371 research outputs found
I piccoli padiglioni universitari progettati da Enrico Mandolesi a Cagliari
No full textBetween 1962 and 1964, Enrico Mandolesi designed three small pavilions for the University of Cagliari: the Great Models Pavilion for the Institute of Construction 377 377 Antonello Sanna, Giuseppina Monni, Emanuela Quaquero I PICCOLI PADIGLIONI UNIVERSITARI PROGETTATI DA ENRICO MANDOLESI A CAGLIARI Science, the Pavilion for the Institute of Hydraulics and the Institute of Genetics. In all cases, the “pictorial” dimension, placing on the same level the warm tones of the clinker and the neutral one of the reinforced concrete, shows the author’s firm belief that all the materials have the same relevance. This is a lesson that Mandolesi learns from Mario Ridolfi, precursor of the Italian realism that abolishes the hierarchy between structural elements and finishes and declares that the creative idea of architecture lies in the precision of details. In the Great Models Pavilion for the Institute of Construction Science he chose to create a new volume connected to preexisting buildings with a small building. The horizontal and vertical windows declare the non-structural nature of the envelope made of bricks. A cultured design approach that uses the paradigm of the Illinois Institute of Technology by Mies van de Rohe. The Institute of Genetics is a building composed of two small volumes articulated on two levels and hinged to an independent stairway with a square plan. In this case, on a formal level, the basic principle is the horizontality that Mandolesi pursues at every level of detail. The author applied a combined solution that includes solid brick walls and a steel structure that connects to the frames of the fixtures. Both cases represent an accurate narration of construction stories that uses the combination of different materials, classic elements and modern solutions, the rough surfaces of reinforced concrete and the smooth ones of brick strips
“She Looks at Him with the Eyes of a Camera”: Female Visual Pleasures and the Polemic with Fetishism in Sally Potter’s Tango Lesson
No full textAuthor accepted manuscript version of an article published by Taylor & Francis in
Emanuela Guano (2004) She looks at him with the eyes of a camera: female visual pleasures and the polemic with fetishism in Sally Potter's Tango Lesson,Third Text, 18:5, 461-474, https://doi.org/10.1080/0952882042000251732.</p
Retouched pieces of la Fabbrica, Colle Rotondo and Castelcivita.
No full textRetouched pieces of la Fabbrica, Colle Rotondo and Castelcivita.</p
No changes in N-terminal pro-brain natriuretic peptide in a longitudinal cohort of patients with systemic sclerosis-associated pulmonary arterial hypertension on therapy with bosentan
No full textAbstract
AIM:
The aim of this study was to evaluate N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) and changes after therapy with bosentan.
METHOD:
Twenty-one patients with SSc-PAH on bosentan therapy were enrolled. PAH was diagnosed by right heart catheterization. NT-proBNP levels, 6-min walking test (6MWT), Doppler echocardiography to estimated systolic pulmonary arterial pressure (sPAP), New York Heart Association (NYHA) functional class for dyspnea and carbon monoxide lung diffusion capacity (DLco) were recorded at baseline, and after 1 and 2 years. Fifty-two SSc patients without PAH were also evaluated as controls.
RESULTS:
NT-proBNP plasma levels were significantly higher in SSc-PAH at 385 pg/mL (SD ± 427) than in SSc without PAH and 72 pg/mL (SD ± 52, P < 0.001) at baseline, but did not significantly change following bosentan therapy at 1 year (330 pg/mL [SD ± 291] and 2 years (374 pg/mL [SD ± 291]). However, NYHA class significantly improved at 2 years (P = 0.01) as well as 6MWT (P = 0.04). NT-proBNP levels were positively correlated only with sPAP but not with DLco, NYHA class or 6MWT.
