1,721,276 research outputs found
Collection and transfer of data: the AIEOP model
No full textAdvanced Multicenter Research (AMR) is a Web-based information technology infrastructure, fully integrated to manage every single part of a clinical trial, but with 'independent' and 'customizable' components to wholly meet each team's requirements. The AIEOP group utilizes AMR for the management and analyses of the majority of the expected nationwide oncology cases and the most common primary immunodeficiencies, and for all the AIEOP protocols, studies and registries centralized at the AIEOP Operation Office. Standard for data quality control is applied to each AIEOP database according to the AMR standard procedures. The AMR AIEOP network represents a model of Information Based Medicine, a crucial tool for well-informed pediatricians, essential to guarantee better childcare in a setting of patients such as children with cancer
Current use and outcome of blood and marrow transplantation in childhood according to the italian registry.
No full textSince 1985 data concerning patients affected by malignant and non-malignant diseases, aged <17 years, grafted in 16 centers nationwide, have been collected and stored in a central data base organized at the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP) Operation Office within the AIEOP BMT Registry. The information, collected and structurally integrated with other specific disease-oriented national data bases, permitted the elaboration and the following publication of several analyses on survival, relapse probability and transplant-related mortality for the different diseases
The challenge of pooling national registries in paediatric bone marrow transplantation
No full textno abstrac
Segnalazione di un nuovo ittiosauro dal Cretaceo dell’Appennino modenese (Pavullo nel Frignano)
Full text linkAlcuni frammenti vertebrali di ittiosauro sono stati recentemente rinvenuti in un calanco presso Pa- vullo nel Frignano (MO). I fossili sono stati trovati entro la Formazione delle Argille Varicolori di Cassio, datate al Cenomaniano superiore-Campaniano (Cretaceo). Tra i reperti rinvenuti è impor- tante segnalare un tratto di colonna vertebrale ancora parzialmente articolata. Si tratta del primo ritrovamento di questo tipo in Italia per quanto riguarda gli ittiosauri del Cretaceo. Alcuni dei corpi vertebrali in oggetto sono di dimensioni relativamente grandi, paragonabili a quelle già note per alcune specie di Platypterygiinae quali Platypterygius australis e P. americanus.Some vertebral fragments of ichthyosaur have recently been found in a clay badland near Pavullo nel Frignano (Modena Province). The finds were discovered in the “Argille Varicolori di Cassio” Formation, which dates from the upper Cenomanian-Campanian (Cretaceous). Among the fossils recovered, a portion of vertebral column, still partially articulated, is of outstanding importance. This is the first discovery of an articulated portion of a skeleton of a Cretaceous ichthyosaur in Italy. Some of the centra are relatively large, comparable to those already known for some species of Platypterygiinae such as Platypterygius australis and P. americanus
Moving towards Information Based Medicine in pediatric oncology
No full textPediatric oncologists have achieved commendable success in recent decades, especially with the help of multicentric research. Information Based Medicine is a model of individualized healthcare whereby patients receive specific treatment solutions, targeted to their specific disease states and their genetic and metabolic profiles, in order to ensure the best probability of recovery with the best short and long term quality of life (QL). From the patient's perspective, moving towards Information Based Medicine entails the storage, integration, and analysis of the data from various sources in nationwide networking systems. The final goal of Information-Based Medicine is to provide the right information in the right format to the right individual at the right time, and the Italian Association for Pediatric Hematology Oncology group is moving towards an era accustomed to Information Based Paediatric Oncology
A multidisciplinary approach in recognizing seep-carbonates: A case study from the Loiano Formation (late Eocene) in the northern Apennines (Italy)
No full textAutologous versus allogeneic BMT in AML: the European experience. Report of the EBMT--Pediatric Diseases Working Party.
No full textThe Austrian-German-Italian (AGI) Pediatric Bone Marrow Transplantation Registry includes now data of 520 patients grafted for acute myeloid leukemia (AML) by autologous and allogeneic stem cells. In first complete remission (CR1) 145 patients with allografts had a possibility of event free survival (pEFS) of 0.57 and 140 patients with autografts a pEFS of 0.46. In second complete remission (CR2) autografted patients (n = 70) had a pEFS of 0.36 and allogeneic patients (n = 41) of 0.34. Patients with no CR went worse (allogeneic pEFS 0.15 n = 37; autologous pEFS 0.17 n = 6). Therefore, from the European data the following conclusions can be drawn: neither in CR1 nor in CR2 any statistical advantage for a particular transplantation type can be found. To assess the value of transplantation with family mismatch donors or matched unrelated donors (MUD) basing on these data pool is not possible. The following decisions should be reached: 1) BMT for AML with mismatched or unrelated donors should be done only within cooperative European trials. 2) Generally accepted definitions of indications for BMT in AML are needed. 3) Study protocols concerning conditioning are necessary
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