1,721,107 research outputs found
Microstructural model for cyclic hardening in F-actin networks crosslinked by α-actinin
Full text linkThe rheology of F-actin networks has attracted a great attention during the last years. In order to gain a complete understanding of the rheological properties of these novel materials, it is necessary the study in a large deformations regime to alter their internal structure. In this sense, Schmoller et al. (2010) showed that the reconstituted networks of F-actin crosslinked with α-actinin unexpectedly harden when they are subjected to a cyclical shear. This observation contradicts the expected Mullins effect observed in most soft materials, such as rubber and living tissues, where a pronounced softening is observed when they are cyclically deformed. We think that the key to understand this stunning effect is the gelation process. To define it, the most relevant constituents are the chemical crosslinks - α-actinin -, the physical crosslinks - introduced by the entanglement of the semiflexible network - and the interaction between them. As a consequence of this interaction, a pre-stressed network emerges and introduces a feedback effect, where the pre-stress also regulates the adhesion energy of the α-actinin, setting the structure in a metastable reference configuration. Therefore, the external loads and the evolvement of the trapped stress drive the microstructural changes during the cyclic loading protocol. In this work, we propose a micromechanical model into the framework of nonlinear continuum mechanics. The mechanics of the F-actin filaments is modelled using the wormlike chain model for semiflexible filaments and the gelation process is modelled as mesoscale dynamics for the α-actinin and physical crosslink. The model has been validated with reported experimental results
Using graphic processor units for the study of electric propagation in realistic heart models
No full textAn interactive multiobjective optimization design strategy for decision based multidisciplinary design
No full textCharacterization of the mesostructure of fused‐deposition acrylonitrile‐butadiene‐styrene materials
No full textA finite element model of the embryonic zebrafish heart electrophysiology
Full text linkBackground and objective: In the last 30 years, a growing interest has involved the study of zebrafish thanks to its physiological characteristics similar to those of humans. The aim of the following work is to create an electrophysiological computational model of the zebrafish heart and lay the foundation for the development of an in-silico model of the zebrafish heart that will allow to study the correlation between pathologies and drug administration with the main electrophysiological parameters as the ECG signal.
Methods: The model considers a whole body and the two chambers of three days post fertilization (3 dpf) zebrafish. A four-variable phenomenological action potential model describes the action potential of different heart regions. Tissue conductivity was calibrated to reproduce the experimentally described activation sequence.
Results: The model is able to correctly reproduce the activation sequence and times found in literature, with activation of the atrium and ventricle that correspond to 36 and 59 ms, respectively, and a delay of 14 ms caused by the presence of the atrioventricular band (AV band). Moreover, the obtained in-silico ECG reflects the main characteristics of the zebrafish ECG in good agreement with experimental records, a P-wave with a duration of approximately the total atrial activation, followed by a QRS complex of approximately 109 ms corresponding to ventricle activation.
Conclusions: The model allows the assessment of the main electrophysiological parameters in terms of activation sequence and timing, reproducing monopolar and bipolar ECG signals in line with experimental data. Coupling the proposed model with an electrophysiological detailed action potential model of zebrafish will represent a significant breakthrough toward the development of an in-silico zebrafish heart
Analysis and improvement of a human ventricular cell model for investigation of cardiac arrhythmias
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Mechanical behavior of acrylonitrile butadiene styrene fused deposition materials modeling
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Self-expandable stent for thrombus removal modeling: Solid or beam finite elements?
Full text linkBackground: The performance of self-expandable stents is being increasingly studied by means of finite-element analysis. As for peripheral stents, transcatheter valves and stent-grafts, there are numerous computational studies for setting up a proper model, this information is missing for stent-retrievers used in the procedure of thrombus removal in cerebral arteries. It is well known that the selection of the appropriate finite-element dimensions (topology) and formulations (typology) is a fundamental step to set up accurate and reliable computational simulations. In this context, a thorough verification analysis is here proposed, aimed at investigating how the different element typologies and topologies -available to model a stent-retriever -affect simulation results.Method: Hexahedral and beam element formulations were analyzed first individually by virtually replicating a crimping test on the device, and then by replicating the thrombectomy procedure aiming at removing a thrombus from a cerebral vessel. In particular, three discretization refinements for each element type and different element formulations including both full and reduced integration were investigated and compared in terms of the resultant radial force of the stent and the stress field generated in the thrombus.Results: The sensitivity analysis on the element formulation performed with the crimping simulations allowed the identification of the optimal setting for each element family. Both setting lead to similar results in terms of stent performance in the virtual thrombectomy and should be used in future studies simulating the mechanical thrombectomy with stent-retrievers.Conclusions: The carried out virtual thrombectomy procedures confirmed that the beam element formulation results were sufficiently accurate to model the radial force and the performance of the stent-retriever during the procedure. For different self-expandable stents, hexahedral formulation could be essential in stress analysis
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