234 research outputs found
STUDY OF ORAL CAVITY LESIONS BY INFRARED SPECTROSCOPY
No full textFourier transform infrared (FTIR) microspectroscopy is considered a useful tool in the biomedical field, for analysing in situ and at cellular level, very small areas of tissues and cells, with minimal sample preparation and without the use of stains or probes. This spectroscopic technique has been successfully applied to analyse biological samples from patients affected by tumoral pathologies, with particular attention to oral cavity lesions. In this study, we describe the application of FTIR microspectroscopy to characterize and discriminate the most recurrent benign and malignant diseases of oral cavity compartment. Infrared maps were acquired on tissues affected by the following pathologies: squamous cell carcinoma, adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, squamous dysplasia, keratocystic odontogenic tumor, radicular cyst, residual cyst, unicystic ameloblastoma, and ameloblastic fibroma, together with healthy tissue samples (used as control group). The epithelial and connective components of all samples were distinguished and submitted to multivariate analysis. The results were in agreement with histological suggestions
Expression and prognostic significance of apoptotic genes in oral squamous cell carcinoma
No full textEducación Jurídica Internacional
No full text"Originally published as International Legal Education, in 26 Harv. Int'l L. J. 361 (1985). Translation by Public Translator Romina Redondo. The editors gratefully acknowledge the generosity of the author and the authorities of the Harvard International Law Journal in allowing the translation and reproduction of the article."Fil: Kennedy, David. Harvard University. Law School. Institute for Global Law and Policy. Cambridge, Estados Unidos"Publicado originalmente como International Legal Education, en 26 Harv. Int'l L. J. 361 (1985). Traducción a cargo de la Trad. Públ. Romina Redondo. Los editores agradecen la generosidad del autor y de las autoridades del Harvard International Law Journal al permitir la traducción y reproducción del artículo"
VIBRATIONAL MAPPING OF SINONASAL LESIONS BY FOURIER TRANSFORM INFRARED IMAGING SPECTROSCOPY
No full textFourier transform infrared imaging (FTIRI) is a powerful tool for analyzing biochemical changes in
tumoral tissues. The head and neck region is characterized by a great variety of lesions, with different degrees
of malignancy, which are often difficult to diagnose. Schneiderian papillomas are sinonasal benign neoplasms
arising from the Schneiderian mucosa; they can evolve into malignant tumoral lesions (squamous cell carcinoma).
In addition, they can sometimes be confused with the more common inflammatory polyps. Therefore,
an early and definitive diagnosis of this pathology is mandatory. Progressing in our research on the study of oral
cavity lesions, 15 sections consisting of inflammatory sinonasal polyps, benign Schneiderian papillomas, and
sinonasal undifferentiated carcinomas were analyzed using FTIRI. To allow a rigorous description of these pathologies
and to gain objective diagnosis, the epithelial layer and the adjacent connective tissue of each section
were separately investigated by following a multivariate analysis approach. According to the nature of the lesion,
interesting modifications were detected in the average spectra of the different tissue components, above all in
the lipid and protein patterns. Specific band-area ratios acting as spectral markers of the different pathologies
were also highlighted. © 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JBO.20.12.125003
Periodontal status in the Down’s syndrome subjects living in central-eastern Italy: the effects of place of living
No full textAim: The purpose of this study was to determine the influence of the place of living on periodontal status of 62 Down’s syndrome (DS) subjects resident at home (DSH) or in specialized institutes (DSI) in central-eastern Italy. Methods: The demographic characteristics of the subjects and the periodontal variables were evaluated according to their living conditions. Descriptive analyses were conducted by stratifying subjects into three age groups (0-13; 14-22; >23 years), using medians and 25th - 75th percentiles to summarized data. Comparisons between DSH and DSI subjects were performed using Wilcoxon rank sum test. The effect of demographic and clinical variables on periodontal status was evaluated by means of quantile regression analysis. Results: No significant differences resulted between DSH and DSI patients, when compared for gender, age and mental retardation. No significant differences were found in the periodontal variables for the subjects with 0-13 years, while DSI subjects between 14-22 years of age presented higher levels of Plaque Index, Probing Depth, Clinical Attachment Loss and a lower number of surviving teeth compared to DSH subjects. When DSI and DSH groups ≥23 years of age were compared no differences were observed in the periodontal conditions except for PI and the number of surviving teeth. Age, body mass index, and severe mental retardation were found to be significant predictors of periodontal conditions. Conclusions: Institutionalization has a negative effect on surviving teeth number of Down’s syndrome subjects. Furthermore, the home care seems to produce benefits on the periodontal conditions of DSH 14-22 years of age
Pathways of Peace. The Philosophy and Sociology of Peace and Nonviolence.
No full textThis book explores the close interconnection that exists between sociological and philosophical scholarship in relation to peace studies. Through an examination of the thought of nine leading philosophers and sociologists in their historical and geographical context, the author considers notions of nonviolent resistance, pacifism and reverse strike, as well as violence theories of conflict, theories of conflict resolution, the problem of war, and political transitions towards democratization. Engaging with the work of Thoreau, Gandhi, Ghaffar Khan, Capitini, Dolci, Bobbio, Galtung, Sharp and Weil, and considering the institutionalisation of peace research, this volume will appeal to scholars and students of sociology, politics and philosophy with interest in peace and security studies, and conflict
Pokemon proto-oncogene in oral cancer: potential role in the early phase of tumorigenesis
No full textOral squamous cell carcinoma (OSCC) represents about 90% of all oral neoplasms with a poor clinical prognosis. To improve survival of OSCC patients, it is fundamental to understand the basic molecular mechanisms characterizing oral carcinogenesis. Dysregulation of oncogenes and tumor suppressor genes seems to play a central role in tumorigenesis, including malignant transformation of the oral cavity
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