1,721,994 research outputs found
On the identity of Onthophagus columbianus Boucomont, 1932 (Coleoptera: Scarabaeidae: Scarabaeinae)
No full textRossini, M., Vaz-De-Mello, F. Z. (2016): On the identity of Onthophagus columbianus Boucomont, 1932 (Coleoptera: Scarabaeidae: Scarabaeinae). Zootaxa 4061 (3): 296-300, DOI: 10.11646/zootaxa.4061.3.1
Sarcoplasmic Reticulum-Mitochondria Kissing in Cardiomyocytes: Ca2+, ATP, and Undisclosed Secrets
Full text linkIn cardiomyocytes, to carry out cell contraction, the distribution, morphology, and dynamic interaction of different cellular organelles are tightly regulated. For instance, the repetitive close apposition between junctional sarcoplasmic reticulum (jSR) and specialized sarcolemma invaginations, called transverse-tubules (TTs), is essential for an efficient excitation-contraction coupling (ECC). Upon an action potential, Ca2+ microdomains, generated in synchrony at the interface between TTs and jSR, underlie the prompt increase in cytosolic Ca2+ concentration, ultimately responsible for cell contraction during systole. This process requires a considerable amount of energy and the active participation of mitochondria, which encompass ∼30% of the cell volume and represent the major source of ATP in the heart. Importantly, in adult cardiomyocytes, mitochondria are distributed in a highly orderly fashion and strategically juxtaposed with SR. By taking advantage of the vicinity to Ca2+ releasing sites, they take up Ca2+ and modulate ATP synthesis according to the specific cardiac workload. Interestingly, with respect to SR, a biased, polarized positioning of mitochondrial Ca2+ uptake/efflux machineries has been reported, hinting the importance of a strictly regulated mitochondrial Ca2+ handling for heart activity. This notion, however, has been questioned by the observation that, in some mouse models, the deficiency of specific molecules, modulating mitochondrial Ca2+ dynamics, triggers non-obvious cardiac phenotypes. This review will briefly summarize the physiological significance of SR-mitochondria apposition in cardiomyocytes, as well as the pathological consequences of an altered organelle communication, focusing on Ca2+ signaling. We will discuss ongoing debates and propose future research directions
Case study on simulation analysis of a logistics network with multiple products by applying lateral transshipments algorithms
No full textPurpose The purpose of this paper is to develop a simulation model to evaluate inventory and distribution decisions like lateral transshipments in a network with multiple products. Design/methodology/approach Data are collected from a company, and a discrete-event simulation in Python is developed to support the decision-making process of managers through different algorithms of lateral transshipments. Findings The numerical results show that the periodic delivery-continuous reorder policy is more robust than the others because the reorder process is not affected by the higher saturation that is achieved by periodic reorder-based policies. The new lateral transshipment algorithm will lead to huge savings in logistics costs for any company and increase truck saturation without causing a decrease in the service level. Research limitations/implications This paper provides a novel institutional perspective on a complex logistics issue where COVD-19 is believed to complicate the context. Practical implications This solution is devised for any company to achieve even greater benefits in terms of customer service improvement and logistics costs reduction. Originality/value The main contribution of this paper is the proposal of a new lateral transshipment algorithm that shows performance improvement by simulating distribution network processes according to different configurations
FIGURE 1. A–C. O in On the identity of Onthophagus columbianus Boucomont, 1932 (Coleoptera: Scarabaeidae: Scarabaeinae)
No full textFIGURE 1. A–C. O. elegans: dorsal habitus of the lectotype (A) and one paralectotype (B). Lectotype labels (C).Published as part of Rossini, M. & Vaz-De-Mello, F. Z., 2016, On the identity of Onthophagus columbianus Boucomont, 1932 (Coleoptera: Scarabaeidae: Scarabaeinae), pp. 296-300 in Zootaxa 4061 (3) on page 298, DOI: 10.11646/zootaxa.4061.3.10, http://zenodo.org/record/25571
Monoclonal immunoglobin deposition disease, heavy chain deposition type
No full textno abstract availabl
Mechanisms leading to progression of chronic renal injury: The interstitium
No full textProgressive renal regardless of the initiating insult, is characterized by glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. The severity of the tubulointerstitial fibrosis closely parallels the decline in renal function. Primary mechanisms of progressive scarring of the tubulointerstitium include up-regulated tubular expression of cytokines and extracellular matrix, adverse consequences of infiltrating macrophages, and possible epithelial-mesenchymal transdifferentiation, resulting in a profibrotic interstitial infiltrate. Better understanding of the mechanisms involved the potential to result in the recognition of new targets for pharmacologie interventions. © 2004 Elsevier Ltd. All rights reserved
Interpreting segmental glomerular sclerosis
No full textThe term 'focal segmental glomerulosclerosis' (FSGS) is used to describe the common morphologic lesion underlying various progressive renal diseases and also to describe the clinical syndrome with occurrence of the primary idiopathic lesion of focal segmental glomerulosclerosis. Different morphological patterns of focal segmental glomerulosclerosis are associated with different processes, reflecting the presence of diverse pathogenic mechanisms leading to focal sclerosis. The diagnosis of FSGS rests first on the recognition of segmentally sclerotic glomeruti, and then on specific morphologic features to distinguish the various types of FSGS. Five main light microscopic patterns of FSGS have been defined by the Columbia Consensus Classification of FSGS. Some of these patterns may be also observed in some secondary forms of FSGS. The location of sclerosis and the recognition of particular light microscopic patterns, immunofluorescence and electron microscopy findings can provide important information about the aetiology and prognosis of the lesion. © 2003 Published by Elsevier Ltd
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