7,826 research outputs found
Analysis of ecosystem services provision in the Colombian Amazon using participatory research and mapping techniques
No full textOver the last two decades indigenous peoples in the lower Caquetá River basin in Colombia have experienced detrimental changes in the provision of important ecosystem services in ways that have significant implications for the maintenance of their traditional livelihoods. To assess these changes we conducted eight participatory mapping activities and convened 22 focus group discussions. We focused the analysis on two types of change: (1) changes in the location of ecosystem services provisioning areas and (2) changes in the stock of ecosystem services. The focal ecosystem services include services such as provision of food, raw materials and medicinal resources. Results from the study show that in the past two decades the demand for food and raw materials has intensified and, as a result, locations of provisioning areas and the stocks of ecosystem services have changed. We found anecdotal evidence that these changes correlate well with socio-economic factors such as greater need for income generation, change in livelihood practices and consumption patterns. We discuss the use of participatory mapping techniques in the context of marginalized and data-poor regions. We also show how this kind of information can strengthen existing ecosystem-based management strategies used by indigenous peoples in the Colombian Amazon
Armas contra la fortuna, fabula temida de los hombres : maximas politicas y morales sobre Boethio De Consolatione Philosophica... : repartido en metro y prosa, sirviendo de norte Boethio a quien traducido se aplican varias digresiones
No full textColofónSign.: [calderón]-2[calderón]\p4\s, 3[calderón]\p2\s, A-Z\p4\s, 2A-2Z\p4\s, 3A-3Z\p4\s, 4A-4E\p4\s, 4F\p2\sPort. con orla ti
The rector of the hospital and his wife: two artificial mummies of the late 15th century from Siena (central Italy)
No full textTwo artificial mummies found in the hospital church of S. Maria della Scala in Siena (Tuscany, central Italy) and dated bock to the end of the 15th century, were examined. The mummies, in good state of preservation and still wearing their renaissance clothes, were identified as the rector of the hospital, named Salimbene Capacci, and his wife, Margherita Sozzini. Imaging studies, X-rays and CAT were performed. Autopsy made it possible to ascertain that the bodies had been eviscerated by a longitudinal cut from the neck to the pubis and that the thoracic and abdominal cavities had been filled with vegetable material. The pelvis was not eviscerated and the pelvic organs were conserved. The skull showed no traces of craniotomy or excerebration
Autopsy and embalming of the Medici Grand Dukes of Florence (16th-18th centuries)
No full textThe exploration of the Medici tombs in Florence allowed us to study 20 individuals, currently skeletonized but originally almost all artificial mummies. Accurate examination of the skeletons revealed evident signs of autopsy and embalming, such as thin incisions of the external skull, horizontal and oblique craniotomies, longitudinal and transversal cuts of the sternum, and sectioning of the sternal extremities of the ribs. Study of these skeletons offers important information on the autopsy and embalming techniques of the 16th century court surgeons. Finally, the finding of an entire internal cast of the mummy of a 5-year-old child witnesses on the different types of plants and substances used to embalm the bodies in Florence during the Renaissance
Effects of COVID-19 lockdown on tumour burden of melanoma and cutaneous squamous cell carcinoma
No full textTejera-Vaquerizo, A (Tejera-Vaquerizo, Antonio); Paradela, S (Paradela, Sabela); Toll, A (Toll, Agusti); Santos-Juanes, J (Santos-Juanes, Jorge); Jaka, A (Jaka, Ane); Lopez, A (Lopez, Alba); Canueto, J (Canueto, Javier); Bernal, A (Bernal, Alvaro); Villegas-Romero, I (Villegas-Romero, Isabel); Fernandez-Pulido, C (Fernandez-Pulido, Carla); Perandones, H (Perandones, Hector); Moreno-Ramirez, D (Moreno-Ramirez, David); Dominguez-Mahamud, C (Dominguez-Mahamud, Carolina); Salido-Vallejo, R (Salido-Vallejo, Rafael); Sanmartin, O (Sanmartin, Onofre); Almazan-Fernandez, FM (Almazan-Fernandez, Francisco M.); Rodriguez-Jimenez, P (Rodriguez-Jimenez, Pedro); Banuls, J (Banuls, Jose); Podlipnik, S (Podlipnik, Sebastian); Sandoval-Clavijo, A (Sandoval-Clavijo, Alejandra); Boada, A (Boada, Aram); Garcia-Bracamonte, B (Garcia-Bracamonte, Beatriz); Palencia, S (Palencia, Sara); Revilla-Nevreda, D (Revilla-Nevreda, David); Reola-Ramirez, E (Reola-Ramirez, Enara); Gomez-Mateo, MD (del Carmen Gomez-Mateo, Maria); Linares-Barrios, M (Linares-Barrios, Mario); Jimenez-Gallo, D (Jimenez-Gallo, David); Gonzalez-Cruz, C (Gonzalez-Cruz, Carlos); Samaniego, E (Samaniego, Elia); Navedo-De Las Heras, M (Navedo-De Las Heras, Maria); Taberner, R (Taberner, Rosa); Rodenas-Herranz, T (Rodenas-Herranz, Teresa); Garcia-Donoso, C (Garcia-Donoso, Carmen); Puig, S (Puig, Susana); Nagore, E (Nagore, Eduardo
The rector of the hospital and his wife: two artificial mummies of the late 15th century from Siena (central Italy)
No full textTwo artificial mummies found in the hospital church of S. Maria della Scala in Siena (Tuscany, central Italy) and dated back to the end of the 15th century, were examined. The mummies, in good state of preservation and still wearing their Renaissance clothes, were identified as the rector of the hospital, named Salimbene Capacci, and his wife, Margherita Sozzini. Imaging studies, X-rays and CAT were performed. Autopsy made it possible to ascertain that the bodies had been eviscerated by a longitudinal cut from the neck to the pubis and that the thoracic and abdominal cavities had been filled with vegetable material. The pelvis was not eviscerated and the pelvic organs were conserved. The skull showed no traces of craniotomy or excerebration
Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease
No full textCollection of auxiliary data to reproduce the results from "Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease".
