112,016 research outputs found
Swelling of the mandibular alveolar mucosa
No full textUna donna di 30 anni si presenta all’osservazione degli autori presso il Settore di Medicina Orale (Università degli Studi di Palermo) per la comparsa di una neoformazione gengivale a livello del V sestante. In anamnesi patologica remota non risultano patologie sistemiche attuali o pregresse, la paziente è in apparenti buone condizioni di salute, riferisce di non assumere farmaci e non ha subito in passato interventi chirurgici. La paziente, non fumatrice, non riferisce dolore nella sede interessata ma progressivo accrescimento della lesione.
All’esame obiettivo extra-orale non si apprezzano linfoadenopatie latero-cervicali o altre anomalie. All’esame obiettivo intra-orale si rileva una neoformazione, localizzata nel V sestante su mucosa masticatoria e alveolare tra gli elementi 4.1 e 4.3, del diametro di circa 1 cm, che si presenta di colorito roseo, rivestita da mucosa di aspetto fisiologico e integro e non mobile rispetto ai piani sottostanti. Alla palpazione è possibile apprezzare una consistenza dura-elastica. La paziente non è portatrice di protesi mobili, non sono rilevabili fattori traumatici associabili alla presenza di tale condizione; si rileva la presenza di affollamento dentario e tartaro diffuso. In considerazione della crescita della lesione e dell’aspetto clinico, si prescrive alla paziente una TC Cone-Bea
Fever with perinasal and tongue lesions: A diagnostic challenge
No full textThe diagnosis may be challenging, and high suspicion index should be maintained in immunosuppressed patients with unusual mucocutaneous lesions, even in non-endemic areas for mucocutaneous leishmaniasis
Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.
No full textMutations in the Ki-ras and TP53 genes are the most frequently observed genetic alterations in colorectal cancer (CRC). Ki-ras mutations are mostly found in codons 12 and 13, and less in codon 61. The majority of the TP53 mutations occur in the core domain which contains the sequence-specific DNA binding activity of the protein, and they results in loss of DNA binding. Few centres have sufficient patients to collect detailed information in the large numbers required to determine the impact of individual ki-ras and TP53 genotypes on outcome. Moreover, it has been reported that specific genetic alterations, and not any mutation, might play a different biological role in cancer progression. For these principal reasons, two collaborative studies have been conducted (the RASCAL and the TP53-CRC Collaborative Studies) with the aim of investigating the prognostic role of any, and specific, Ki-ras and TP53 mutations in CRC progression. The results obtained from the RASCAL studies suggest that Ki-ras mutations might have an effect on the survival rate of CRC patients, and that the specific codon 12 glycine/valine mutation might play a role in the progression of this neoplasia. The results of the TP53-CRC International Collaborative Study demonstrate the importance of primary tumor site when analyzing the prognostic value of TP53 mutations in CRC. In addition, different types of TP53 mutation might play a pivotal role in determining the biological behavior of CRC from different sites and hence the prognosis of patients. This meta-analysis produced evidence for interesting tumor site differences in the predictive value of TP53 mutation for survival benefit from 5FU chemotherapy
Self-reported autistic traits using the AQ: A comparison between individuals with ASD, psychosis, and non-clinical controls
No full textThe term “autism” was originally coined by Eugen Bleuler to describe one of the core symptoms of schizophrenia. Even if autism spectrum disorder (ASD) and schizophrenia spectrum disorders (SSD) are now considered two distinct conditions, they share some clinical features. The present study aimed to investigate self-reported autistic traits in individuals with ASD, SSD, and non-clinical controls (NCC), using the Autism-Spectrum Quotient (AQ), a 50-item questionnaire. The study was conducted in the Psychiatry Unit of Policlinico “G. Rodolico”, Catania, Italy. The AQ was administered to 35 adults with ASD, 64 with SSD, and 198 NCC. Overall, our data showed that the ASD sample scored significantly higher than NCC. However, no significant differences were detected between individuals with ASD and SSD. Notably, the three groups scored similarly in the subscale “attention to detail”. AQ showed good accuracy in differentiating ASD from NCC (AUC = 0.84), while discriminant ability was poor in the clinical sample (AUC = 0.63). Finally, AQ did not correlate with clinician-rated ADOS-2 scores in the ASD sample. Our study confirms that symptoms are partially overlapping in adults with ASD and psychosis. Moreover, they raise concerns regarding the usefulness of AQ as a screening tool in clinical populations
