64 research outputs found
Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems
No full textCopyright @ 2013 The authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.The use of human and veterinary pharmaceuticals is increasing. Over the past decade, there has been a proliferation of research into potential environmental impacts of pharmaceuticals in the environment. A Royal Society-supported seminar brought together experts from diverse scientific fields to discuss the risks posed by pharmaceuticals to wildlife. Recent analytical advances have revealed that pharmaceuticals are entering habitats via water, sewage, manure and animal carcases, and dispersing through food chains. Pharmaceuticals are designed to alter physiology at low doses and so can be particularly potent contaminants. The near extinction of Asian vultures following exposure to diclofenac is the key example where exposure to a pharmaceutical caused a population-level impact on non-target wildlife. However, more subtle changes to behaviour and physiology are rarely studied and poorly understood. Grand challenges for the future include developing more realistic exposure assessments for wildlife, assessing the impacts of mixtures of pharmaceuticals in combination with other environmental stressors and estimating the risks from pharmaceutical manufacturing and usage in developing countries. We concluded that an integration of diverse approaches is required to predict 'unexpected' risks; specifically, ecologically relevant, often long-term and non-lethal, consequences of pharmaceuticals in the environment for wildlife and ecosystems
The choral foundation of Durham Cathedral, c.1350 - c.1650
No full textThe muniments of Durham cathedral, city, and diocese have been explored in order to present and assess the contribution made by lay musicians to worship in the cathedral. By 1335-60 the boys and men had become sufficiently established to merit specific payments. Whether or not the lay Cantor dates back that far is uncertain, but in 1390 it was agreed that what was required was a Cantor-Instructor. No proof for the implementation of this earlier than 1415 has come to light, nor has any contract earlier than that made by the monastery with John steel in 1430. From it and those of his successors, and from Rites of Durham, a picture emerges of the Cantor's duties and of the part played by boys and men in the daily Lady Mass in the Galilee chapel and in the Mass of the Name of Jesus on Fridays in the nave. Following the suppression of its monastic arm in 1539 Durham was re-constituted a cathedral only in 1541 . The pattern of worship established c.1560 continued until the 1620s, when the innovations introduced by John Cosin caused Peter Smart (a Calvinist) to preach a vituperative sermon on 27 July 1628. From the litigation which ensued much emerges about whole ordering of worship in Durham since the 1560s. Produced whilst the ceremonialists held sway were several sets of new music books for the choir. Some 40% of these are still in Durham. such is the detail in the muniments that it has proved possible to suggest when the books were transcribed and by whom. It has also proved possible to identify the contributions of no fewer than eight Durham scribes to the music books at Peterhouse, Cambridge. That their work should be so far afield is explained by the fact that when John Cosin became Master of Peterhouse i n 1635 he re-established the post of College organist and drew heavily upon the Durham repertoire. The succession of Cantors and Masters of the Choristers provided the framework on which to interweave details of their lives, historical events and musical developments. Biographical information relating to the other members of the choir has been assembled in Appendix 1. This is followed other Appendices many of which present together all occurrences of certain fields of information
The life and death of laboratory teaching of medical physiology: a personal narrative. Part I.
No full text Part I of this essay sketches the history of laboratory teaching of medical physiology in England from the perspective of the author as a student at Oxford from 1935 to 1938. The systematic laboratory teaching that began in the 1870s at University College London under William Sharpey was carried to Oxford, as well as to other English and Scottish universities, by Sharpey's junior colleagues. C. S. Sherrington added mammalian experiments, and C. G. Douglas and J. G. Priestley added experiments on human subjects. The author describes his experience as a student in the Oxford courses and tells how he learned physiology by teaching it from 1941 to 1943 in the laboratory course established at the University of Pennsylvania by Oxford-trained physiologist Cuthbert Bazett. </jats:p
The Church of Christ in early Bernicia: forerunners and foundation
No full textA firmly multidlsciplinary approach starts from a theological definition of the Church as the Body of Christ, and Christians as empowered by the Holy Spirit, the possibility of miracle, and the reality of warfare with demons are taken seriously, and scholarly belief in them defended. They are made the subject of excursuses. Hagiographic writings are treated with cautious respect. Bernicia, land and people, and its relationship to its neighbours are considered. In a demographic excursus the view that Dark Age life-span was short is rebuffed. Part two discusses the life and mission of the Church in sub-Roman Britain. In our area evidence for this proves to be largely limited to the shadowy activities of Ninian and Kentigern, therefore further evidence of the status of the British church in the fifth and sixth centuries is sought in Patrick’s Confession and Gildas's De Excidlo Britɸmniae. A new model for the latter - the sermon of the protomartyr Stephen - is proposed; as is a new exegesis of D. E. B. c.69, which may have Implications for our understanding of the persistence of Pelagian beliefs. An excursus considers the significance of white stones in association with Christian burial. The origins of the mission of Augustine are considered briefly. Part three considers the mission of Paulinus in detail, in particular the reasons for its collapse; in contrasting it with the Celtic mission misslological principles are cited. A reappraisal of Paulinus's retreat, more favourable to him than that normally held, is reached by invoking wartime experience. The discipline of obstetrics is involved to advance the theory that /Ethelburh's delivery was premature; also earlier to re-examine the Herbert Ian account of Kentigern's conception, where the 'something contrary to sound doctrine' is identified, against the hitherto standard view, as the apparent approval, by Servanus, of extramarital coitus. The final establishment of the Church in Bernicia is seen as occurring principally as the result of Aidan's mission, but with valid contributions from the British and Roman traditions. That Simeon of Durham gave the credit for this foundation to Oswald is found Justifiable. A new genealogical tree of Oswy has been constructed, and maps have been provided
HASS PhD graduate careers and knowledge transfer: A conduit for enduring, multi-sector networks
No full text© The Author(s) 2019. Rising worldwide scrutiny of the PhD has focused on issues such as return on investment and career outcomes. This article investigates PhD graduate careers and knowledge transfer looking at the Humanities, Arts and Social Sciences (HASS). Firstly, our extensive literature review of PhD graduate outcomes reveals limited knowledge of HASS careers and a Science, Technology, Engineering and Mathematics (STEM) bias. Secondly, our case study of graduates suggests HASS PhDs provide a vital conduit for end-user engagement and knowledge transfer. Our findings deepen knowledge about the careers of HASS PhDs by revealing pre-existing professional networks may be harnessed to inform end-user relationships throughout candidature and post-graduation. Contrary to dominant assumptions, these networks may endure even for graduates in the academy. This under-recognized phenomenon demonstrates the multi-sector knowledge transfer capacity of HASS researchers with implications for their research capability and career development needs and perceptions of the value of their research
Change in Northumbria : was Aldfrith of Northumbria's reign a period of innovation or did it merely reflect the development of processes already underway in the late seventh century?
