359 research outputs found
sj-docx-1-asm-10.1177_10731911231195844 – Supplemental material for Validation of Self-Administered Visual and Verbal Episodic Memory Tasks in Healthy Controls and a Clinical Sample
No full textSupplemental material, sj-docx-1-asm-10.1177_10731911231195844 for Validation of Self-Administered Visual and Verbal Episodic Memory Tasks in Healthy Controls and a Clinical Sample by Darlene P. Floden, Olivia Hogue, Abagail F. Postle and Robyn M. Busch in Assessment</p
sj-docx-2-msj-10.1177_13524585221127941 – Supplemental material for A proposed new taxonomy of cognitive phenotypes in multiple sclerosis: The International Classification of Cognitive Disorders in MS (IC-CoDiMS)
No full textSupplemental material, sj-docx-2-msj-10.1177_13524585221127941 for A proposed new taxonomy of cognitive phenotypes in multiple sclerosis: The International Classification of Cognitive Disorders in MS (IC-CoDiMS) by Laura M Hancock, Rachel Galioto, Alexey Samsonov, Robyn M Busch, Bruce Hermann and Jordi A Matias-Guiu in Multiple Sclerosis Journal</p
sj-docx-1-msj-10.1177_13524585221127941 – Supplemental material for A proposed new taxonomy of cognitive phenotypes in multiple sclerosis: The International Classification of Cognitive Disorders in MS (IC-CoDiMS)
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585221127941 for A proposed new taxonomy of cognitive phenotypes in multiple sclerosis: The International Classification of Cognitive Disorders in MS (IC-CoDiMS) by Laura M Hancock, Rachel Galioto, Alexey Samsonov, Robyn M Busch, Bruce Hermann and Jordi A Matias-Guiu in Multiple Sclerosis Journal</p
Speculu[m] exemploru[m] ex diuersis libris in vnu[m] laboriose collectu[m].
No full textEerste blad (blanco) ontbreektThe author is probably Johannes Busch (CIBN)Titel uit incipit. Drukker en datum uit colofonBMC: Catalogue of books printed in the XVth century now in the British Museum I 226bGesamtkatalog der Wiegendrucke ; M42951Machiels, J. Catalogus van de boeken gedrukt vóór 1600 ; S 488Polain, M.-L. Catalogue des livres imprimé au 15e siècle ... ; 3574Europeana-GoogleBook
A taxonomic approach to cognitive diagnostics is viable and achievable in MS
No full text20.500.12530/8785
A proposed new taxonomy of cognitive phenotypes in multiple sclerosis: The International Classification of Cognitive Disorders in MS (IC-CoDiMS)
No full text20.500.12530/87855Background:Characterization of cognitive impairment (CI) in multiple sclerosis into distinct phenotypes holds promise for individualized treatments and biomarker exploration. Objective:Apply a previously validated, neuropsychologically driven diagnostic algorithm to identify a taxonomy of the type of cognitive phenotypes in multiple sclerosis. Methods:An algorithm developed and validated in other neurological diseases was applied to a cohort of 1281 people with multiple sclerosis who underwent clinical neuropsychological evaluation across three multiple sclerosis centers. A domain was marked impaired if scores on two tests within the domain fell below one of the two thresholds of interest (compared to controls; -1.0 SD and -1.5 SD below the mean). Results were then tabulated for each participant to determine the type of impairments across the sample. Results:At -1 SD threshold, 48.7% were intact, 21.6% had single-domain, 14.3% bi-domain, and 15.4% multi-domain impairment. At -1.5 SD threshold, 72.9% were intact, 14.0% had single-domain, 8.2% bi-domain, and 5.0% multi-domain impairment. Processing speed was the most frequent single-domain impairment, followed by executive function and memory. Conclusions:These findings advance the taxonomy of cognitive phenotypes in multiple sclerosis and clarify the type and distribution of possible cognitive diagnoses, pave the way for further investigation of associated biomarkers, and provide clinically meaningful information to guide individualized treatment and rehabilitation
Blood lead levels increase, but remain in normal range with severe weight reduction.
No full textHigh bone turnover states are known to raise blood lead levels (BPb). Caloric restriction will increase bone turnover, yet it remains unknown if weight reduction increases BPb due to mobilization of skeletal stores. We measured whole blood Pb levels (²⁰⁶Pb) by inductively coupled plasma mass spectrometry in 73 women (age 24–75 years; BMI 23– 61 kg/m²) before and after 6 months of severe weight loss (S-WL), moderate weight loss (M-WL), or weight maintenance (WM). Baseline BPb levels were relatively low at 0.2–6.0 μg/dl, and directly associated with age (r=0.49, P<0.0001). After severe WL (-37.4±9.3 kg, n=17), BPb increased by 2.1±3.9 μg/dl (P<0.05), resulting in BPb levels of 1.3–12.5 μg/dl. M-WL (-5.6±2.7 kg, n=39) and WM (0.3±1.3 kg, n=17) did not result in an increase in BPb levels (0.5±3.2 and 0.0±0.7 μg/dl, M-WL and WM, respectively). BPb levels increased more with greater WL (r=0.24, P<0.05). Bone turnover markers increased only with severe WL and were directly correlated with WL. At baseline, higher calcium intake was associated with lower BPb (r=-0.273, P<0.02), however, this association was no longer present after 6 months. Severe weight reduction in obese women increases skeletal bone mobilization and BPb, but values remain well below levels defined as Pb overexposure.This research was supported by the NIEHS sponsored UMDNJ Center for Environmental Exposures and Disease, Grant number: NIEHS P30ES005022, in part by NIH-AG12161, and a Busch Biomedical Award to SA Shapses.National Institutes of Health: AG12161, to S.A. ShapsesCharles & Johanna Busch Biomedical Grant, to S.A. ShapsesThe published version of this paper is available at: http://www.nature.com/je
Asymptotic Behavior of Strategies in the Repeated Prisoner's Dilemma Game in the Presence of Errors
No full textWe examine the asymptotic behavior of a finite, but error-prone population, whose agents can choose one of ALLD (always defect), ALLC (always cooperate), or Pavlov (repeats the previous action if the opponent cooperated and changes action otherwise) to play the repeated Prisoner's Dilemma. A novelty of the study is that it allows for three types of errors that affect agents' strategies in distinct ways: (a) implementation errors, (b) perception errors of one's own action, and (c) perception errors of the opponent's action. We also derive numerical results based on the payoff matrix used in the tournaments of Axelrod (1984). Strategies' payoffs are monitored as the likelihood of committing errors increases from zero to one, which enables us to provide a taxonomy of best response strategies. We find that for some range of error levels, a unique best response (i.e. a dominant strategy) exists. In all other, the population composition can vary based on the proportion of each strategist's type and/or the payoffs of the matrix. Overall, our results indicate that the emergence of cooperation is considerably weak at most error levels
Personalized design process for persuasive technologies
No full textIn this position paper we discuss the application of personalization in persuasive technology design in light of the Personalized Design Process model (PDP-model). The PDP-model defines personalization as aligning a persuasive product to the end-user by stakeholder involvement (i.e. designers, endusers, domain experts and family/relatives) across the Problem Definition-, the Product Design- and/or the Tailoring design phases. It is expected that personalization in a PDP enhances the motivation of end-users to interact longer and more frequently with a product, increasing the likelihood that the product will reach its aimed-for effect. Although personalization in a PDP is a common method in persuasive product design, its added value has not been sufficiently validated by scientific research. We propose several reasons for the frequent use of personalization in a PDP, despite the lack of evidence for its added value. Furthermore, we discuss how personalization could be validated according to the PDP-model.Design Aesthetic
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