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Lipoma of the fossa femoralis mimicking a femoral hernia. Report of 2 cases
No full textIntroduction: Lipoma of the femoral fossa is uncommon. Often asymptomatic, femoral lipoma may growth within the circumscribed space of the femoral fossa causing pain and discomfort. A worsening pain caused by a lipomatous mass in the femoral area is a clinical feature that can mislead the diagnosis, resembling the more common condition of femoral hernia. Methods: Two cases of symptomatic lipomas of the femoral fossa mimicking an incarcerated femoral hernia are presented. In both, Caucasian female, patients clinical examination and ultrasound of the femoral region revealed a painful neoplasm suspected for incarcerated femoral hernia. Results: Intraoperatively, a mass of encapsulated fat arising from the bottom of the fossa femoralis was found. No visceral protrusion through the femoral ring could be documented. The neoplasms were removed in toto. Histology of the excised specimens evidenced the diagnosis of femoral lipomas suffering by chronic compressive damages. In a midterm postoperative follow up, both patients were symptom- free. Discusion: A correct preoperative diagnosis of femoral lipoma is challenging, even following an accurate diagnostic pathway. The cases highlighted herewith seem to confirm that lipoma of the femoral fossa can be mistaken with a femoral hernia. Conclusions: The clinical and histological features evidenced could result helpful in the differentiation of a lipomatous mass of the femoral fossa from a genuine femoral hernia
Candida spp. infections after abdominal urgent surgery: comparative analysis of histologic data for which microbiological results were positive for Candida spp.
No full textEV0515
ePoster Viewing
Diagnostic/laboratory methods other than molecular
Candida spp. infections after abdominal urgent surgery: comparative analysis of histologic data for which microbiological results were positive for Candida spp.
V. Rodolico1, G. Gulotta1, L. Montana1, G. Salamone1, D.C. Paola1
1Department of Sciences for Health Promotion and Mother Child Care, Palermo, Italy
Objectives: Microbiological identification is justified when the yeast is isolated from a sterile site, the potential clinical impact of identified
isolates from non sterile sites such as intra- abdominal organs don’t help the clinicians to determine whether the strain isolate represents
contamination, colonization, or true infection. To investigate the contribute of hystopathological investigations in surgical patients who survive
the initial postoperative period we compare histological and microbiological results positive for Candida spp. Methods: A retrospective study
of abdominal intraoperative tissue or biopsy specimens obtained from patients admitted for acute abdomen with post-operative
microbiological samples positive for Candida spp was performed for the years January 2008 to December 2012. Specimens obtained from
autopsy cases were excluded. For each case, demographic data, mortality, comorbidity conditions, antimicrobial therapy, specimen type,
the use of special histologic stains, any reported suggestion to correlate with or defer to microbiology, and the individual surgical pathologist
were recorded. Results: we evaluated 66 positive candida spp culture reports of which 56 had a concurrent surgical pathology specimen; of
the 56 cases 5 were excluded because of a known history of fungal infection, among the remaining we selected 23 (15%) histological
results because in these patients clinical, microbiological and enventual other histopathological follow-up data were available. Table 1
showed microbiological and hystopathological data. When other than blood culture specimens such as drainage were positive for candida
infection the result was suitable with histological picture. On the other hand, when the blood culture was positive the hystopathological
results (proliferative and granulomatous inflammation accompanied by numerous macrophages, lymphocytes, plasma cells and
neutrophils) were compatible with the patients’ complications to confirm that Candida spp. is a frequent opportunistic pathogen especially in
cancer disease. In table we showed comparative analysis of 23 histologic data for which microbiological results were positive for Candida
spp.
