3,607 research outputs found
Analysis of Caesarean Section Rates and Source of Payment Using the Robson Classification System
No full textBackground: Sectio caesarea delivery is the last alternative to save the mother and fetus when normal delivery is not possible. The increase in caesarean section worldwide has become a major public health problem, so it is necessary to supervise to reduce the number of caesarean sections that are considered unnecessary, one of which is through the Robson Classification. The existence of health insurance for the people of Indonesia, including BPJS which covers the costs of sectio caesarea, makes it possible to increase the incidence of sectio caesarea. The aim of the study was to analyze the incidence of sectio caesarea and financing status based on Robson's classification at Muhammadiyah Babat Hospital.Subjects and Method: This study used a retrospective observational analytic method with a cross sectional design. The research sample was mothers giving birth at Muhammadiyah Babat Hospital who were included in the inclusion criteria and were taken through a total sampling technique of 127 mothers giving birth. The dependent variable is sectio caesarea. The independent variable is financing status. The instrument used was medical record data collected in collection sheets and analyzed using the Chi Square test. Results: A total of 87 (68.5%) subjects gave birth by sectio caesarea with the prevalence of the Robson group 2, 4, and 5 as the main contributor. A total of 64 (63.4%) subjects gave birth by sectio caesarea with BPJS financing status. The results of the chi-square analysis showed that mothers with BPJS financing status reduced the incidence of sectio caesarea, and it was statistically significant (OR= 0.23; 95% CI= 0.06 to 0.80; p= 0.026).Conclusion: The data shows that the incidence of sectio caesarea is still very high and most are in the Robson group 1-5 with BPJS financing status. Based on Robson's grouping results, there is a relationship between financing status and the incidence of sectio caesarea, BPJS financing status reduces the incidence of caesarean section.Keywords: sectio caesarea, robson classification, financing status.Correspondence: Budi Prasetyo, Department of Obstetrics and Gynecology, Facullty of Medicine, Universitas Airlangga, Indonesia, Jl. Mayjen Pro. Dr. Moestopo No. 47, Pacar Kembang, Kec. Tambaksari, Kota SBY, Jawa Timur 60132 Indonesia. Email: [email protected]. Mobile: +6281553019486.Journal of Maternal and Child Health (2023), 08(01): 1-11https://doi.org/10.26911/thejmch.2023.08.01.01
Reflections of a Jewish, Lesbian Author
No full textIn this essay, Jewish lesbian author Leslea Newman speaks of the importance of finding one's own identity reflected in works of literature, citing examples of her own work, and recommending the writings of other Jewish lesbian authors of merit
Embodiment in 3D virtual retail environments: exploring perceptions of the virtual shopping experience
No full textThe customer can now easily create, and customize, their own personal three dimensional (3D) virtual bodies in a variety of virtual environments; could you, by becoming a virtual body, actually enhance your online shopping and buying experiences or, would this potentially inhibit the pure visceral pleasure of retail therapy?
"Second Life allows you to be a celebrity in your own lunchtime, .…you can design the body you've always wanted, and indulge your fashionista fetish for very little money. You can be the most attractive, best-dressed version of yourself you can imagine."
This paper investigates online shopping in Second Life, through the experience of being avatars.
We will discuss the possibilities of using avatars as brand new consumer identities for personalised and customised fashion shopping within the 3D multi user virtual environment, and question the influences and effects of these developments on the traditional high street shopping trip.
The hyper un-realistic and non-sensory interface of online shopping for clothes has been hotly debated over the last decade; through the media, the industry and most importantly by the buying public. The customer’s inability to try on and experience the product has been the main inhibitor to shopping on-line, and the high levels of product returns in home shopping dramatically reflect this reality. Faster broadband connections and improved 2D web sites are making clothes shopping on the web more accessible, and for important customer groups, such as young professional females, and plus-size teenagers, virtual 3D technologies offer freedom of choice in any location.
Retailers are now confidently providing different shopping experiences by combining 2D and 3D interactive visualisation technologies with advanced marketing techniques, to create virtual retail environments that attempt to actualise the true essence of shopping; by browsing, socialising, trying-on before buying and, in a new twist, leaving the store proudly wearing the item just purchased. American Apparel, Bershka, L’Oreal, Calvin Klein, Reebok, Sears, Nike and Adidas are pioneering virtual mega stores, and all offer newly innovative, and alternative shopping experiences inside 3D multi user virtual environments.