No full textThis thesis looks at a period of Northumbrian history when the king was a part Irish, Iona trained scholar. Some have suggested that Aldfrith was assisted to the kingship by the northern victors of the battle of Nechtansmere. It examines processes in the late seventh century to try to identify changes that might have happened during the reign of this king.
The study begins with a wide overview of previous research to establish a basis from which to look for processes and change and also examines the sources available to us, written and archaeological. It then looks at the kingdoms to the north and west and at Aldfrith and the period of his reign. The suggestion is made that Aldfrith acted, with the Church, to cult saints that were Northumbrian and Romanist, as opposed to other options that might have been available. It proposes that the Northumbrians rejected opportunities to develop links with the north and west that may have been open to them. The following chapters then examine processes underway in Northumbria in three general areas; in the use of power, in society, and in the economy.
It concludes that although many processes continued as before, these sped up and in certain areas such as the production of coins, and the consequential development of trade, it was a period of innovation. There is no evidence of a focus to the north and west during Aldfrith’s reign and this has implications for how Aldfrith got to the throne, suggesting that it was with the support of the Northumbrian elite and not through the military strength of the Dál Riata or the Picts. The evidence is that Northumbria increasingly looked south for its influences and is prepared to absorb and implement processes and approaches from southern England, Gaul and Rome
Notes on Three Northern English Quietists
No full textThe author here extends a dialogue with Jeffrey M. Perl, published in the Spring 2010 issue of Common Knowledge, under the title “`Decorate the Dungeon.'” That dialogue concerns whether Thomas More could have avoided martyrdom though he acted with heroic quietism during the Henrician Reformation. Dubious of this premise during the previous exchange, the author here examines the lives of three northern English quietists of More's time—Christopher Urswick (c. 1448–1552), Cuthbert Tunstall (1474–1559), and John Redman (1499–1551)—who never quite risked martyrdom but never abandoned their own principles either. This essay concludes that Tunstall was the most heroic of the three. As a bishop (for well over thirty years), he could have burned heretics in the 1530s and 1550s but he sent no one to death—a record perhaps better than that of Thomas More, who saw sedition in some of those brought before him as heretics when he was chancellor. A record so free of violent commitment as Tunstall's was extraordinary in his time, as in ours, and this article gives it due recognition.</jats:p
Processes in continental collision zones: Preface
No full textFormation and exhumation of high-pressure (HP) to ultrahigh-pressure (UHP) metamorphic rocks in continental subduction zones are the two fundamental geodynamic aspects of collisional orogensis. This volume is based on the Session 08c titled "Geochemical processes in continental collision zones" at Goldschmidt 2010 in Knoxville, USA. It focuses on micro- to macro-scale processes that are temporally and spatially linked to different depths of crustal subduction/exhumation and associated mineralogical changes. They are a key to understanding a wide spectrum of phenomena, involving HP/UHP metamorphism and syn-/post-collisional magmatism. Papers in this volume report progresses in petrological, geochronological and geochemical studies of UHP metamorphic rocks and their derivatives in China, with tectonic settings varying from arc-continent collision to continent-continent collision. Microbeam in-situ analyses of metamorphic and magmatic minerals are successfully utilized to solve various problems in the study of continental deep subduction and UHP metamorphism. In addition to their geochronological applications to dating of HP to UHP metamorphic events during continental collision, microbeam techniques have also served as an efficient means to recognize different generations of mineral growth during continental subduction-zone metamorphism. Furthermore, metamorphic dehydration and partial melting of UHP metamorphic rocks during subduction and exhumation are highlighted with respect to their effects on fluid action and element mobilization. These have provided new insights into chemical geodynamics in continental subduction zones. (C) 2011 Elsevier B.V. All rights reserved.Geochemistry & GeophysicsMineralogySCI(E)0EDITORIAL MATERIAL,SI1-913
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