218 research outputs found
Enoxaparin versus warfarin for prevention of deep vein thrombosis following total hip replacement
No full textBernie J. O'Brien, David Anderson, Ron Goeree. --Bibliography: leaves 19-22
Zandsuppletie op het strand van de Kop van Goeree, uitgevoerd met behulp van de zogenaamde "Punaise"
No full textEr is naar potentiële wingebieden gezocht, waar de punaise in principe kan worden ingezet. Deze wingebieden moesten binnen een afstand van 10 km van de Kop van Goeree liggen, omdat verwacht wordt, dat de uitvoering met de punaise tot die afstand nog concurrerend is met een conventionele uitvoering. Tevens moesten de wingebieden van nature aanzanden, zodat de inzet van de punaise de zandbewegingen in het kustgebied van Goeree zo min mogelijk zou verstoren en dit zo min mogelijk nadelige gevolgen voor de kust zou hebben. Dit onderzoek leverde vier mogelijke wingebieden op. De werkomstandigheden in de wingebieden zijn vergeleken, zodat een voorkeur voor één van de wingebieden kon worden uitgesproken. Om echter een verantwoorde keuze te doen is onder andere een gedetailleerd grondonderzoek noodzakelijk. Dat gaat de mogelijkheden van dit afstudeerrapport echter te boven. Voor het gekozen wingebied is een berekening gemaakt van de aanzanding van een gezogen put. Daarmee kan worden vastgesteld hoe lang het duurt eer de oorspronkelijke situatie is hersteld. Tenslotte wordt geconcludeerd dat er binnen een afstand van 10 km van de Kop van Goeree op meerdere plaatsen voldoende zand kan worden gewonnen met de punaise voor een zandsuppletie op Goeree. Voorwaarde is dan wel, dat het zand zodanig grof is, dat het op het stort blijft liggen en niet met het spuitwater wegvloeit. Een grondonderzoek moet hierover uitsluitsel geven. De kosten van een zandsuppletie met de punaise moeten eveneens worden onderzocht om te toetsen of deze uitvoeringswijze inderdaad kan concurreren met een conventionele uitvoering.kustwaterbouwkundeHydraulic EngineeringCivil Engineering and Geoscience
Willem Goeree and the production of knowledge in the early modern Netherlands
No full textNational Library of the Netherlands (Nationale Bibliotheek, KB), The Hague, March 27, 2020 CfP Deadline: Sep 22, 2019 As a prolific author, publisher and bookseller operating between Middelburg and Amsterdam, Willem Goeree represents a remarkable case study through which to investigate the processes of producing, printing and publishing knowledge in the Dutch Republic. Using Goeree and his works as a starting point, this workshop addresses topics including Goeree’s social network; his in..
De kosten van een zandsuppletie op het strand van de Kop van Goeree uitgevoerd met behulp van de zogenaamde "Punaise"
No full textIn het 1e deel van het afstudeerverslag van A.H. van Berk (lit. 1) werd de vraag gesteld of een baggersysteem voor het kustonderhoud van de Kop van Goeree met de punaise (fig. 0) in één van de wingebieden A, B of C (fig. 2) kan konkurreren met een systeem met een cutterzuiger in wingebied E. Voor het antwoord op deze vraag zijn de kosten van zowel de uitvoering met de punaise als die met de cutterzuiger bepaald. Deze kosten zijn omgerekend naar de gemiddelde jaarlijkse kosten voor het kustonderhoud en onderling vergeleken. In het tweede deel wordt een handleiding gegeven voor de berekening van de jaarlijkse kosten van het kustonderhoud van de lop van Goeree door zandsuppietie a.b.v. de Punaise.Hydraulic EngineeringCivil Engineering and Geoscience
A literature review of economic evaluations for a neglected tropical disease : human African trypanosomiasis ("sleeping sickness")
No full textHuman African trypanosomiasis (HAT) is a disease caused by infection with the parasite Trypanosoma brucei gambiense or T. b. rhodesiense. It is transmitted to humans via the tsetse fly. Approximately 70 million people worldwide were at risk of infection in 1995, and approximately 20,000 people across Africa are infected with HAT. The objective of this review was to identify existing economic evaluations in order to summarise cost-effective interventions to reduce, control, or eliminate the burden of HAT. The studies included in the review were compared and critically appraised in order to determine if there were existing standardised methods that could be used for economic evaluation of HAT interventions or if innovative methodological approaches are warranted. A search strategy was developed using keywords and was implemented in January 2014 in several databases. The search returned a total of 2,283 articles. After two levels of screening, a total of seven economic evaluations were included and underwent critical appraisal using the Scottish Intercollegiate Guidelines Network (SIGN) Methodology Checklist 6: Economic Evaluations. Results from the existing studies focused on the cost-effectiveness of interventions