205 research outputs found
Orbit design for future SpaceChip swarm missions in a planetary atmosphere
No full textThe effect of solar radiation pressure and atmospheric drag on the orbital dynamics of satellites-on-a-chip (SpaceChips) is exploited to design equatorial long-lived orbits about the oblate Earth. The orbit energy gain due to asymmetric solar radiation pressure, considering the Earth's shadow, is used to balance the energy loss due to atmospheric drag. Future missions for a swarm of SpaceChips are proposed, where a number of small devices are released from a conventional spacecraft to perform spatially distributed measurements of the conditions in the ionosphere and exosphere. It is shown that the orbit lifetime can be extended and indeed selected through solar radiation pressure and the end-of-life re-entry of the swarm can be ensured, by exploiting atmospheric drag
2010 Presidential address: Culture: The silent language geneticists must learn - Genetic research with indigenous populations
No full textChallenges and opportunities for future Canadian physician-scientists: Perspectives of four experts
No full textIn this series of interviews, the Clinical and Investigative Medicine editorial team gathered expert opinions on the future of physician-scientist training and career prospects in Canada. This was inspired by recent publications that voiced concerns over the diminishing support for the physician-scientist in Canada and the United States. For this editorial, the term physician-scientist was intentionally broad and inclusive; referring to individuals who identify both clinical work and biomedical or healthcare research as major components of their career. The following leaders in medical research or research funding shared their perspectives: Roderick R. McInnes; Michel G. Bergeron; Thomas J. Marrie; and Bev J. Holmes
Causation in tort law: Back to basics at the Supreme Court of Canada
Get PDFThis article analyzes the role of causation in Canadian tort law. The author uses the recent Supreme Court of Canada decision of Athey v. Leonati as a model to show how even complex problems of causation can be solved through the application of fundamental principles of tort law: the \"restoration\" principle, the \"take your victim\" principle, and the \"vicissitudes\" principle. The author also demonstrates the importance of distinguishing types of causes based on the following dichotomies: tortious and non-tortious, sufficient and insufficient, and simultaneous and successive. The author argues that applying these principles, and distinguishing causes in this manner, will greatly simplify the resolution of even seemingly complex problems of causation in tort law. | L 'auteur analyse le rdle de la causalitd dans les r~gles de droit applicables aux prijudices au Canada. 11 utilise la d&cision ricente de la Cour supreme du Canada dans Athey c. Leonati pour montrer comment risoudre des problmes de causalitd complexes 6t l'aide de certains principes fondamentaux : le principe de rdtablissement [i Ia situation originale], le principe de Ia vulndrabiliti de la victime et le principe des vicissitudes. L 'auteur dmontre qu 'il est important de distinguer les cas d 'apr~s les dichotomies suivantes : prijudiciable et non prdjudiciable, suffisant et insuffisant, simultang et successif II soutient que l'application de ces principes et de ces distinctions simplifie considirablement la risolution de probldmes de causalitd qui semblent pourtant tris complexes dans ce domaine du droit
A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo
Get PDFIn vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses. Until now, invasive surgery has been required for microscopic access to lymph nodes (LNs), making repeated imaging of the same animal impractical and potentially affecting lymphocyte behavior. To allow longitudinal in vivo imaging, we conceived the novel approach of transplanting LNs into
the mouse ear pinna. Transplanted LNs maintain the structural and cellular organization of conventional secondary lymphoid organs. They participate in lymphocyte
recirculation and exhibit the capacity to receive and respond to local antigenic challenge. The same LN could be repeatedly imaged through time without the requirement for surgical exposure, and the dynamic behavior of the cells within the transplanted LN could be characterized. Crucially, the use of blood vessels as fiducial markers also allowed precise re-registration of the same regions for
longitudinal imaging. Thus, we provide the first demonstration of a method for repeated, noninvasive, in vivo imaging of lymphocyte behavior
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