102 research outputs found
Fat Jersey Blues
No full textI know I\u27m holding a good book in my hand when I use the other to call my friends and read poems to them. How generous John Repp is! He zooms in on the moment, but he\u27s always glancing at everything that surrounds it. His funny poems have dark hearts, just as the sad ones are clearly written by someone capable of belly-shaking laughter. They tell wonderful stories, yet they contain chewy little nuggets that are often indifferent and even hostile to story. I\u27ve said elsewhere that a poem either writes you a check or sends you a bill, and Fat Jersey Blues writes me checks faster than I can cash them. Oh, and these poems make me do something else that the good ones always do: when I hung up after reading Bob Johnson or The Maltese Falcon or Balcony to a friend, I sat down to write myself. -David Kirby, author of The Biscuit Joint
Saturated with the particularity of place, Fat Jersey Blues dramatizes a world at once actual and mythic, joyful and desolate. As American as this book is, Proust comes to mind when reading it, time slowed to the tempo of a wide river sweeping all that is mortal toward its inevitable end. As Repp writes, “. . . how can those days & these & all the others I can’t fit/into whatever I’m saying here be lived by one person?” Lucky for us, he’s made all “those days and these” fit into this marvelous book. -Lynn Emanuel, author of Noose and Hook
How rich the trove of personal, musical, and literary knowledge John Repp brings to this return to the New Jersey of his early years. The warm, adult gaze behind even the angers and disappointments in these poems is what I love in them. -Eric Torgersen, author of Heart.Wood
John Repp’s poems bear the weight of years as they strip away pretensions of all sorts. Who else could write a fully realized poem that so hilariously praises and corrects another poet, “My Wife’s Ass (or ‘You Annoy Me, Matthew Dickman!’)”? Whether sorrowing or comical, Fat Jersey Blues is never predictable. -Lee Upton, author of The Tao of Humiliation
These are poems of elegance and intimacy, informed with earned wisdom and great heart. When Blueberry (or \u27Another Summer-of-1975 Poem\u27) —one of the best narrative poems anywhere—urges you to Gather with me in the kitchen where the floorboards/ sag & squeak. . . accept the invitation. You will return to Fat Jersey Blues often, grateful to be reminded how rare and essential poets of John Repp\u27s caliber are. -Linda Lee Harper, author of Kiss, Kisshttps://ideaexchange.uakron.edu/uapress_publications/1184/thumbnail.jp
Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity
No full textAb-dependent polymorphonuclear granulocyte (PMN)-mediated cytotoxicity may play an important role in the control of malignant diseases. However, little is known as to which particular pathways are used for the killing of malignant cells by PMN. The production of reactive oxygen intermediates (ROI) has been observed to occur during Ab-dependent, cell-mediated cytotoxicity (ADCC). However, PMN from a patient with chronic granulomatous disease demonstrated strong ADCC against malignant lymphoma cells. Furthermore, the inhibition of ROI production in PMN from healthy donors had no significant effect on ADCC. Therefore, ROI production by the NADPH oxidase of PMN does not appear to be mandatory for PMN-mediated ADCC. Recent data suggest a role for perforins in PMN-mediated cytotoxicity. However, in our assays concanamycin A, an inhibitor of perforin-mediated ADCC by mononuclear cells, had no inhibitory effect on PMN-mediated ADCC. Using electron microscopy we observed that PMN and their target cells intimately interact with the formation of interdigitating membrane protrusions. During PMN and target cell contact there was a mutual exchange of fluorescent membrane lipid dyes that was strongly increased in the presence of tumor-targeting Abs. This observation may be closely related to the recently described process of trogocytosis by lymphocytes. The presence of transient PMN-tumor cell aggregates and the accumulation of PMN with tumor cell-derived membrane lipids and vice versa were associated with effective ADCC as measured by chromium-release or apoptosis induction. <br/
Martin Repp: Hōnens religiöses Denken. Eine Untersuchung zu Strukturen religiöser Erneuerung
No full textThe title of this major new work by Martin Repp could be translated into English as “Hōnen’s Religious Thought; An Investigation into Structures of Religious Renewal”, and this title already says a great deal, quite precisely, about the approach which the author takes. First, the book is above all about the religious thought of the Japanese Buddhist Hōnen (1133-1212), and not mainly about his life or activities
Mechanisms of G-CSF- or GM-CSF-stimulated tumor cell killing by Fc receptor-directed bispecific antibodies
No full textStudies with gene-modified mice have recently reinforced the importance of Fc receptor-mediated effector mechanisms for the therapeutic efficacy of rituxan and herceptin — two clinically approved antibodies for the treatment of tumor patients. We investigated Fc receptor-dependent tumor cell killing by mononuclear and granulocytic effector cells — comparing human IgG1 antibodies against CD20 or HER-2/neu with their respective Fc?RI (CD64)-, Fc?RIII (CD16)-, or Fc?RI (CD89)-directed bispecific derivatives. With blood from healthy donors as effector source, human IgG1 and Fc?RIII (CD16)-directed bispecific antibodies proved most effective in recruiting mononuclear effector cells, whereas tumor cell killing by granulocytes was most potently triggered by Fc?RI-directed bispecific constructs. Granulocyte-mediated tumor cell lysis was significantly enhanced when blood from G-CSF- or GM-CSF-treated patients was investigated. Interestingly, however, both myeloid growth factors improved effector cell recruitment by different mechanisms, which were furthermore dependent on the tumor target antigen, and on the selected cytotoxic Fc receptor