An experiential and exploratory approach will be used to investigate fashion brands, and their virtual 3D stores in Second Life. As 3D avatars, we will record a range of customer perceptions and attempt to map their shopping patterns in this massively popular virtual world. The qualitative data gathered will inform discussions about the value of the virtual shopping experience for the customer and the retailer. Conclusions will also question the possibility of using avatars in a virtual shopping environment to acquire accurate body specifications for better fit and the collection of personal details for use in the future development of alternative shopping experiences
Safety of obinutuzumab alone or combined with chemotherapy for previously untreated or relapsed/refractory chronic lymphocytic leukemia in the Phase 3b GREEN study
No full textThe safety of obinutuzumab, alone or with chemotherapy, was studied in a non-randomized, open-label, non-comparative, Phase 3b study (GREEN) in previously untreated or relapsed/refractory chronic lymphocytic leukemia. Patients received obinutuzumab 1000 mg, alone or with chemotherapy (investigator's choice of fludarabine-cyclophosphamide for fit patients, chlorambucil for unfit patients or bendamustine for any patient), on day 1, 8 and 15 of cycle 1, and day 1 of cycles 2-6 (28-day cycles), with the cycle 1/day 1 dose administered over 2 days. The primary endpoint was safety/tolerability. Between October 2013 and March 2016, 972 patients were enrolled and 971 treated (126 with obinutuzumab monotherapy, 193 with obinutuzumab-fludarabine-cyclophosphamide, 114 with obinutuzumab-chlorambucil and 538 with obinutuzumab-bendamustine). Grade ≥3 adverse events occurred in 80.3% of patients, and included neutropenia (49.9%), thrombocytopenia (16.4%), anemia (9.6%) and pneumonia (9.0%); rates were similar in first-line and relapsed/refractory patients, and in first-line fit and unfit patients. Using expanded definitions, infusion-related reactions were observed in 65.4% of patients (grade ≥3, 19.9%; mainly seen during the first obinutuzumab infusion), tumor lysis syndrome in 6.4% (clinical and laboratory; highest incidence with obinutuzumab-bendamustine [9.3%]) and infections in 53.7% (grade ≥3, 20.1%). Serious and fatal adverse events were seen in 53.1% and 7.3% of patients, respectively. In first-line patients, overall response rates at 3 months post-treatment exceeded 80% for all obinutuzumab-chemotherapy combinations. In the largest trial of obinutuzumab to date, toxicities were generally manageable in this broad patient population. Safety data were consistent with previous reports, and response rates were high. Clinicaltrials.gov identifier: NCT01905943
Deciphering c-MYC-regulated genes in two distinct tissues
No full textBackground: The transcription factor MYC is a critical regulator of diverse cellular processes, including both
replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes
in vivo remain obscure. To address this we have examined time-dependent changes in global gene expression in
two transgenic mouse models in which MYC activation, in either skin suprabasal keratinocytes or pancreatic islet bcells,
promotes tissue expansion or involution, respectively.
Results: Consistent with observed phenotypes, expression of cell cycle genes is increased in both models (albeit
enriched in b-cells), as are those involved in cell growth and metabolism, while expression of genes involved in
cell differentiation is down-regulated. However, in b-cells, which unlike suprabasal keratinocytes undergo
prominent apoptosis from 24 hours, there is up-regulation of genes associated with DNA-damage response and
intrinsic apoptotic pathways, including Atr, Arf, Bax and Cycs. In striking contrast, this is not the case for suprabasal
keratinocytes, where pro-apoptotic genes such as Noxa are down-regulated and key anti-apoptotic pathways (such
as Igf1-Akt) and those promoting angiogenesis are up-regulated. Moreover, dramatic up-regulation of steroid
hormone-regulated Kallikrein serine protease family members in suprabasal keratinocytes alone could further
enhance local Igf1 actions, such as through proteolysis of Igf1 binding proteins.