Microbiological Specimen
Positive for Candida spp (n) Concorde
Histological features Candida specie Comorbidity Outcome
(Died)
Blood 6 1 C. albicans=3C. nonalbicans=
3 Cancer=5; Cholecistitis=1 3 (c.
albican=2)
Bile 4 / C. albicans=1C. non
albicans=3
Cancer=2Chronic gastritis plus
cholecystitis =2
Drainage 6 6 C. albicans=4C. non
albicans=2 Cancer= 4Fistula=2 3 ( c.
albicans)
Biopsy 4 4 C. albicans=4C. non
albicans= Cancer=2Fistula=2 1 (c. non
albicans)
Urine 1 1 C. albicans
Bile plus blood 2 2 C. albicans
Conclusions: Post- operative Candida spp infection is an important cause of morbidity and is frequently associated with poor prognosis,
particularly in higher risk patients. Complicated intra-abdominal infections diagnosis is mainly a clinical diagnosis, therefore, low expansive
supplemental procedures for diagnosis, such as histopathology examination provide insight into the diagnostic significance of Candida spp
isolated from surgical specimens other than blood samples
Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: A rare case report and review of the literature
No full textBackground: Oral verruciform xanthoma is an uncommon benign lesion. Although oral verruciform xanthoma occurs in healthy individuals, it has been also reported in association with some inflammatory conditions. The aim of this study is to report a case of oral verruciform xanthoma associated with chronic graft-versus-host disease and to review the literature on this topic. Case presentation: A 47-year-old Caucasian male presented to the Sector of Oral Medicine "V. Margiotta", University Policlinic "P. Giaccone" of Palermo complaining of a mass on the gingiva. He first noticed the painless mass 1 year ago. He reported to have undergone allogenic hematopoietic stem cell transplantation 15 years ago for acute lymphoblastic leukaemia. Intraoral examination revealed a well-circumscribed, sessile yellowish and verrucous nodule upon canine, multiple yellowish and verrucous nodules on the hard palate, yellowish and verrucous nodules on left buccal mucosa. In addiction an area of white striae in a reticular pattern with erythema and ulceration was present on the dorsum of the tongue. This lesion was consistent with a known history of oral chronic graft versus host disease. Moreover, we observed a suspected area of oral erythroplakia yet on the dorsum of the tongue. In biopsy specimen of hard palate histopathological examination revealed a diagnosis of verrucous xanthoma of the oral cavity; in addiction in biopsy specimen of the dorsum of the tongue revealed the presence of erythroplakia with high grade dysplasia. Conclusion: Verruciform xanthoma of the oral cavity associated with chronic graft-versus-host disease is a rare condition with a usually benign clinical course but malignant transformation has been described in association with oral potential malignant disorder (e.g. chronic graft versus host disease, erythroplakia). Very rare cases showed association with oral chronic graft versus-host-disease. To date, only eight cases were published in the world literature. Therefore it could be important follow up patients also for oral verruciform xanthoma onset
Facioscapulohumeral Muscular Dystrophy and Poliomyelitis followed by Multiple Sclerosis: A “triple trouble” case report and review of the literature on the association of MS and muscle disorders
No full textWe describe herein a “triple trouble” case of a patient affected by Facioscapulohumeral Muscular Dystrophy type 1 (FSHD1), with a previous history of poliomyelitis, who later developed Multiple Sclerosis (MS). Association of muscle disorders and MS is uncommon; in fact, there are only three case reports of this unusual co-occurrence. As regard as this combination, some hypotheses have been raised about the role of immunological factors. Genetic basis of FSHD1 is a deletion of a critical number of macrosatellite repeats (D4Z4) in the subtelomeric region of chromosome 4q35, resulting in transcriptional de-repression of a gene DUX4. This molecular change could induce an alteration of immune responses, likely conferring susceptibility to both diseases. In this case, poliomyelitis could have delayed the FSHD1 diagnosis and likely acted as a trigger for MS onset. Association of multiple neurological disorders has to be kept in mind to avoid misinterpretation of symptoms and diagnostic delays
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