186,214 research outputs found

    Comparison of response surface methodology and the Nelder and Mead simplex method for optimization in microsimulation models

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    Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface Methodology and the Nelder and Mead Simplex Method for optimization of microsimulation models. To this end, we tested several automated versions of both methods on a small microsimulation model, as well as on a standard set of test functions. With respect to accuracy, Response Surface Methodology performed better in case of optimization of the microsimulation model, whereas the results for the test functions were rather variable. The Nelder and Mead Simplex Method performed more efficiently than Response Surface Methodology, both for the microsimulation model and the test functions.health;simulation;optimization

    Bryant, R M (Robert Mead), VX66457

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/374413Surname: BRYANT Given Name(s) or Initials: R M (ROBERT MEAD) Military Service Number or Last Known Location: VX66457 Missing, Wounded and Prisoner of War Enquiry Card Index Number: 15064185788 Item: [2016.0049.06721] "Bryant, R M (Robert Mead), VX66457

    Becoming Mead: Sammelrezension zu Daniel R. Huebner und George Herbert Mead

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    Sammelrezension: 1) Daniel R. Huebner: Becoming Mead - The Social Process of Academic Knowledge. Chicago and London 2014. ISBN 9780226171401. 2) George Herbert Mead: Mind, Self, & Society - The Definitive Edition. Edited by Charles W. Morris, Annotated Edition by Daniel R. Huebner and Hans Joas. Chicago and London 2015. ISBN 978022611273

    James R. Mead, an early pioneer

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    Thesis (M.A.)-- University of Wichita, College of Liberal Arts and Sciences, Dept. of HistoryThis work is to tell of one of the pathfinders and pioneers who blased the path of civilization through the region called the "great American Desert" . Mr. James R. Mead was one of the outstanding leaders in the opening of the central part of Kansas. Many parts of the country which were hitherto unknown were explored by him and became the homes of countless numbers of sturdy farmers.Preface -- Table of contents -- Frontispiece -- Mr. Mead's Ranch at Towanda -- Map -- Introduction -- Early life of James R. Mead -- Exploration of Saline River -- The drought of 1860 -- First home in Kansas -- Founding a home in Butler County -- Experiences on the Little and Big Arkansas -- A winter's hunt -- Life and industry along the Arkansas River in the early 60's -- Mr. Mead in Kansas history -- Bibliographical note -- Bibliograph

    Statistical Principles for the Design of Experiments

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    This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication

    Interview with Carver A. Mead

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    An interview in July 1996 with Carver Andress Mead, Gordon and Betty Moore Professor of Engineering and Applied Science (as of 1999, Moore Professor emeritus). Dr. Mead received his undergraduate and graduate education at Caltech (BS, 1956; MS, 1957; PhD, 1960). He joined the Caltech faculty in 1958, becoming a full professor in 1967. In this interview, he recalls growing up in the mountains east of Fresno, father's work for the Southern California Edison Company; early education in a one-room schoolhouse, then high school in Fresno. Early interest in electronics. Enters Caltech in 1952. Freshman courses with Linus Pauling, Richard Feynman, Frederic Bohnenblust; junior year focuses on electrical engineering. Stays on for a master's degree with the encouragement of Hardy C. Martel. PhD student with R. David Middlebrook and Robert V. Langmuir. Work on electron tunneling; grants from the Office of Naval Research and General Electric. Helps establish applied physics in the 1960s with Amnon Yariv and Charles Wilts. Discusses his friendship with Gordon Moore and work on design of semiconductors. Discusses the establishment of a computer science department at Caltech in the mid-1970s and the arrival of Ivan Sutherland: the Silicon Structures Project. Departure of Sutherland in 1978 and decline of computer science under Pres. Marvin L. (Murph) Goldberger. MOSIS [Metal Oxide Semiconductor Implementation Service] program. Teaching at Bell Labs, 1980; startup of fabless semiconductor companies. Discussion of Caltech's attitudes toward investment in small technology companies and licensing arrangements. His own consulting for Silicon Valley companies. MESFET [Metal Semiconductor Field Effect Transistor]. Formation of CNS [Computation and Neural Systems] program at Caltech with John Hopfield, early 1980s. Caltech's Center for Neuromorphic Systems Engineering; help from National Science Foundation; involvement of Christof Koch, Demetri Psaltis, Rodney M. Goodman, Pietro Perona, and Yaser Abu-Mostafa. The interview concludes with a discussion of his interest in the freshman and sophomore physics courses and his advocacy of greater flexibility in the curriculum
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