Source code is available at: https://github.com/saezlab/MOFAcell
Exceptions: Spatial data is excluded
This folder contains processed data of the following publications, when using the data cite accordingly:
1) Kuppe C, Ramirez Flores RO, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, Wünnemann F, Nagai JS, et al (2022) Spatial multi-omic map of human myocardial infarction. Nature 608: 766–777
2) Ramirez Flores RO, Lanzer JD, Holland CH, Leuschner F, Most P, Schultz J-H, Levinson RT & Saez-Rodriguez J (2021) Consensus Transcriptional Landscape of Human End-Stage Heart Failure. J Am Heart Assoc 10: e019667
3) Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, et al (2022) Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science 377: eabo1984
4) Chaffin M, Papangeli I, Simonson B, Akkad A-D, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, et al (2022) Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature 608: 174–18
Impact of adipokines and myokines on fat browning
No full textSince the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction and obesity, but also in fat browning, a process that induces a phenotypic switch from energy-storing white adipocytes to thermogenic brown fat–like cells. The fat browning process and, consequently, thermogenesis can also be stimulated by physical exercise. Contracting skeletal muscle is a metabolically active tissue that participates in several endocrine functions through the production of bioactive factors, collectively termed myokines, proposed as the mediators of physical activity–induced health benefits. Myokines affect muscle mass, have profound effects on glucose and lipid metabolism, and promote browning and thermogenesis of white AT in an endocrine and/or paracrine manner. The present review focuses on the role of different myokines and adipokines in the regulation of fat browning, as well as in the potential cross-talk between AT and skeletal muscle, in order to control body weight, energy expenditure and thermogenesis
Technology\u27s Unexpected Consequences
No full textGetting people excited about science is the passion of Ainissa Ramirez, author and science “evangelist,” who spreads her “gospel” through books, TED Talks, online videos and the podcast “Science Underground.” She was named one of the world’s 100 Top Young Innovators by Technology Review for her contributions to transforming technology and has been the recipient of the American Institute of Physics’ Andrew Gemant Award.
Ramirez spent eight years teaching mechanical engineering & materials science as an associate professor at Yale University and also has been a visiting professor at MIT. She is the author or coauthor of three books, including 2013’s “Newton’s Football: The Science Behind America’s Game,” an entertaining and enlightening look at the big ideas underlying the science of football.
She has served as a science advisor to the American Film Institute, WGBH/NOVA and the American Association for the Advancement of Science, among others.
Her appearance is supported by the Spoerl Lectureship in Science in Society
Prospects for tritordeum (×Tritordeum martinii A. Pujadas, Nothosp. Nov.) cereal breeding: Key points for future challenges
No full textTritordeum is the new cereal derived from crosses between the wild barley Hordeum chilense Roem. et Schultz. and either durum or bread wheat, resulting in hexaploid and octoploid tritordeums, respectively. The success of tritordeum as a crop depends on the effectiveness of its breeding programme. In this work, new advanced tritordeum lines are screened for grain carotenoid content and disease susceptibility to analyse the impact of the current breeding strategies and to identify their strengths and putative limitations for future challenges. We conclude that selection for grain carotenoid content, the main strength for the tritordeum commercialization, should be reinforced not only by using the diversity of H. chilense but also incorporating beneficial alleles from durum wheat. Furthermore, genes for stem rust resistance from the A and B wheat genomes must be incorporated into tritordeum breeding programme. Finally, when selecting for threshability, tritordeums without chromosome substitutions should be preferentially selected using a marker-assisted selection approach
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