2,941 research outputs found
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Alive and Kicking! J.B. Priestley and the University of Bradford
No full textYesThis article explores the connections between Bradford-born author J.B. Priestley and the University of Bradford, using evidence from archives held in Special Collections at the University. The discussion includes the award of an honorary doctorate to Priestley in 1970 and the opening of the J.B. Priestley Library in 1975
NY 1870 Proposal
No full textSlide of a drawing in black and white from an unknown publication of an architectural proposal for a second story walkway between a four-story building with shops and a four-story hotel. The hotel reads: "Terrace Hotel" and the shops include Smiths, Rowe and Browne. Caption under the drawing reads: "View of terraced street, procuring more light and air, and greater safety against fire." Handwritten caption by J.B. Jackson reads: "NY 1870 Proposal"
Good Words (Magazine) for 1868
No full textAs Abbey writes, the fable articles here precede and are different from their first appearance in book form a year later. For it was then that Ralston published the first edition of Krilof and His Fables. See my comments on the third (1871) and fourth (1883) editions. The book smells of its many years! The three fable articles are on 39-46, including six illustrations on 40-41; 215-221, including six illustrations on 216-17; and 413-20, including six illustrations on 416-17. These are magazine articles. They comment on Krilof's views and particularly on Russian foibles. Thus one prose text after another is integrated into the article. In the book, there will be, after a preface and a memoir, a simple collection of texts. In fact, the selection of Krilof fables within the article here is excellent, and the author puts them into a good cultural and political context. At least some of the illustrations are the same as those in the third edition.. The texts are close to those found in the published books. It makes sense to see the texts in the magazine here as forerunners of those fable texts there. I presume that Ralston had opportunity to edit and amend between his magazine articles and his book's first edition. The publisher of the magazine is of course the publisher of the third edition that I have. The print is minuscule! I needed a magnifying glass for normal reading. The index just after 774 assigns J.B. Zwecker and A.B. Houghton as illustrators for the eighteen illustrations in the three fable articles. Dalziel, Houghton, and Zwecker are the names I can make out on the illustrations. Dalziel is not mentioned on the title page, but there is reference to others.This is a hardbound book (hard cover)Norman MacLeod; W.R.S. Ralston for fable
"J.B. Stoner", August 15, 1972
No full textPublic address written by John R. Lewis urging people to renounce the racially-repugnant sentiments of Georgia politician J.B. Stoner and register to vote in order to protect their interests, written August 15, 1972. 3 pages
Can Reynolds stress transport models be used for large eddy simulation?
No full textThis work explores a route to unify Reynolds averaged (RANS) and large eddy simulation (LES). The approach is to use a slightly modified Reynolds stress transport model for any mesh resolution. The model is formulated in terms of both total kinetic energy and modeled kinetic energy in such a way that the RST model correctly reproduces RANS results, LES results, and even DNS results (by turning itself off). The model equations do not contain functions of the mesh size within any of the model terms or constants. It is demonstrated that this approach works at any mesh resolution. In addition, the model naturally transitions between mesh resolutions, either coarse to fine or vice-versa. It is shown that for LES mesh resolutions the model returns a turbulent length scale that is proportional to the mesh size (the classic LES turbulent length scale)
The peripatetic fossils: part 4
No full textThese two articles are the latest round In exchanges over the charge that Professor VJ. Gupta is responsible for corruption of the palaeontological literature on the Himalayas. Gupta (p. 307) responds to the allegations of four co-authors of papers with him. Professor J.B. Waterhouse, another co-author, comments below both on those allegations and on the articles by Dr John Talent in which the issue was raised originally. Talent will reply in next week'sNature
Large deviations of planetary jets
No full textRare or extreme events are of great interest in climate and other systems. Few studies address these statistics from a dynamical perspective. Classical statistical approaches, for instance closures or stochastic averaging usually describe typical states or low order statistics only. Large deviation theory is a very interesting alternative to these classical methods. It can in principle describe both typical fluctuations and extreme fluctuations. This allows us to discuss the long time evolution of the jet. One goal is to predict the dynamics that may lead to change of regimes and change of attractors in atmospheric jet dynamics
Torrente Ballester's novel La saga/fuga de J.B. as a rehabilitation of imaginative prose
No full textWhen the novel La saga/fuga de J.B. (The Saga/Fugue of J.B.) came out in 1972, Gonzalo Torrente Ballester (1910-1999) had a long and extensive literary career behind him, but one which was marked by failures and the indifference of readers and critics. This novel, however, caused a sensation and was highlighted as Spain's answer to the Latin American "boom", as a proof that resourcefulness and unfettered imagination have their place in the Old World too… So although this was the author's magnum opus, which has naturally been the subject of a wide variety of studies and analyses, I think it has not been completely exhausted as a theme. In my work I attempt to perceive it not as a unique work of artistic creation by the author but also as the logical outcome of previous writing - it is this perception that I find lacking in the literature available on the novel and its author. For La Saga/fuga de J.B. contains constants in it which appear in a different form in Torrente Ballester's work from 1943, when he made his debut as a novelist with his book Javier Mario.Historia de una conversión/Javier Mario. The story of a conversion. And it also represents not only the result of many years of practical experience in writing novels but also the product of deep theoretical reflection on the genre. Torrente combines in..
Interactive processes in a Lanice conchilega (Annelida: Polychaeta) dominated intertidal community
No full textAn investigation was conducted into the factors influencing a soft-sediment intertidal benthic community dominated by the large tube building polychaete Lanice conchilega (Pallas, 1766). The environmental and biological characteristics of a mid-shore sampling site on a relatively sheltered sandflat were monitored over a two year period. A total of 115 taxa were recorded. Temporal variability in the community is discussed in relation to the sporadic occurrence of macroalgae, harsh winter conditions and physical disturbance to the sedimentary environment. Lanice conchilega had a significantly contagious distribution on the shore. The population was analysed using width measurements of both worms and tubes. Recruiting Lanice conchilega juveniles observed during the first year of the study were initially randomly distributed, but as these individuals developed the overall distribution of the population returned to being contagious. The presence of excess tubes towards the end of the sampling period indicated that individual Lanice conchilega were dying, being removed by predation or emigrating. Further sampling was designed to investigate the macrofauna and meiofauna in areas of sediment containing different densities of Lanice conchilega tubes. A consistently significant positive correlation existed between tube density and macrofaunal abundance, which was attributed to sediment-mediated interactions. At higher tube densities, an increase in the depth of sediment above the underlying clay equated to an increase in the volume of available infaunal space. In addition, Lanice conchilega-derived mucus and its associated microbes potentially enhanced levels of food resources available to deposit feeders. Species living at or near the sediment-water interface would also have been positively influenced by any sediment stabilisation in high tube density areas. Possible causes of a positive correlation observed between tube density and Exogone hebes abundance are discussed. No significant relationship existed between tube density and the abundance of macrofaunal juveniles, indicating that any inhibitory or facilitatory Lanice conchilega-juvenile interactions were either insignificant or acting in opposition to produce an overall neutral effect. Details of the developmental morphology of several polychaete species are described. Meiofaunal abundance (in particular nematode and harpacticoid abundance) was consistently greater in samples taken from areas of high tube density. Potential mechanisms responsible for this relationship include the provision of habitat heterogeneity and areas of refuge by tubes, and the enhancement of sediment stability and food resources by mucus. Particle accumulation in high tube density areas also potentially influenced meiofaunal settlement and resettlement patterns
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