in CD40-mediated priming of CD8 T cells. Using an agonistic anti-CD40 mAb to mimic the CD154/CD40 interaction we demonstrate that the priming of OT-I TCR transgenic or endogenous mouse OVA-specific CD8 T cells is critically dependent on CD70/CD27 interaction. CD70 blockade inhibited CD40-mediated clonal expansion of CD8 T cells and reduced the number of memory CD8 T cells generated. Furthermore, CD70 blockade during the initial priming of CD8 T cells inhibited the ability of memory CD8 T cells to expand in response to a second encounter with Ag. Our data indicate that CD70 expression on APCs plays a key role in CD40-dependent CD8 T cell responses
CD27 costimulation contributes substantially to the expansion of functional memory CD8+ T cells after peptide immunization
No full textNaive T cells require signals from multiple costimulatory receptors to acquire full effector function and differentiate to long-lived memory cells. The costimulatory receptor, CD27, is essential for optimal T-cell priming and memory differentiation in a variety of settings although whether CD27 is similarly required during memory CD8+ T-cell re-activation remains controversial. We have used OVA and anti-CD40 to establish a memory CD8+ T-cell population and report here that their secondary expansion, driven by peptide and anti-CD40, polyI:C or LPS requires CD27. Furthermore, antigenic peptide and a soluble form of the CD27 ligand, CD70 (sCD70), is sufficient for secondary memory CD8+ T-cell accumulation at multiple anatomical sites, dependent on CD80/86. Prior to boost, resting effector- and central-memory CD8+ T cells both expressed CD27 with greater expression on central memory cells. Nonetheless both populations upregulated CD27 after TCR engagement and accumulated in proportion after boosting with antigen and sCD70. Mechanistically, sCD70 increased the frequency of divided and cytolytic memory T cells, conferred resistance to apoptosis and enabled retardation of tumor growth in vivo. These data demonstrate the central role played by CD27/70 during secondary CD8+ T-cell activation to a peptide antigen, and identify sCD70 as an immunotherapeutic adjuvant for anti-tumor immunit
Correction to : Cost-Effectiveness of Parent–Child Interaction Therapy in Clinics versus Homes : Client, Provider, Administrator, and Overall Perspectives (Journal of Child and Family Studies, (2018), 27, 10, (3329-3344), 10.1007/s10826-018-1159-4)
No full textThe original version of this article unfortunately contained a mistake. The Author contributions section currently states: “A.F.: designed and conducted data analyses for this study, supervised by B.Y. with input by T.F. A.F. and T.F. assisted B.Y. in writing and revising the manuscript.” In fact, B.Y. and T.F. assisted A.F. in writing and revising the manuscript. Although T.F. and B.Y. were both involved in the writing, primary credit should go to A.F. (Alexis French, the first author). The authorship order above is accurate.</p
Review of the Monograph T.F. Khaidarov “Age of ‘Black Death’ in Golden Horde and Adjacent Regions” Kazan: Marjani Institute of History of Academy of Sciences, 2018. 304 P.
No full textThe author examines the monographic work of T.F. Khaidarov, devoted to the study of the second plague pandemic in the Golden Horde and neighboring territories, which was published in 2018. Researchers have already studied some aspects of the course of the Black Death in Eastern Europe. Before the publication of the monograph, T.F. Khaidarov had published several articles devoted to this problem. Despite this, the monograph is the first experience of a comprehensive study of the manifestations of the second plague pandemic in all their diversity in Eastern Europe. The objectives set in the book required the synthesis of various natural sciences (biology, climatology, medicine) and social (history, historical source study, social anthropology) disciplines. In the monograph phenomena of different scale are investigated. On the one hand, the epidemics in Eastern Europe were considered in the context of the worldwide course of the pandemic. On the other hand, from the researcher’s view did not escape the local phenomena: the specific dating of a particular outbreak of the epidemic, the problem of the perception of the disease by society, the features of its description, etc. In the review, an assessment is given to this "total" study of the pandemic. The advantage of this approach is that it overcomes the boundaries between different scientific disciplines, allows us to fill the knowledge that is fragmentary in each separate science. The drawback of this approach is that it leads to the absolutization of the plague factor in history. The study of Black Death becomes the main link in the whole multidisciplinary research, turns into a kind of paradigm. Sometimes this leads to incorrect reading of historical sources and scientific works. Despite the revealed shortcomings, it should be recognized that the monograph of T.F. Khaidarov is a serious step forward in the study of the problem at the present stage of the development of science
Effective Information Modelling Support
No full textElectrical Engineering, Mathematics and Computer Scienc
Fabrieksschema van de bereiding van styreen
No full textDocument(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
Is Foreign-Owned Capital a Bad Thing to Tax?
No full textThe aging population has raised at least two concerns about tax policy. First, taxes will need to be increased to cover higher public-pension and medical-care expenses when baby boomers have retired. Second, taxes can be cut in the meantime, as the government realizes the "fiscal dividend" that accompanies its debt reduction program (that has been motivated by the aging population development). This paper uses a simple endogenous growth analysis to examine these issues. It is assumed that sales tax increases are infeasible on political grounds. Two conclusions emerge: the income tax rate levied on domestic residents should be cut during the debt-reduction period, and the tax rate on foreigners whose capital is operating in Canada should be increased later on when the bulk of the baby boomers have retired.fiscal policy, endogenous growth, open economy
About the Educational Purposes of Literary Education
No full textThis article is devoted to educational component of the literary education, the author analyzes literature programs in this aspect (T.F. Kurdyumova, A.G. Kutuzov, V.G. Marantsman and many others). The author notes an encouraging trend towards understanding of education in literature classes as a subject-to- subject interaction, cooperation between students and teacher
Home Cooking, Food Consumption and Food Production among the Unemployed and Retired Households
No full textUtilizing the 1996 Canadian Food Expenditure survey matched with Canadian Nutrient File, we separate actual food consumption from observed expenditure and test the Permanent Income/Life Cycle Hypothesis on the true consumption data. We find that the lower food expenditure during periods of unemployment or retirement (previously reported in the literature), does not translate into poorer nutrition. Household calorie intake and major nutrient intake seem to be unaffected by changes in employment status. We find evidence that unemployed or retired households substitute food purchased from restaurants for food purchased for at home consumption. Further, with the 1998 Time Use Survey we find that individuals who are not employed devote more time for food preparation. Finally we present limited evidence that unemployed and retired households substitute precooked meals for meals made from primary ingredients.Food Production, Nutrition, Consumption Smoothing
A Note on Income Distribution and Growth
No full textMany analysts expect the aging population to lead to a reduction in the growth of living standards. Income inequality – a problem that has been accentuated by the payroll tax hikes that were necessary to fund the public pension as the population ages – is becoming an increasing challenge at the same time. As a result, policy-makers need to pursue initiatives that can simultaneously address both our efficiency and our equity objectives. With the challenge of the aging population, it is all the more important that we not rely on fiscal policies that involve a trade-off between growth and equality. This paper identifies a strategy for tax policy that meets these objectives.fiscal policy, endogenous growth, efficiency and equity
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