for the control and reduction of disease transmission. Modelling was a common method to forecast long-term results, and publications focused on interventions by category, such as case detection, diagnostics, drug treatments, and vector control. Most interventions were considered cost-effective based on the thresholds described; however, the current treatment, nifurtomix-eflornithine combination therapy (NECT), has not been evaluated for cost-effectiveness, and considerations for cost-effective strategies for elimination have yet to be completed. Overall, the current evidence highlights the main components that play a role in control; however, economic evaluations of HAT elimination strategies are needed to assist national decision makers, stakeholder and key funders. These analyses would be of use, as HAT is currently being prioritized as a neglected tropical disease (NTD) to reach elimination by 2020
Een telling van Spiranthes spiralis (L.) Chevall. op Goeree
No full textIn the dunes, named “Westduinen” on the island of Goeree (prov. S. Holland) one of the two known Dutch localities of Spiranthes spiralis (L.) Chevall. is situated. In this locality the author counted the number of flowering specimens. This number proved to be 730 (23. VIII. 1970) and 1142 (22.VIII.1971). As a rule the species flowers in the above named locality from the second half of August until the middle of September
Interprovincial Comparisons of Public and Private Sector Long-Term Care Facilities for the Elderly in Canada
No full textLong-term care services for the elderly in Canada have evolved into a vast array of types of facilities, levels and types of care and organizational arrangements, and are best characterized as operating within ten individual provincial systems. This study was undertaken in an effort to more fully understand the organization and financing of facility-based long-term care across the provinces. The wide degree of variability across systems renders interprovincial comparisons problematic and, to mitigate this, a reconciliation process was undertaken whereby facilities and beds were classified into four Categories of Care. While a few general patterns emerged, the results also serve to highlight the dissimilarities between, and within, systems. The article concludes by examining the potential value of such data to health planners and policy-makers. Coauthors are Larry W. Chambers, Amiram Gafni, Ron Goeree, and Roberta Labelle.
A Literature Review of Economic Evaluations for a Neglected Tropical Disease: Human African Trypanosomiasis (“Sleeping Sickness”)
No full textHuman African trypanosomiasis (HAT) is a disease caused by infection with the parasite Trypanosoma brucei gambiense or T. b. rhodesiense. It is transmitted to humans via the tsetse fly. Approximately 70 million people worldwide were at risk of infection in 1995, and approximately 20,000 people across Africa are infected with HAT. The objective of this review was to identify existing economic evaluations in order to summarise cost-effective interventions to reduce, control, or eliminate the burden of HAT. The studies included in the review were compared and critically appraised in order to determine if there were existing standardised methods that could be used for economic evaluation of HAT interventions or if innovative methodological approaches are warranted. A search strategy was developed using keywords and was implemented in January 2014 in several databases. The search returned a total of 2,283 articles. After two levels of screening, a total of seven economic evaluations were included and underwent critical appraisal using the Scottish Intercollegiate Guidelines Network (SIGN) Methodology Checklist 6: Economic Evaluations. Results from the existing studies focused on the cost-effectiveness of interventions for the control and reduction of disease transmission. Modelling was a common method to forecast long-term results, and publications focused on interventions by category, such as case detection, diagnostics, drug treatments, and vector control. Most interventions were considered cost-effective based on the thresholds described; however, the current treatment, nifurtomix-eflornithine combination therapy (NECT), has not been evaluated for cost-effectiveness, and considerations for cost-effective strategies for elimination have yet to be completed. Overall, the current evidence highlights the main components that play a role in control; however, economic evaluations of HAT elimination strategies are needed to assist national decision makers, stakeholders, and key funders. These analyses would be of use, as HAT is currently being prioritized as a neglected tropical disease (NTD) to reach elimination by 2020
Morphological development of the Bollen van de Ooster: A potential hazard for Goeree-Overflakkee?
