8 research outputs found
One step synthesis of kestarite Cu2ZnSnS4 thin film by simple and economic chemical bath deposition method
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Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases
No full textPeptide-based drugs are gaining significant momentum in the modern drug discovery, which is witnessed by the approval of new drugs by the FDA in recent years. On the other hand, small molecules-based drugs are an integral part of drug development since the past several decades. Peptide-containing drugs are placed between small molecules and the biologics. Both the peptides as well as the small molecules (mainly heterocycles) pose several drawbacks as therapeutics despite their success in curing many diseases. This gap may be bridged by utilising the so called ‘conjugation chemistry’, in which both the partners are linked to one another through a stable chemical bond, and the resulting conjugates are found to possess attracting benefits, thus eliminating the stigma associated with the individual partners. Over the past decades, the field of molecular hybridisation has emerged to afford us new and efficient molecular architectures that have shown high promise in medicinal chemistry. Taking advantage of this and also considering our experience in this field, we present herein a review concerning the molecules obtained by the conjugation of peptides (amino acids) to small molecules (heterocycles as well as bioactive compounds). More than 125 examples of the conjugates citing nearly 100 references published during the period 2000 to 2022 having therapeutic applications in curing infectious diseases have been covered
A promising approach for improved citric acid production by Aspergillus niger with the assistance of cinnamaldehyde derivatives
No full textConsidering the importance of food preservation, this study presents the synthesis of cinnamaldehyde derivatives
i.e., chalcones and pyrazoles with an atom economy of >92 % using an energy-efficient and eco-friendly mi-
crowave-assisted synthesis with high purity and yield. All the compounds were evaluated for their ability to
enhance the growth of Aspergillus niger for citric acid production via submerged fermentation, which showed that
the pyrazoles significantly outperformed both untreated samples and chalcones in citric acid production, with
enhancements of up to 25-times and 4-times, respectively. Compounds at lower concentrations yielded citric acid
levels of 100–113 g/L. The purity and authenticity of citric acid recovered were confirmed through spectral
studies. Molecular docking against aconitase enzyme from nine different sources revealed various types of in-
teractions with binding affinities ranging from 7.2 to 10. The target compounds can be regarded as valuable
“lead compounds” for citric acid production, effectively addressing both demand and supply
Fast and affordable detection of PKU disease using iron (III) chloride-based solutions and porous PCL biosensors at higher prediction rates
No full textThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Phenylketonuria (PKU), a prevalent genetic metabolic disorder, poses substantial diagnostic and treatment challenges globally. Current treatments primarily revolve around strict dietary management, necessitating lifelong commitment and frequent monitoring of phenylalanine (Phe) levels in the body. This study introduces an innovative diagnostic approach utilizing iron (III) chloride solution and highly porous polycaprolactone (PCL)-based solid biosensors for cost-effective, user-friendly detection of L-phenylalanine (L-Phe) in urine, which reflects systemic Phe levels. These biosensors operate through colorimetric changes, quantified using red, green, and blue (RGB), hue, saturation, and lightness (HSL), and cyan, magenta, yellow and black (CMYK) color models, to determine the concentrations of Phe in urine when incorporated with iron (III) chloride. Laboratory tests confirmed that the proposed iron chloride-based liquid and solid sensors are fast, sensitive, specific, and reliable depending on the Phe concentrations. This method promises to simplify home-based monitoring, providing a real-time, low-cost alternative to traditional blood tests, thereby potentially improving patient compliance and outcomes in managing PKU disease. The findings emphasize the potential use of the liquid and PCL-based biosensors in bridging gaps in access to essential diagnostic services for PKU patients. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024
