59,461 research outputs found
Histological and paleogenetic analyses of a pre-Columbian mummy: Gut microbiome and antibiotic-resistence genes
No full textE-cigarettes induce toxicological effects that can raise the cancer risk. A frame from drug-metabolism and antioxidant homeostasis
No full textE-CIGARETTES INDUCE TOXICOLOGICAL EFFECTS THAT CAN RAISE THE CANCER RISK. A FRAME
FROM DRUG-METABOLISM AND ANTIOXIDANT HOMEOSTASIS.
1)Canistro D. 2)Vivarelli F. 3)Cirillo S. 4)Cardenia V. 5)Rodriguez-estrada MT.
Dept of Pharmacy and Biotechnology, Unibo
Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution without tobacco combustion. Perceived as a safer alternative to conventional cigarettes, e-cigs are aggressively marketed as lifestyle-choice consumables, thanks to few restrictions and a lack of regulatory guidelines. Despite the burgeoning worldwide consumption of e-cigs, their safety remains largely unproven and it is unknown whether these devices cause in vivo toxicological effects that could contribute to cancer occurrence.
In the present study, we investigated the co-mutagenic and cancer-initiating effects of e-cig vapour in a rat model. To explore whether e-cigs induce toxicological effects, such as those involving cytochrome P450 (CYP) changes, we analyzed the modulation of carcinogen metabolizingenzymes in the lung of rats exposed to e-cig vapour. We observed a significant increase in CYP1A1/2 (activating, for example, polychlorinated biphenyls, aromatic amines, dioxins and PAHs), CYP2B1/2 (activating olefins and halogenated hydrocarbons), 2C11 (activating nitrosamines and mycotoxins) and CYP3A (activating hexamethyl phosphoramide and nitrosamines) documented by the sharp rise in the corresponding probes.
Conversely, we observed that the antioxidant enzymes catalase, DT-diaphorase and glutathione peroxidase and the conjugating phase II glutathione S-transferases, mainly involved in xenobiotic detoxification, were noticeable decreased, whereas UDP-glucuronyl-transferase was substantially unchanged.
Extrapolated to humans, the corresponding boosted CYP-linked monooxygenases together with reduced activity of antioxidant and detoxifying machinery would predispose a subject to an enhanced cancer risk from the widely bioactivated e-cig vapour procarcinogens associated with an increased risk of lung cancer
LaTeX as an inclusive accessibility instrument for highschool mathematical education
No full textThis paper describes the design, implementation and outcomes of a teaching activity in high school setting, aimed at supporting a student with visual impairments in learning Mathematics and promoting inclusive learning involving all other students. The teaching activity was defined following an adoption-centered approach. During the initial needs-finding stage, we explored the available instruments for inclusive access and authoring of mathematical formulae, and we identified the LaTeX typesetting language as the instrument of choice. The use of LaTeX was motivated by the fact that it provides a textual representation of mathematical content, thus making it accessible through standard assistive technologies, such as Braille displays and screen readers. LaTeX is also widely used in higher education to author scientific documents, and therefore constitutes a useful skill for future education and employment of all students. We then defined the main steps needed for addressing the topic during a traditional high school mathematical curriculum, and scheduled them in relation to other teaching activities. The students had no difficulties in following the teaching activity, including learning and using LaTeX, and most were eager to apply the acquired skills for authoring lab reports and homework. However, the acceptance of the assistive tool by the student with visual impairments was low. Additionally, most of the other teachers displayed high resistance to change and therefore were not interested in supporting the activity and integrating it with their classes. We highlight the key findings and limitations of the project, and discuss possible improvements over the current approach
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
Design and Analysis of a Distributed TRIC concept Seamless Smart Morphing Wing
No full textThis thesis embarked upon establishing and validating a design process to build and control a distributed TRIC concept seamless smart morphing wing to achieve simultaneous load alleviation, flutter suppression and drag minimization capabilities. A novel aeroelastic simulation tool was built to carry out composite wing skin optimization, with prototype testing carried out to design a flexible connection between modules. The work output was a fully built morphing wing which was successfully tested in the TU Delft Open Jet Facility. Control of the wing was partially made feasible through the development of a surrogate model of the system which was also validated with DIC testing.https://www.youtube.com/watch?v=SdagIiYRWyA&t=1s Smart-X Alpha DemonstratorAerospace Engineerin
Validation of the V-index through Finite Element 2D Simulations.
No full textA physiological spatial heterogeneity of ventricular repolarization (SHVR) is responsible for the T-wave on the ECG. However, an increased SHVR might favor the development of ventricular arrhythmias. The V-index is a metric introduced with the aim of assessing SHVR from ECG.
In this work, the V-index was validated by means of 2D computer simulations, using a modified version of the ten Tusscher-Panfilov (TP06) model that accounts for repolarization variability. Synthetic ECG were simulated at 12 different positions at the external surface with two different strategies. Also, a theoretical extension of the V-index definition was derived, to address situations where fluctuations in repolarization times are correlated across nodes.
At tissue level, theoretical values of V-index were in agreement with SHVR with a constant pacing (maximum error: 3.4 ms). However, with a variable RR, a selection of stationary beats was necessary to overcome the stronger temporal correlation across nodes (maximum error: 3.2 ms). On the other hand, values of V-index numerically estimated from the ECG were always in agreement with their theoretical values (average error in the estimates: 15 perpendicular to 9%). The results confirmed that the V-index indeed provides an approximate and reliable measure of SHVR
Título: De immunitate ecclesiarum
No full textColofón en v. de V\b7\sColofónSign.: *\p8\s, A-V\p8\sPort. con grab. xil. de S. Pedro y S. PabloSign.: *\p8\s, A-T\p8\s, V\p7\
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
[Leyes, etc. sobre ultramar]
No full textCopia digital. España : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, d2024Encuadernación holandesa.El imp. de los t. III-V es José Fernández Cancela y de los t. VI-XVI Manuel Minuesa.T. I. (X, 702, V p.) -- T. II. (743, V p.) -- T. III. (640 p.) -- T. IV. (708, V p.) -- T. V. (494, II p.) -- T. VI. (744, VI p., 3 h. pleg.) -- T. VII. (488 p.) -- T. VIII. (831, III p.) -- T. IX. (830, IV p.) -- T. X. (785, VI, p.) -- T. XI. (479, IV p.) -- T. XII. (445, V p.) -- T. XIII. (559, VI p.) -- T. XIV. (379 p.) -- T. XV. (683, XI p.) -- T. XVI. (330, XXXVI p.)Registro de la Propiedad Intelectual: Ley de 1847: 9598, 9621, 9747 ; n. de solicitud de ingreso: "9266"; firma del depositante: "Joaquín Rodríguez San Pedro"Sello: "Biblioteca del Ministerio de Fomento"Sello: "Universidad Central, Artes y oficios, Biblioteca
- …
