380 research outputs found
Métricas de autor Luis Alberto Quiroga Baquero
No full textInforme de las métricas de autor del Dr. Luis Alberto Quiroga Baquero de las publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo para el fortalecimiento de las capacidades y potencialidades de los autores de la Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicaciones.Report of the author metrics Luis Alberto Quiroga Baquero of the publications indexed in Google Scholar whose objective is to provide an input for the strengthening of the capacities and potentialities of the authors of the Santo Tomás University in the positioning and visibility of their publications.http://unidadinvestigacion.usta.edu.c
Recommended from our members
Fantastic B-Cells and Where to Find Them
No full textSince the SARS-CoV-2 pandemic began in 2020, viral sequencing has documented the emergence of hundreds of individual mutations in the viral spike protein across numerous variants. With the drastic viral evolution over the past four years resulting in variants with greater than 60 mutations relative to the Wuhan strain the vaccine has been updated three times. Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse SARS-CoV-2 variants. However, the development of antibodies and humoral immune responses capable of neutralizing across the coronavirus family is poorly understood. The ongoing spread of COVID-19 underscores the importance of identifying and characterizing neutralizing monoclonal antibodies capable of neutralizing all variants. The fusion peptide (FP) region of the viral spike protein is a crucial target for neutralization given its broad cross reactivity and conservation among all the coronaviruses.
Here, we determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 evolution. Updated vaccines increase neutralization breadth, but viral evolution continues to outpace them. Using newly developed depletion protocols we show that broadly neutralizing responses are often a result of receptor binding domain (RBD) specific antibodies, but some donors produce FP-specific responses that contribute to neutralization breadth. In a comprehensive ELISA study, we find that FP-specific antibodies arise only in response to natural infection and not vaccination. Next, we developed a novel protocol to isolate antigen-specific memory B-cells and monoclonal antibodies (mAbs) in less than 1 week. Using this highly efficient and effective protocol, we isolated 11 FP-specific antibodies with varying neutralization breadths. Finally, we designed a set of pseudoviral spike proteins to assess epitope and escape mutations for FP-specific antibodies. We found that mutations at S816 and F823 escape all FP-specific antibodies. Collectively, this work helps elucidate the co-evolution of the humoral immune response and the SARS-CoV-2 virus, suggesting that novel vaccine strategies are needed to end the spread of the virus and prevent further viral evolution. In this thesis we also present a roadmap for the selection of ideal donors for mAb isolation and offer a highly efficacious protocol for generation of mAbs from donor PBMCs.Medical Science
Gender and Translation: Spanish Translation of Virginia Woolf’s Orlando, by Jorge Luis Borges
No full textJorge Luis Borges translated into Spanish Orlando: A Biography, written by Virginia Woolf, nine years after its publication, in 1928. In the novel, Virginia Woolf sought to chart a path that would lead to a perfect harmony between the two sexes in the mind. However, the translation of the Argentine author has a number of changes that allows us to examine the personal character that he gave to his translation as a reflection of his conscious or unconscious covert patriarchal ideology
Ficha bibliométrica autor USTA - Luis Germán Ortega-Ruiz
No full textInforme de las métricas de autor del Dr. Luis Germán Ortega-Ruiz de las
publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo
para el fortalecimiento de las capacidades y potencialidades de los autores de la
Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicaciones.Report of the author metrics Luis Germán Ortega-Ruiz of the publications indexed
in Google Scholar whose objective is to provide an input for the strengthening of the
capacities and potentialities of the authors of the Santo Tomás University in the
positioning and visibility of their publications.http://unidadinvestigacion.usta.edu.c
Pessimist Metaphysics and Ontology in the Work of Jorge Luis Borges
No full text284 pagesThis dissertation analyzes the metaphysics elicited from the ontology of the work of art in Jorge Luis Borges. It does so by first questioning what worldview is evinced from the text at the level of the sentence, analyzing recurrent words such as atroz and maravilla as indicating a preoccupation with metaphysics. It is then shown that this preoccupation with metaphysics is indebted to the philosophy of Schopenhauer, and how he conceives of the Will as metaphysical, and therefore also as the cause and justification of pessimism, as the Will produces suffering in a striving toward completion which remains ever inchoate. Of particular import is an analysis of the story “Undr” and its correlation to philosophical Verwunderung as expressed in Schopenhauer’s essay “On Man’s Need of Metaphysics” in the second volume of the World as Will and Representation. After establishing this metaphysical relation with pessimism, it is shown how this worldview is manifested in various texts of Borges, in particular “Utopía de un hombre que está cansado,” whose resolution corresponds to Schopenhauer’s analysis of how subjects should interact with the Will if they are able to discover it. Lastly, it is argued that this preoccupation with metaphysics as something atrocious is built into the structure or formal ontology of interpretation, which posits that both precursors and successors to a given author are hermeneutically related to this author as inaccessible event and arche (____). Here a discussion of “Kafka y sus precursors” is indispensable, as well as a reading of some of Borges’s successors, such as Pablo Katchadjian and Agustín Fernández Mallo. What makes Borges a particularly useful case study of this is the fact that his writing takes this dynamic into account and manifests it in the worldview presented in the very individual pieces of his writing