CONCLUSIONS:
NT-proBNP levels were found to be significantly higher in SSc-PAH at baseline. Serial assessment of NT-proBNP in SSc-PAH patients on bosentan therapy showed no relation to the clinical improvement. This suggests that NT-proBNP may lack 'sensitivity to change', but further studies are warranted to assess the role of NT-proBNP as a biomarker of the therapeutic response in larger cohorts of SSc patients
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases
No full textThe gut–brain axis (GBA) is a complex interactive network linking the gut to the brain. It involves the bidirectional communication between the gastrointestinal and the central nervous system, mediated by endocrinological, immunological, and neural signals. Perturbations of the GBA have been reported in many neurodegenerative diseases, suggesting a possible role in disease pathogenesis, making it a potential therapeutic target. The gut microbiome is a pivotal component of the GBA, and alterations in its composition have been linked to GBA dysfunction and CNS inflammation and degeneration. The gut microbiome might influence the homeostasis of the central nervous system homeostasis through the modulation of the immune system and, more directly, the production of molecules and metabolites. Small clinical and preclinical trials, in which microbial composition was manipulated using dietary changes, fecal microbiome transplantation, and probiotic supplements, have provided promising outcomes. However, results are not always consistent, and large-scale randomized control trials are lacking. Here, we give an overview of how the gut microbiome influences the GBA and could contribute to disease pathogenesis in neurodegenerative diseases
Una bottega di artisti nel Veneto del Cinquecento: Antonio Rosso, Marco e Giovanni da Mel
No full textQuesta relazione riassume le principali conoscenze emerse dagli studi diagnostici di dipinti della bottega dei da Mel, condotta dal 2011 dal Laboratorio di Archeometria del Dipartimento di Fisica e Scienze della Terra dell’Università di Ferrara.
La bottega della famiglia da Mel era costituita da Antonio Rosso (ca.1455-1510), di origine cadorina, che si trasferì a Mel intorno al 1480 e dai fgli Giovanni (ca. 1480-1549) e Marco (1494-1583) e si dedicava prevalentemente alla tecnica dell’affresco. Numerosi infatti sono gli affreschi attribuiti alla bottega localizzati nelle valli della sponda orientale del Fiume Piave, come la chiesa di San Bartolomeo a Villapiana di Lentiai, dove si conserva un affresco attribuito a Marco da Mel.
Tuttavia Giovanni in particolare, grazie ai suoi numerosi viaggi e ai contatti che seppe intessere con Venezia, ebbe la possibilità di sperimentare anche altre tipologie di supporto. La grande pala d’altare, conservata nella chiesa di Trichiana, rappresenta l’unica tela a lui attribuita (1543), realizzata nell’ultima parte della sua vita.
Altri due dipinti su tavola, la pala di Bardiès e la Madonna con Bambino tra i Santi Rocco e Sebastiano della chiesa di Santa Maria Annunziata a Mel, sono esempi signifcativi dell’uso del supporto ligneo da parte dello stesso Giovanni da Mel.
Con l’uso delle diagnostiche scientifche, in maggioranza non invasive, su questi dipinti, si è inteso contribuire alla conoscenza dei materiali e delle tecniche pittoriche impiegate nell’artigianato artistico del Veneto della prima metà del Cinquecento
Rome and its domes. Drawing, art and architecture
No full textAny analysis performed to gather data about architectural and urban heritage always begins with the observation of reality and the involvement established between the observer and the space around them. A spectator inevitably interprets what they see in a personal manner so as to give objects a speci c meaning. The ability to understand the data and the relationship between the parts and then assign it a value varies from person to person. That the mind can mediate the mental processes of perception-action- thought means that any direct analysis to understand a cultural asset is scienti cally extremely important. The critical process sparked by an on-site study exploits the concise graphic transcription of what is visible, including the graphics tool used to achieve that representation. This contribution will present a study performed by the author to gather data using the drawings of several domes in the historical centre of the city of Rome
Spinoza muore
No full textThe Author presents the philosopher's theories on life, death, suicide and eternity of mind. The Author argues that the mind truly achieves a personal identity only in the dimension of eternit
Partial data on debitage at La Fabbrica, Colle Rotondo and Castelcivita.
No full textPartial data on debitage at La Fabbrica, Colle Rotondo and Castelcivita.</p
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