162,589 research outputs found
Data for: Are Attitudes towards Emotions Associated with Depression? A Conceptual and Meta-Analytic Review
No full textthe raw file with our coding used to compute effect size
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Rottenberg_Supplemental_Material – Supplemental material for Optimal Well-Being After Major Depression
No full textSupplemental material, Rottenberg_Supplemental_Material for Optimal Well-Being After Major Depression by Jonathan Rottenberg, Andrew R. Devendorf, Vanessa Panaite, David J. Disabato and Todd B. Kashdan in Clinical Psychological Science</p
Cancer chess: molecular insights into PARP inhibitor resistance
No full textThe clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1 inhibition (PARPi). Despite spectacular initial responses in patients, resistance to PARPi treatment may develop and must be overcome to maximally exploit this interaction in the clinic. Genetically engineered (mouse) model systems have shown that PARPi resistance may arise through inactivation of the 53BP1 pathway. The 53BP1 pathway normally protects DSB ends from resection and the removal of this “brake” restores HR in the absence of BRCA1. However, how the 53BP1 pathway protects DSB ends from resection has remained elusive. In this thesis, advances in 3D tumor organoid culture protocols and CRISPR/Cas9 (screening) technology were applied to identify and validate new components of the 53BP1 pathway that render BRCA1 deficient cells resistant to PARPi upon their loss. Furthermore, a new acquired vulnerability that can be therapeutically exploited to deplete such PARPi resistant cells is described. Together, this thesis provides mechanistic insight in DSB repair and illustrates how such fundamental knowledge may stand at the basis to combat resistance.The research described in this thesis was performed at the Division of Molecular Pathology of the Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL) and Oncode Institute, Amsterdam, The Netherlands, and was financially supported by the Dutch Cancer Society (KWF 2011-5220 and 2014-6532 to S. Rottenberg and J. Jonkers), the Netherlands Organization for Scientific Research (VICI 91814643, NGI 93512009, Cancer Genomics Netherlands, and a National Roadmap Grant for Large-Scale Research Facilities to J. Jonkers), the Swiss National Science Foundation (310030_179360 to S. Rottenberg), the Swiss Cancer League (KLS-4282-08-2017 to S. Rottenberg); and the European Union (ERC CoG-681572 to S. Rottenberg and ERC Synergy Grant 319661 to J. Jonkers).Drug Delivery Technolog
Supplemental Material - Preclinical In-Vivo Safety of a Novel Thyrotropin-Releasing Hormone-Loaded Biodegradable Nanoparticles After Intranasal Administration in Rats and Primates
No full textSupplemental Material for Preclinical In-Vivo Safety of a Novel Thyrotropin-Releasing Hormone-Loaded Biodegradable Nanoparticles After Intranasal Administration in Rats and Primates by Yuval Ramot, Yakir Rottenberg, Abraham J. Domb, Michael J. Kubek, Kevin D. Williams and Abraham Nyska in International Journal of Toxicology</p
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Simon Rottenberg and Baseball, Then and Now: A 50th Anniversary Retrospective
No full textFifty years ago the JPE published Simon Rottenberg's "The Baseball Players' Labor Market", the first professional journal article in sports economics. In this retrospective we review some of his insights and analyses with regard to competitive balance, constraints on payroll and freedoms to contract, revenue sharing, territorial rights and the supply of talent. We also note subsequent industry developments Rottenberg could not have anticipated, and identify where he was ahead of his time.Rottenberg, baseball, invariance theorem, Coase theorem, reserve clause
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
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