189,246 research outputs found
Simulations of DNA coiling around a synthetic supramolecular cylinder that binds in the DNA major groove
No full textIn this work we present the results of a molecular simulation study of the interaction between a tetracationic bis iron((II)) supramolecular cylinder, [Fe-2(C25H20N4)(3)](4+), and DNA. This supramolecular cylinder has been shown to bind in the major groove of DNA and to induce dramatic coiling of the DNA. The simulations have been designed to elucidate the interactions that lead the cylinder to target the major groove and that drive the subsequent DNA conformational changes. Three sets of multi-nanosecond simulations have been performed: one of the uncomplexed d(CCCCCTTTTTCC)d(GGAAAAAGGGGG) dodecamer; one of this DNA complexed with the cylinder molecule; and one of this DNA complexed with a neutralised version of the cylinder. Coiling of the DNA was observed in the DNA-cylinder simulations, giving insight into the molecular level nature of the supramolecular coiling observed experimentally. The cylinder charge was found not to be essential for the DNA coiling, which implies that the DNA response is moderated by the short range interactions that define the molecular shape. Cylinder charge did, however, affect the integrity of the DNA duplex, to the extent that, under some circumstances, the tetracationic cylinder induced defects in the DNA base pairing at locations adjacent to the cylinder binding site
René Descartes, Principles of Philosophy, transl. Valentine Rodger Miller and Reese P. Miller
No full textRené Descartes, Principles of Philosophy, transl. Valentine Rodger Miller and Reese P. Miller. In: Revue d'histoire des sciences, tome 37, n°3-4, 1984. p. 355
Shape effects on the activity of synthetic major-groove binding ligands
No full textIn this work we present the results of a molecular simulation study of two different tetracationic bis iron(II) supramolecular cylinders interacting with DNA. One cylinder has been shown to bind in the major groove of DNA and to induce dramatic coiling of the DNA; the second is a derivative of the first, with additional methyl groups attached so as to give a larger cylinder-radius. The simulations show that both cylinders bind strongly to the major groove of the DNA, and induce complex structural changes in A-T rich regions. Whereas the parent cylinder tends to bind along the major groove, the derivatised cylinder tends to twist so that only one end remains within the major groove. Both G-C rich and A-T rich binding sites for the derivatised cylinder are discussed. (c) 2006 Elsevier Inc. All rights reserved
George Rodger and Life Magazine Photo-Journalism
No full textThis chapter looks at the coverage of the war by the Life photojournalist George Rodger. He focused initially, as did so many other journalists, on one of the most glamorous aspects of the campaign, the role of American pilots, the American Volunteer Group (AVG), or “Flying Tigers” as they came to be known. Rodger did manage to take some action photos at one of the few successful battles, the recapture of Shwegyin. The photographic record of this battle raises important issues of the difficulties of working in tropical and jungle conditions, but also the question of whether any of the photographs involved reconstruction (faking) of events for the camera. This chapter also looks at the role of Life correspondent, Clare Boothe Luce, who, together with Rodger, photographed the meeting of General Stilwell and Chiang Kai-Shek at Maymyo.</p
Theoretical aspects of the enantiomeric resolution of dimetallo helicates with different surface topologies on cellulose columns
No full textCellulose has been used to separate the enantiomers of a range of dimetallo coordination compounds with different surface topologies. The compounds are all approximately cylindrical in shape, but are based on octahedral coordination at the metals and are also helical. When separation has been achieved, the first eluted enantiomer has always been proven to have a negative circular dichroism (CD) signal for its longest wavelength metal to ligand charge transfer band. In order to understand the underlying basis for the elution order, gas phase molecular dynamics and snap-shot minimisations of each enantiomer with the repeat unit of cellulose, glucose, have been undertaken. For new dimetallo helicates, it is important to have a quick assessment of the enantiomeric identity of the first eluted compound. To this end, the coupled-oscillator model of CD has been applied to relate the signs of the CD signals to the identity of the enantiomers. This correlation is consistent with crystallographic data for the first eluted enantiomer of the parent compound
Good practice guide 8 developing your team's educational philosophy /
No full textYour personal educational philosophy as an academic is the individual system of beliefs and values that guides your teaching practice. Even if you are not aware that you have an educational philosophy this underlying system is what you use to guide your decision making in your design of teaching and learning activities, your attitudes towards students and how they learn, and your engagement withteaching technologies. It also helps you define and enact your role as an educator within your profession, your organization and your broader societal contexts
Numerical simulation of the critical ionization velocity mechanism
No full textThesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1992.Includes bibliographical references (p. 251-257).by Rodger J. Biasca.Sc.D
Contents: Speaker Presentations & Workshop Overview
No full textSpeaker Presentations
Welcome/Introductions (Rodger Holdsworth)
Opening Remarks (Chris Oynes)
Opening Remarks (Ken Arnold)
Opening Remarks (Tom Theriot)
Integration of Human Factors into Classification/Certification (James Card)
Overview of the P-36 Incident (Carlos TadeuDa Costa Frage)
P 36_Movie.avi (Pedro Jose Barusco Filho)
Workshop Overview Powerpoint
1996 Workshop Purpose
What We Learned
HFW2002 Workshop Purpose
Workshop Objectives
Most Common Questions and Answers
Questions
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