Martin Repp: Aum Shinrikyo. Ein Kapitel krimineller Religionsgeschichte
No full textThis important work is a well considered and reliable account of the Japanese religion Aum Shinrikyo, leading members of which, including the founder, have recently been accused of very serious crimes. These crimes include a series of individual murders and two mass terrorist attacks with the use of sarin gas, in Matsumoto and in Toyko, which led to several deaths and numerous severe injuries. The author, Martin Repp, is the associate director of the NCC (National Christian Council) Center for the Study of Japanese Religions, and, being based in Kyoto, Japan, has been able to follow the relevant events very closely in the media. In this review attention will be drawn to just a few salient points, but in whatever way the discussion continues on these, the book itself is an important resource, and one of the earliest documentations of Aum written with academic care
Selektive Aktivierung Dendritischer Zellen durch rekombinante CD40-gerichtete Tribodies im Hinblick auf die Anti-Tumor-Vakzinierung beim Multiplen Myelom
No full textTrotz großer Fortschritte in der Behandlung des Multiplen Myeloms in den letzten 20
Jahren kann nur in Ausnahmefällen eine Heilung erreicht werden. Immer häufiger ist
es möglich, die Erkrankung bis auf eine minimale Resterkrankung (MRD) zurück zu
drängen. Neue Therapiestrategien zur Kontrolle der MRD sind daher von großem
Interesse. Dabei rücken zunehmend immuntherapeutische Strategien zur Anti-
Tumor-Vakzinierung in das Interesse der Forschung. Neben der Vakzinierung der
Patienten mit ex vivo generierten, mit Antigen-beladenen und nachfolgend gereiften
Dendritischen Zellen (DZ) oder aber dem adoptiven Transfer Tumorantigenspezifischer
T-Zellen kommt insbesondere die in vivo-Applikation von Antigen und
Reifungsstimulus in Betracht.
In dieser Arbeit wurden bispezifische Konstrukte entwickelt, um die Präsentation von
Tumorantigen in DZ über eine gezielte Aufnahme über Endozytoserezeptoren zu
verbessern und simultan eine Reifung der DZ über eine CD40-Aktivierungsdomäne
zu induzieren
Improved Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) of Affinity Maturated and Fc-Engineered Antibodies Directed Against the AML Stem Cell Antigen CD96
No full textRegardless of progress in the therapy of AML, there is no long-term cure for about 70% of AML patients. Leukemic stem cells seem to be an important key for the perpetuation of AML.Most currently used chemotherapeutic agents are not able to eliminate AML-LSCs. The combination of conventional therapies with AML-LSCs-directed therapies may eventually lead to a cure for AML patients.Recently expression of CD96 was reported on AML-LSCs, while only very low expression levels were found on normal HSCs.Therefore CD96 may be an excellent target antigen for therapeutic antibodies directed against AML stem cells and blasts
Eine vergleichende Untersuchung unterschiedlicher Strategien der Darmdekontamination bei der allogenen Stammzelltransplantation
No full textDie Auswirkungen der Zusammensetzung des intestinalen Mikrobioms auf die allo HSCT sind komplex und bis heute noch nicht vollständig verstanden. Es bleibt umstritten, inwieweit eine hohe Diversität des Mikrobioms zu einem verbesserten Outcome, zu geringeren Raten an GvHD sowie an Infektionen führt. Vor diesem Hintergrund betrachtet diese Dissertationsschrift vergleichend zwischen zwei Gruppen mit unterschiedlichen Darmdekontaminationsstrategien ein Patientenkollektiv nach allo HSCT. Hierbei konnte gezeigt werden, dass Patienten, die unter Rifaximin eine Darmflora mit vermeintlich höherer Diversität hatten, unter signifikant weniger Clostridioides-difficile-Infektionen litten als Patienten mit einer geringeren Vielfalt der Kommensalen. Des Weiteren entwickelten Patienten unter Rifaximin nicht mehr infektiöse Komplikationen in Neutropenie und nicht mehr GvHD im Vergleich zu Patienten unter Ciprofloxacin-/Colistin-Behandlung. Aus der Evaluation der Daten innerhalb dieser Studie lässt sich schließen, dass die Umstellung der intestinalen Prophylaxe bei allo HSCT von Colistin und Ciprofloxacin zu Rifaximin im Rahmen dieser Studienpatienten keine größeren Risiken und Komplikationen birgt und dass diese Umstellung somit angesichts der verminderten Rate an CDI erfolgreich war und auch in Zukunft beibehalten werden kann. Das ist ein bedeutendes Ergebnis der Arbeit, da es bedeutet, dass es das Fortführen der innovativen Darmdekontamination weiterhin erlaubt
Generierung von dendritischen Zellen bei Patienten mit einem Multiplen Myelom
No full textZusammenfassend gelang es in der vorliegenden Arbeit reife dendritische Zellen aus Blutmonozyten von Patienten mit Multiplem Myelom zu generieren. Die Fähigkeit zur Antigenpräsentation und Aktivierung von T-Lymphozyten durch die dendritischen Zellen konnte nachgewiesen werden
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