No full textThe Bollen van de Ooster, in this report referred to as the Ooster, is a sand bar in the outer delta of the Grevelingen. The Ooster is separated from the coast by a relatively deep channel, called the Schaar. Closure of the Grevelingen in 1971, with the construction of the Brouwersdam, initiated vast changes in morphology. Damming of the estuary mainly affected the tide-induced flow patterns and therefore the relative influence of the waves at the outer delta. In this study the main focus is on the morphological development near the coastline of Goeree-Overflakkee. During the past years an erosion trend of locally up to 27 m/year, just south of the Flaauwe Werk, led to concerns with Rijkswaterstaat. This erosion is caused by the migration of the Ooster along the coast. Out of precaution a beach nourishment has been planned in this area due to the potential danger for the Flaauwe Werk. However, uncertainty about the future morphological development and therefore the necessity to take measures remains. The aim of this study is to provide a better understanding in the changes that have occurred, bring more certainty about the future and therefore contribute to informed decision-making. The coast of Goeree-Overflakkee has had a long history of coastline erosion. Closure of the Grevelingen estuary led to an increase of this erosion trend at the Westhoofd due to a combination of increased tide-induced flow velocities and morphological development of the Ooster. The latter was characterised by an eastward migration which forced the Schaar into the coastline. This process initiated multiple nourishments in the period 1969-1985. The attachment of one of the shoals of the Ooster resolved this problem, resulting in a large accumulation of sediments on the beach. In the years thereafter these sediments have been eroded as the Ooster migrated along the coast and transported further north. The latter resulted in beach widening along the coast of Goeree-Overflakkee. Due to the rapid elongation of the Ooster the erosion problems of the 80’s returned. The Schaar shows a continuous decrease in depth and flow surface since 2003, according to data analysis. Model results show that the channel mainly plays a role during low tide when the Ooster is emerged. Significant tide-induced flow velocities occur in the channel. In general, the decreasing channel dimensions lead to an increase of the magnitude of the flow in the channel. However, this occurs for a limited time duration during the full tidal cycle. A striking observation is the small influence of the wave angle on the wave-induced flow velocities near the channel. Waves coming from the north are refracted considerably due to the extension of the Haringvliet outer delta. The result is a large net longshore sediment transport rate at the seaward side of the Ooster. This could explain the pace of the migration in eastern direction. Moreover these sediments are a source for the channel, contributing to decreasing the channel dimensions. In general the presence of wind decrease the magnitude of the flow in the channel. Based on these findings it can be concluded that the waves are the dominant forcing mechanism in shaping the morphology and attachment of the Ooster is expected to occur in the near future. Attachment of the Ooster implies the disappearing of the eroding currents. The duration at which this attachment can be expected cannot be deduced from this study. The erosion of the coastline will continue as long as the channel is present. Based on the width of the dune row and the presence of beach groynes the potential treat of the morphological development for the primary flood defences seems minor.Civil Engineering | Hydraulic Engineerin
Advertising in the US Personal Computer Industry
No full textTraditional models of consumer choice assume consumers are aware of all products for sale.This assumption is questionable, especially when applied to markets characterized by a high degree of change, such as the personal computer (PC) industry. I present an empirical discrete-choice model of limited information on the part of consumers, where advertising influences the set of products from which consumers choose to purchase. Multi-product firms choose prices and advertising in each medium to maximize their profits. I apply the model to the US PC market, in which advertising expenditures are over $2 billion annually. The estimation technique incorporates macro and micro data from three sources. Estimated median industry markups are 19% over production costs. The high industry markups are explained in part by the fact that consumers know only some of the products for sale.Indeed estimates from traditional consumer choice models predict median markups of one fourth this magnitude. I find that product-specific demand curves are biased towards being too elastic under traditional models of consumer choice. The estimates suggest that PC firms use advertising media to target high-income households, that there are returns to scope in group advertising, and that word-of-mouth or experience plays a role in informing consumers. The top firms engage in higher than average advertising and earn higher than average markups.
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