Radar Sensing in Healthcare: Challenges and Achievements in Human Activity Classification & Vital Signs Monitoring
No full textDriven by its contactless sensing capabilities and the lack of optical images being recorded, radar technology has been recently investigated in the context of human healthcare. This includes a broad range of applications, such as human activity classification, fall detection, gait and mobility analysis, and monitoring of vital signs such as respiration and heartbeat. In this paper, a review of notable achievements in these areas and open research challenges is provided, showing the potential of radar sensing for human healthcare and assisted living.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Microwave Sensing, Signals & System
Arte y antropología. 71 Nueva Época (2003) julio-septiembre. Antropología. Boletín Oficial del Instituto Nacional de Antropología e Historia
No full text- Fotomontaje en México: razones sociopolíticas por José Antonio Rodríguez. - Algo más que la inocencia (notas en torno a algunas coincidencias de la antropología y la literatura) por David Martín del Campo. - Eric Jervaise: la fotografía como intuición por Mauricio Carrera. – Aerocromacias por Felipe Ehrenberg. - Los investigadores vistos en la fotografía por Deborah Dorotinsky. - Anita Brenner en la fotografía mexicana y su expedición etnofotográfica a Guerrero por Samuel Villela F. - Los caminos de Alejandro Casarín (1840-1907) por Esther Acevedo. - Las huellas del paisaje en Alexander von Humboldt por Rosa Casanova. - Reflexiones sobre la llamada “cultura popular”: un vagón escasamente tripulado en el tren de la historiografía de la Revolución Mexicana por Ricardo Pérez Montfort. - Ópticas, emblemas y alegorías en dos frontispicios europeos del siglo XVII por Ma. Celia Fontana Calvo. - Hernán Cortés inventor de México: una metáfora infortunada por Luis Barjau. - Soldados de Salamina: historia y literatura por Benigno Casas de la Torre. - Cine e Historia (un breve comentario) por Juan Antonio Barrio Barrio
Eugene Onegin and Russian Identity
No full textThis paper examines the Russian novel Eugene Onegin and the extent to which different themes of the book are reflective of a Russian identity crisis. Analyzing the book from a historical perspective, this essay shows how the author Alexander Pushkin cleverly drafted a novel demonstrative of this identity crisis and the influence of foreign works in Russia. 
Hydraulic models in Turkmenistan
No full textPresented at the 2002 USCID/EWRI conference, Energy, climate, environment and water - issues and opportunities for irrigation and drainage on July 9-12 in San Luis Obispo, California.In 1998 irrigated area of Turkmenistan was 1750 thousand ha and total water intake was 22.8 km3 which was enough to meet total agricultural water requirements. Pursuant to the programs of the President of Turkmenistan, the irrigated area must be brought to 2250 thousand ha by 2010, but the volume of water taken from the Amudarya river must be kept as 22 km3. Thus in the future irrigation water requirements including the necessity of irrigated area extension can be met only under specific conditions. The given situation demands much from the justification and quality of the projects. In this connection, at present, in the course of designing and renovation of major water projects (reservoirs, main canals and drainage systems) of Turkmenistan, hydrological models and engineering calculation schemes are being used. Sources of initial hydrological data and methods of their processing (depending upon the sphere of their utilization, results of hydrological studies and the problems which solution they will be used for) are under consideration in the Report
Theory and Practice of Paradiplomacy: Subnational Governments in International Politics [RESEÑA]
No full text“This is an Accepted Manuscript of an article published by Taylor & Francis in Regional & Federal Studies on 2016, available online: https://www.tandfonline.com/doi/abs/10.1080/13597566.2016.1157072”.This book is based upon the research and findings carried out by Alexander Kuznetsov concerning his PhD dissertation on paradiplomacy and the role of subnational governments in international affairs. As pointed out by the author, paradiplomacy is generally referred to in the academic literature as the involvement
of the constituent units (regions) of (multi)national states in international affairs. Examples of these meso units are the states in the United States, the provinces in Canada, the Länder in Germany, the oblasts and the republics in Russia, and the autonomous communities in Spain. A focus on the phenomenon of paradiplomacy
in its theoretical and practical aspect is meant to shed light on an area of study of increasing interest for academics and practitioners, as it plays a significant role in shaping the foreign and domestic policies of central governments.Peer reviewe
- …
