1,720,967 research outputs found
Effects of rotational stress on the effectiveness of razoxane and cyclophosphamide in mice bearing Lewis lung carcinoma
No full textBloccanti adrenergici, stress psicologico e disseminazione metastatica in topi portatori del Lewis lung carcinoma
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Disorientamento spaziale, disseminazione metastatica, e funzioni immunitarie in topi portatori di Lewis lung carcinoma
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Psychosocial factors and breast cancer: A 6-year Italian follow-up study
No full textBackground. Over the last 20 years contradictory results were obtained as regards to the role of psychosocial factors in favouring the onset of breast cancer and/or in influencing disease progression. Methods. The present study prospectively investigated the association between psychosocial variables and breast cancer in ninety-five out-patients. Within three months from the diagnosis the patients completed a series of questionnaires to evaluate psychological disturbances, emotional repression, adjustment to cancer, social support and occurrence of life events in the previous five years. At a distance of six years from the first assessment, the patients’ charts were re-analyzed in order to evaluate the course of cancer. Results. A higher volume of primary tumour at surgery was shown in patients who had had stressful events in the six months preceding cancer diagnosis. At follow-up, no relationship was found between psychosocial variables and the course of disease. The analysis of the frequency of relapses and deaths, and the survival analysis indicated that positivity of loco-regional lymph nodes, infiltrating histotype of the tumor and tumour stage were the only significant predictors of the time of death. Conclusions. The study suggests that clinical and biological, rather than psychsocial factors exert a major role in breast cancer progression
Metastasis and neuroendocrine system in stressed mice
No full textThe effects of experimental stressors have been examined for their differential effects on primary tumor growth and spontaneous lung metastasis in syngeneic mice bearing the weakly immunogenic tumor Lewis lung carcinoma. The effects caused by the early weaning, physical restraint and foot-shock are in general small, and affected by a high variability. On the contrary, spatial disorientation reproducibly causes a specific increase in tumor metastases. The effects of spatial disorientation are sensitive to the inhibition by treatment with bromocryptine and guanethidine, and particularly by a central and peripheral adrenergic neuron blocking agent reserpine. The use of different lighting conditions and assay of urinary melatonin excretion reveal an association between pineal gland function and effects of spatial disorientation on metastasis
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