62 research outputs found
The Genesis of « In Memoriam Milena »
No full textLa genèse du recueil de poèmes In Memoriam Milena sera ici évoquée : circonstances et motivations, aspects prosodiques, et mise en musique par Jacques Michon.Pybus Rodney. The Genesis of « In Memoriam Milena ». In: Anglophonia/Caliban, n°11, 2002. Musique et littératures : Intertextualités. pp. 199-201
From epic journeys of freedom: runaway slaves of the American revolution and their global quest for liberty
No full textPEI: Y; PD: bibl fSource type: Electronic(1
Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
Get PDFHuman immunodeficiency virus type 1 (HIV-1) sequences that pre-date the recognition of AIDS are critical to defining the time of origin and the timescale of virus evolution. A viral sequence from 1959 (ZR59) is the oldest known HIV-1 infection. Other historically documented sequences, important calibration points to convert evolutionary distance into time, are lacking, however; ZR59 is the only one sampled before 1976. Here we report the amplification and characterization of viral sequences from a Bouin's-fixed paraffin-embedded lymph node biopsy specimen obtained in 1960 from an adult female in Léopoldville, Belgian Congo (now Kinshasa, Democratic Republic of the Congo (DRC)), and we use them to conduct the first comparative evolutionary genetic study of early pre-AIDS epidemic HIV-1 group M viruses. Phylogenetic analyses position this viral sequence (DRC60) closest to the ancestral node of subtype A (excluding A2). Relaxed molecular clock analyses incorporating DRC60 and ZR59 date the most recent common ancestor of the M group to near the beginning of the twentieth century. The sizeable genetic distance between DRC60 and ZR59 directly demonstrates that diversification of HIV-1 in west-central Africa occurred long before the recognized AIDS pandemic. The recovery of viral gene sequences from decades-old paraffin-embedded tissues opens the door to a detailed palaeovirological investigation of the evolutionary history of HIV-1 that is not accessible by other method
Portrait of Cassandra Pybus, non-fiction author [picture] /
No full textTitle from accession record.; One of a series of portraits taken at the Word Festival Canberra, 21-24 March 1997.; P1841/17
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