Conclusions: Activation of MYC causes cell growth, loss of differentiation and cell cycle entry in both b-cells and
suprabasal keratinocytes in vivo. Apoptosis, which is confined to b-cells, may involve a combination of a DNAdamage
response and downstream activation of pro-apoptotic signalling pathways, including Cdc2a and p19Arf/
p53, and downstream targets. Conversely, avoidance of apoptosis in suprabasal keratinocytes may result primarily
from the activation of key anti-apoptotic signalling pathways, particularly Igf1-Akt, and induction of an angiogenic
response, though intrinsic resistance to induction of p19Arf by MYC in suprabasal keratinocytes may contribute
Staging the life-world: Habermas and the recuperation of Austin speech act theory
No full textPT: J; CR: APEL KO, 1976, SPRACHPRAGMATIK PHIL AUSTIN JL, 1962, HOW TO DO THINGS WOR AUSTIN JL, 1970, PHILOS PAPERS CULLER J, 1982, DECONSTRUCTION DERRIDA J, 1977, GLYPH, V1 ECO U, 1992, UNDERSTANDING ORIGIN, P273 FISH S, 1987, TRACING LIT THEORY HABERMAS J, 1984, THEORY COMMUNICATIVE, V1 HABERMAS J, 1987, THEORY COMMUNICATIVE, V2 HABERMAS J, 1989, JURGEN HABERMAS SOC MARTINET A, 1962, FUNCTIONAL VIEW LANG, P24 QUINE WV, 1960, WORD OBJECT SEARLE JR, 1969, SPEECH ACTS SEARLE JR, 1977, GLYPH, V1 VANEEMEREN F, 1983, SPEECH ACTS ARGUMENT WARNOCK GJ, 1989, FL AUSTIN; NR: 16; TC: 0; J9: J THEOR SOC BEHAV; PG: 12; GA: KR147Source type: Electronic(1
MODEIN2 and Colby: computer codes for sediment transport computations
No full textNovember, 1976.CER76-77VMP-JL-DBS19
Dormancy in stored malting barley: Quantifying the rate of break and the effect of cooling
No full textThe rate of break of dormancy of the varieties Plaisant, Fanfare, Pearl, Halcyon and Chariot, was examined at storage temperatures of 8, 16, 25 and 33\ub0C. The data was fitted using a probit model and the results were compared with those for three previously tested varieties, Triumph, Blenheim and Pipkin. Three varieties - Plaisant, Fanfare and Pearl - were found to emerge from dormancy more slowly than the slowest previously-tested variety, Triumph, suggesting that breeding programs are not assigning a high priority to the issue of dormancy-break-rate. Data provided by Cochrane was also fitted, quantifying the rate of break for a further three varieties. To make the results more accessible to maltsters and store managers, a three-level banding scheme has been proposed. A second experiment examined whether sudden cooling could induce \u27secondary dormancy\u27. Samples of Fanfare and Plaisant were stored at 12% and 15% moisture content, and dormancy was broken at 33\ub0C and 25\ub0C. Samples were transferred to 8\ub0C at different times. Cooling did not result in a drop in Germinative Energy. Evidence of \u27secondary dormancy\u27 was not observed
Tunneling microscopy of NbSe2 in air
No full textPT: J; CR: BANDO H, 1987, JPN J APPL PHYS PT 2, V26, L41 BINNIG G, 1982, PHYS REV LETT, V49, P57 BRYANT A, 1986, APPL PHYS LETT, V48, P832 FELDMAN JL, 1976, J PHYS CHEM SOLIDS, V37, P1141 FELDMAN JL, 1981, J PHYS CHEM SOLIDS, V42, P1029 JERICHO MH, 1980, PHYS REV B, V22, P4907 JERICHO MH, 1987, REV SCI INSTRUM, V58, P1349 MAMIN HJ, 1986, PHYS REV B, V34, P9015 PETHICA JB, 1986, IBM J RES DEV, V30, P455 RAO GVS, 1979, PHYSICS CHEM MATERIA, P99 SOLER JM, 1986, PHYS REV LETT, V57, P444 TERSOFF J, 1986, PHYS REV LETT, V57, P440 TOKUMOTO H, 1986, JPN J APPL PHYS, V25, L621; NR: 13; TC: 14; J9: J APPL PHYS; PG: 4; GA: L5219Source type: Electronic(1
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
No full textBackground: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic fatigue syndrome patients from two UK cohorts and 395 controls for evidence of XMRV infection by looking either for the presence of viral nucleic acids using quantitative PCR (limit of detection <16 viral copies) or for the presence of serological responses using a virus neutralisation assay.
Results: We have not identified XMRV DNA in any samples by PCR (0/299). Some serum samples showed XMRV neutralising activity (26/565) but only one of these positive sera came from a CFS patient. Most of the positive sera were also able to neutralise MLV particles pseudotyped with envelope proteins from other viruses, including vesicular stomatitis virus, indicating significant cross-reactivity in serological responses. Four positive samples were specific for XMRV.
Conclusions: No association between XMRV infection and CFS was observed in the samples tested, either by PCR or serological methodologies. The non-specific neutralisation observed in multiple serum samples suggests that it is unlikely that these responses were elicited by XMRV and highlights the danger of over-estimating XMRV frequency based on serological assays. In spite of this, we believe that the detection of neutralising activity that did not inhibit VSV-G pseudotyped MLV in at least four human serum samples indicates that XMRV infection may occur in the general population, although with currently uncertain outcomes
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