1,720,973 research outputs found
Increased serum activity of lactate dehydrogenase in infants with necrotizing enterocolitis: a potential marker of advanced disease
No full textAsphyxiated neonates have an increased serum activity of selected enzymes. Since hypoxia/ischaemia is a pathogenetic factor for necrotising enterocolitis (NEC), the serum activity of these enzymes may also be increased in infants with NEC. Our aim was to evaluate whether the serum activity of selected enzymes was increased in patients with NEC, particularly those with advanced disease. A retrospective review of all infants treated for NEC between 1998 and 2006 was undertaken. Patients with suspected NEC or focal intestinal perforation were excluded. Patients with definite (group A) and advanced (group B) NEC and a determination of serum activity of alkaline phosphatase, creatinine kinase, glutamic oxaloacetic transaminase and lactate dehydrogenase were included in the study. Maximum serum activity during the course of the disease was determined and compared in the two groups by the Mann–Whitney test. Thirty-seven infants with definite (24) or advanced (13) NEC had a determination of serum enzymes activity at some stage of their disease. Group B patients had significantly higher activity of lactate dehydrogenase (p < 0.05) and a trend towards higher creatinine kinase activity. The serum activity of selected enzymes may thus be increased in infants with advanced NEC. Evaluation of this parameter could be an additional tool in the surgical decision-making process in infants with this disease
High serum enzyme activities in neonates with intestinal obstruction indicate bowel necrosis
No full textCannula tip intravascular migration in an infant
No full textIn infants, the tip of a cannula is sometimes used as introducer during
peripherally inserted central catheters placement. We report a rare complication
of this procedure, characterized by intravascular migration of the cannula tip
during peripheral insertion of a central venous catheter. We review this unlikely
complication and treatment options
Il ruolo degli enzimi sierici per la diagnostica nei neonati affetti da occlusione intestinale congenita
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Hearing impairment in congenital diaphragmatic hernia: the inaudible and noiseless foot of time
No full textAIM OF THE STUDY: Infants with congenital diaphragmatic hernia (CDH) are at high
risk of sensorineural hearing loss (SNHL). Extracorporeal membrane oxygenation is
known to increase this risk, but little is known about other potential causes. We
evaluated the impact of several risk factors on SNHL development in CDH survivors
not treated with extracorporeal membrane oxygenation.
METHODS: All high-risk CDH survivors consecutively treated between 1999 and 2005
were included. SNHL was diagnosed based on formal assessment with standard
audiologic tests. Patients with and without SNHL were compared for
patient-related and treatment-related risk factors. Subsequently, a logistic
regression analysis was performed to identify independent risk factors associated
with SNHL development.
MAIN RESULTS: Out of 87 CDH survivors, 82 had a formal audiologic evaluation and
40 (49%) had SNHL. Patients with SNHL had significantly lower gestational age (P
= .045); higher prevalence of sepsis (P < .001); older age at audiologic
examination (P < .001); more episodes of hypocapnia (P = .045); higher prevalence
of inhaled nitric oxide use (P = .005); longer mechanical ventilation (P = .009);
and longer aminoglycosides (P = .006), furosemide (P = .004), and pancuronium
bromide (P = .001) treatments. On logistic regression analysis, the only variable
independently associated with the development of SNHL was patient's age at
audiologic follow-up (P = .012).
CONCLUSIONS: Several risk factors were associated with SNHL development at
univariate analysis. After logistic regression, only age at evaluation remained
independently associated with SNHL. Routine audiologic follow-up is advocated in
all CDH patients. Further studies are needed to define if other (genetic) factors
may be involved in the pathogenesis of SNHL in patients with CDH
La lattico deidrogenasi sierica è aumentata nei pazienti affetti da enterocolite necrotizzante avanzata
No full textHearing impariment in congenital diaphragmatic hernia: the inaudibile and noiseless foot of time
No full textMortalità nell'ernia diaframmatica congenita: euforia, depressione o è solo l'impatto della selezione dei pazienti?
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